Abstract
There is considerable evidence that the Y chromosome encoded testis determining factor, known as SRY, constitutes the primary active binary switch which regulates the transcription of a cascade of genes which in turn direct the development of the primordial gonad into the male testes (Goodfellow and Lovell-Badge 1993; McElreavey et al. 1993; Gustafson and Donahoe 1994; Haqq et al. 1994; Werner et al. 1996a). In the absence of functional SRY, either through mutations in SRY or because of chromosomal makeup (viz. XX females), the primordial gonad develops into ovaries. One potential target for SRY is the promoter for the gene encoding the Müllerian inhibtory substance (MIS) whose product is responsible for the regression of the female Müllerian ducts.
This article is adapted from a review that appeared in Biological Structure and Dynamics (eds. R.H. Sarma and M.H. Sarma), Vol. 1, pp. 35-40, Adenine Press, New York (1996).
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© 1997 Springer-Verlag Berlin Heidelberg
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Clore, G.M., Werner, M.H., Huth, J.R., Gronenborn, A.M. (1997). Understanding SRY-Related 46X,Y Sex Reversal at the Atomic Level. In: Eckstein, F., Lilley, D.M.J. (eds) Mechanisms of Transcription. Nucleic Acids and Molecular Biology, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60691-5_17
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DOI: https://doi.org/10.1007/978-3-642-60691-5_17
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