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Immunoregulatory Genes and Immunosuppression by Glucocorticoids

  • Conference paper

Part of the Archives of Toxicology book series (TOXICOLOGY,volume 19)

Abstract

Glucocorticoids (GCs) are physiological inhibitors of inflammatory responses and are widely used as immunosuppressive and anti-inflammatory agents. GCs induce (i) lymphocyte apoptosis (Cohen, 1989, Galili, 1983) and (ii) inhibit synthesis of lymphokines (Arya et al., 1984, Culpepper and Lee, 1985, Knudsen et al., 1987, Wang et al., 1993, Zanker et al., 1990) and cell surface molecules (Von Knebel et al., 1990) required for immune function. In spite of the widespread use of GCs, the molecular mechanisms that underlie their therapeutic effects are poorly understood.

Keywords

  • Glucocorticoid Receptor
  • Jurkat Cell
  • Transcriptional Interference
  • Immunoregulatory Gene
  • Transfected Jurkat Cell

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1997 Springer-Verlag Berlin Heidelberg

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Auphan, N., Didonato, J.A., Helmberg, A., Rosette, C., Karin, M. (1997). Immunoregulatory Genes and Immunosuppression by Glucocorticoids. In: Seiler, J.P., Vilanova, E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60682-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-60682-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

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