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Genetic Polymorphism of Drug Metabolizing Enzymes. Implications for Toxicity of Drugs and Other Xenobiotics

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Part of the Archives of Toxicology book series (TOXICOLOGY,volume 19)

Abstract

There are pronounced interindividual and interethnic differences in the capacity to metabolize drugs and other xenobiotics. This variation is due to genetic polymorphism of the corresponding genes, as well as to physiological-, environmental- and pathological factors. From a teleological point of view it is evident that genetically based interindividual variability is seen in the human lymphocyte antigen (HLA) system, the immune system and in the inherited defences towards infection by malaria or tuberculosis and that this creates survival of some part of the population during infectious epidemics. In an analogous manner the variability in the drug metabolizing system will be beneficial for survival during chemical catastrophes. In this overview I will focus on the genetic aspects of the drug metabolizing enzymes with emphasis on some P450 forms and the mechanistic basis for their variability. The methods for predicting the genotype of a certain individual and on the possible use of this information in the future will also be considered.

Keywords

  • CYP2D6 Gene
  • CYP2D6 Substrate
  • Interethnic Difference
  • Human Lymphocyte Antigen
  • Altered Substrate Specificity

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1997 Springer-Verlag Berlin Heidelberg

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Ingelman-Sundberg, M. (1997). Genetic Polymorphism of Drug Metabolizing Enzymes. Implications for Toxicity of Drugs and Other Xenobiotics. In: Seiler, J.P., Vilanova, E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60682-3_1

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  • DOI: https://doi.org/10.1007/978-3-642-60682-3_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64505-1

  • Online ISBN: 978-3-642-60682-3

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