Skip to main content

Tissue Oxygenation

  • Chapter
  • 222 Accesses

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 28))

Abstract

The supply of oxygen to the cells is the most essential function developed in aerobic organisms, since its shortage is unavoidably associated with the failure of the cellular functions and, eventually, with the death of the entire organism. The goal of providing this essential stuff is accomplished via a complex interaction involving the cardiovascular system, the blood and the lungs.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gutierrez G, Bismar H (1992) Oxygen transport and utilization. In: Dantzker DR (ed) Cardiopulmonary critical care, 2nd edition. WB Saunders, pp 199–229.

    Google Scholar 

  2. Little RA, Denis Edwards J (1993) Applied physiology. In: Edwards JD, Shoemaker WC, Vincent JL (eds) Oxygen transport: principles and practice. WB Saunders, pp 21–40.

    Google Scholar 

  3. Schumaker PT, Cain SM (1987) The concept of a critical oxygen delivery. Intens Care Med 13:223–229.

    Article  Google Scholar 

  4. Myburgh JA (1992) Derived oxygen saturations are not clinically useful for the calculation of oxygen consumption. Anaesth Int Care 20:460–463.

    CAS  Google Scholar 

  5. Myburgh JA, Webb R, Worthley LIG (1992) Ventilation/perfusion indices do not correlate with the difference between oxygen consumption measured by the Fick principles and metabolic monitoring systems in critically patients. Crit Care Med 20:479–482.

    Article  PubMed  CAS  Google Scholar 

  6. Hess D, Kacmarek R (1993) Techniques and devices for monitoring oxygenation. Resp Care 38:646–669.

    Google Scholar 

  7. Light RB (1988) Intrapulmonary oxygen consumption in experimental pneumococcal pneumonia. J Appi Physiol 64:2490–2495.

    CAS  Google Scholar 

  8. Takala J, Keinanen O, Vaisanen P, Kari A (1989) Measurement of gas exchange in intensive care: laboratory and clinical validation of a new device. Crit Care Med 17:1041–1047.

    Article  PubMed  CAS  Google Scholar 

  9. Smithies MN, Royston B, Makita K, Konieczko K, Nunn JF (1991) Comparison of oxygen consumption measurements: indirect calorimetry versus the reverse Fick equation. Crit Care Med 19:1401–1406.

    Article  PubMed  CAS  Google Scholar 

  10. Thrush DN (1996) Spirometrie versus Fick-derived oxygen consumption: which method is better? Crit Care Med 24:91–95.

    Article  PubMed  CAS  Google Scholar 

  11. Stock MC, Ryan ME (1996) Oxygen consumption calculated from the Fick equation has limited utility. Crit Care Med 24:86–90.

    Article  PubMed  CAS  Google Scholar 

  12. Zhang H, Vincent JL (1993) Arteriovenous differences in pC02 and pH are good indicators of critical hypoperfusion. Am Rev Resp Dis 143:867–871.

    Article  Google Scholar 

  13. Bowles SA, Schlichtig R, Kramer DJ, Klions HA (1992) Arteriovenous pH and partial pressure of carbone dioxide detect critical oxygen delivery during progressive hemorrhage in dogs. J Crit Care 7:95–105.

    Article  Google Scholar 

  14. Shibutani K, Komatsu T, Kubal K (1983) Critical level of oxygen delivery in anesthetized man. Crit Care Med 11:640–644.

    Article  PubMed  CAS  Google Scholar 

  15. Rashkin M, Boxkin C, Baughman R (1985) Oxygen delivery in critically ill patients. Relationship to blood lactate and survival. Chest 87:580–584.

    CAS  Google Scholar 

  16. Astiz ME, Rackow EC, Kaufman B, Falk JL, Weil MH (1988) Relationship of oxygen delivery and mixed venous oxygenation to lactic acidosis in patients with sepsis ans acute myocardial infarction. Crit Care Med 16:655–660.

    Article  PubMed  CAS  Google Scholar 

  17. Silance PG, Simon C, Vincent JL (1994) The relation between cardiac index and oxygen extraction in acutely ill patients. Chest 102:1190–1197.

    Article  Google Scholar 

  18. Routsi C, Vincent JL, Bakker J, De Backer D, Lejeune P, D’Hollander A, Le Clerc JL (1993) Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery. Anesth Analg 77:1104–1110.

    Article  PubMed  CAS  Google Scholar 

  19. Zhang H, Vincent JL (1993) Oxygen extraction is altered by endotoxin during tamponade induced stagnant hypoxia. Circ Shock 40:168–176.

    PubMed  CAS  Google Scholar 

  20. Ronco JJ, Fenwick JC, Tweedale MG, Wiggs BR, Phang T, Cooper DJ, Cunningham KF, Russell JA, Walley KR (1993) Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and non septic humans. JAMA 270:1724–1730.

    Article  PubMed  CAS  Google Scholar 

  21. Nelson DP, King CE, Dodd SL, Shumacker PT, Cain SM (1987) Systemic and intestinal limits of 02 extraction in the dog. J Appi Physiol 63:387–392.

    CAS  Google Scholar 

  22. Manthous CA, Hall JB, Kushner R, Schmidt GA, Russo G, Wood LDH (1995) The effect of mechanical ventilation on oxygen consumption in critically ill patients. Am J Resp Crit Care Med 151:210–214.

