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Physiology of VO2/DO2

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Applied Cardiovascular Physiology

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 28))

Abstract

Cellular energy is supplied in the form of high energy phosphate compounds, such as ATP, by metabolic reactions involving the oxidation of hydrocarbons. The concentration of ATP in most cells is maintained by the mitochondrial electron transport systems. Under normal conditions the amount of oxygen present in the mitochondria greatly exceeds that required to maintain oxidative phosphorylation. However when oxygen delivery falls, less efficient anaerobic metabolism takes over, leading to lactate production and acidosis. Cellular processes fail as energy supplies fall, and organ system function deteriorates. Oxygen is thus essential for the normal activity and survival of tissues.

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Authors
  1. J.-L. Vincent
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  2. P. van der Linden
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Editor information

Editors and Affiliations

  1. Dept. of Anesthesiology and Critical Care Medicine, University of Pittsburgh, 604 Scaife Hall, Pittsburgh, PA, 15261, USA

    Michael R. Pinsky

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© 1997 Springer-Verlag Berlin Heidelberg

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Vincent, JL., van der Linden, P. (1997). Physiology of VO2/DO2 . In: Pinsky, M.R. (eds) Applied Cardiovascular Physiology. Update in Intensive Care and Emergency Medicine, vol 28. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60696-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-60696-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64512-9

  • Online ISBN: 978-3-642-60696-0

  • eBook Packages: Springer Book Archive

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