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Proteins Implicated in Neurotransmitter Release and Reuptake

  • Heinrich Betz
  • Vincent O’Connor
  • Thomas Dresbach
  • Lorenzo Pellegrini
  • Kurt Bommert
  • William DeBello
  • James M. Hunt
  • Felix Schweizer
  • George Augustine
  • Milton P. Charlton
  • Ralph Adams
  • Kohji Sato
  • Andreas W. Püschel
  • Cyrille Sur
  • Patrick Schloss
Conference paper
Part of the NATO ASI Series book series (volume 100)

Abstract

Neurotransmitter release and reuptake are essentiell steps in the life-cycle of neurotransmitters at the synapse. Biochemical evidence indicates that the exocytotic release process involves both evolutionarily conserved membrane proteins, the SNAREs, as well as ubiquitous cytosolic fusion proteins, NSF and SNAPs. We have tested the physiological role of both SNAREs and SNAPs at the squid giant synapse. Our data are consistent with both SNAPs and SNAREs having post-docking functions in neurotransmitter exocytosis. Analysis of the gene structure. developmental expression and pharmacology of the glycine transporter GlyT1 and the serotonin transporter SERT1 indicates a high diversity and complex regulation of mammalian neurotransmitter uptake systems.

Keywords

Botulinum Toxin Synaptic Vesicle Neurotransmitter Release Snare Complex Tetanus Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Heinrich Betz
    • 1
  • Vincent O’Connor
    • 1
  • Thomas Dresbach
    • 1
  • Lorenzo Pellegrini
    • 1
  • Kurt Bommert
    • 1
  • William DeBello
    • 2
  • James M. Hunt
    • 2
  • Felix Schweizer
    • 2
  • George Augustine
    • 2
  • Milton P. Charlton
    • 3
  • Ralph Adams
    • 1
  • Kohji Sato
    • 1
  • Andreas W. Püschel
    • 1
  • Cyrille Sur
    • 1
  • Patrick Schloss
    • 1
  1. 1.Abteilung NeurochemieMax-Planck-Institut für HirnforschungFrankfurtGermany
  2. 2.Department of NeurobiologyDuke University Medical CenterDurhamUSA
  3. 3.Department of PhysiologyUniversity of TorontoOntarioCanada

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