    PubMed  CAS  Google Scholar 

  23. Manthous CA, Hall JB, Olson D, Singh M, Chatila W, Pohlman A, Kushner R, Schmidt GA, Wood LDH (1995) Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Resp Crit Care Med 151:10–14.

    PubMed  CAS  Google Scholar 

  24. Gutierrez G, Warley AR, Dantzker DR (1986) Oxygen delivery and utilization in hypothermic dogs. J Appi Physiol 60:751–757.

    CAS  Google Scholar 

  25. Schumacker PT, Rowland J, Saltz S, Nelson DP, Wood LDH (1987) Effects of hyperthermia and hypothermia on oxygen extraction by tissues during hypovolemia. J Appi Physiol 63: 1246–1252.

    CAS  Google Scholar 

  26. Gutierrez G, Clark C, Brown SD, Price K, Ortiz L, Nelson C (1994) Effect of dobutamine on oxygen consumption and and gastric mucosal pH in septic patients. Am J Resp Crit Care Med 150:324–329.

    PubMed  CAS  Google Scholar 

  27. Haupt MT, Gilbert EM, Carlson RW (1985) Fluid loading increases oxygen consumption in septic patients with lactic acidosis. Am Rev Respir Dis 131:912–916.

    PubMed  CAS  Google Scholar 

  28. Gilbert EM, Haupt MT, Mandanas RY, Huaringa AJ, Carlson RW (1986) The effect of fluid loading, blood transfusion and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis 134:873–878.

    PubMed  CAS  Google Scholar 

  29. Vincent JL, Roman A, Kahn RJ (1990) Oxygen utake/supply dependency: effects of a short term dobutamine infusion. Am Rev Respir Dis 142:2–7.

    PubMed  CAS  Google Scholar 

  30. Fenwick JC, Dodek PM, Ronco JJ, Phang PT, Wiggs B, Russell JA (1990) Increased concentrations of plasma lactate predict pathologic dependence of oxygen consumption on oxygen delivery in patients with adult respiratory distress syndrome. J Crit Care 5:81–86.

    Article  Google Scholar 

  31. Kruse JA, Haupt MT, Puri VK, Carlson RW (1990) Lactate levels as predictors of the relationship between oxygen delivery and consumption in ARDS. Chest 98:959–962.

    Article  PubMed  CAS  Google Scholar 

  32. Annat G, Viale JP, Carlisle P, Froment M, Motin J (1986) Oxygen delivery and uptake in the adult respiratory distress syndrome-lack of relationship when measured independently in patients with normal blood lactate concentrations. Am Rev Respir Dis 133:999–1001.

    PubMed  CAS  Google Scholar 

  33. Ronco JJ, Phang T, Walley KR, Wiggs B, Fenwick JC, Russell JA (1991) Oxygen consumption is independent of changes in oxygen delivery in severe adult respiratory distress. Am Rev Respir Dis 143:1267–1271.

    PubMed  CAS  Google Scholar 

  34. Vermeiy CG, Feenstra BWA, Adrichem WJ, Bruining HA (1991) Independent oxygen uptake and oxygen delivery in septic and postoperative patients. Chest 99:1438–1443.

    Article  Google Scholar 

  35. Bartlett RH, Dechert RE (1990) Oxygen kinetics: pitfalls in clinical research. J Crit Care 5:77–80.

    Article  Google Scholar 

  36. Nelson DP, Samsel RW, Wood LDH, Schumaker PT (1988) Pathological supply dependence of systemic and intestinal 02 uptake during endotoxemia. J Appi Physiol 64:2410–2419.

    CAS  Google Scholar 

  37. Hotchkiss RS, Karl I (1992) Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 267:1503–1510.

    Article  PubMed  CAS  Google Scholar 

  38. Fedele FA, Gewirtz H, Capone RJ, Sharaf B, Most AS (1988) Metabolic response to prolonged reduction of blood flow distal to a severe coronary stenosis. Circulation 78:729–735.

    Article  PubMed  CAS  Google Scholar 

  39. Apstein CS, Gravino F, Hood WB (1979) Limitation of lactate production as an index of myocardial ischemia. Circulation 60:877–888.

    PubMed  CAS  Google Scholar 

  40. Shaefer S, Schwartz GG, Wisneski JA (1992) Response of high-energy phosphates and lactate release during prolonged regional ischemia in vivo. Circulation 85:342–349.

    Google Scholar 

  41. Rahimtoola SH (1989) The hibernating myocardium. Am Heart J 117:211–221.

    Article  PubMed  CAS  Google Scholar 

  42. Dyffey TE, Nelson SR, Lowry OH (1972) Cerebral carbohydrate metabolism during acute hypoxia and recovery. J Neurochem 19:959–977.

    Article  Google Scholar 

  43. Shumaker PT, Chandel N, Agusti AGN (1993) Oxygen conformance of cellular respiration in hepatocytes. Am J Physiol 265: L395–L402.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Berlot, G., Tomasini, A., Maffessanti, M. (1997). Tissue Oxygenation. In: Pinsky, M.R. (eds) Applied Cardiovascular Physiology. Update in Intensive Care and Emergency Medicine, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60696-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60696-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64512-9

  • Online ISBN: 978-3-642-60696-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics