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Thyroid Hormone Synthesis, Plasma Membrane Transport and Metabolism

  • Chapter
Pharmacotherapeutics of the Thyroid Gland

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 128))

Abstract

The most important iodothyronine secreted by the thyroid gland is 3,5,3’,5’-tetraiodothyronine (thyroxine, T4). Thyroxine has little, if any, biological activity, and is converted to the active hormone par excellence, i.e. 3,5,3’-triiodothyronine (T3). In man about 80% of total plasma T3 production is extrathyroidally converted to T3 (see below), while 20% is secreted by the thyroid gland.

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Authors
  1. G. Hennemann
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  2. T. J. Visser
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Editors and Affiliations

  1. Department of Medicine Clinical Sciences Centre Northern General Hospital, The University of Sheffield, Sheffield, S5 7AU, UK

    A. P. Weetman (Professor of Medicine) (Professor of Medicine)

  2. Department of Endocrinology, St. Bartholomew’s Hospital, West Smithfield, London, EC1A 7BE, UK

    A. Grossman

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Hennemann, G., Visser, T.J. (1997). Thyroid Hormone Synthesis, Plasma Membrane Transport and Metabolism. In: Weetman, A.P., Grossman, A. (eds) Pharmacotherapeutics of the Thyroid Gland. Handbook of Experimental Pharmacology, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60709-7_4

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