Summary
The hypothesis that Alzheimer’s disease is accelerated aging has been tested by comparing the patterns of neuron loss in the hippocampal region associated with normal aging and with Alzheimer’s disease. Qualitative differences were found in the patterns of loss in CA1, indicating that a unique neurodegenerative process not associated with normal aging is involved in Alzheimer’s disease.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
BachmanDL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, White LR, D’Agostino RB (1993) Incidence of dementia and probable Alzheimer’s disease in a general population: The Framingham Study. Neurology 43: 515 – 519
Berg L (1985) Does Alzheimer’s disease represent an exaggeration of normal aging? Arch Neurol 42: 737 – 739
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261: 921 – 923
Hardy J, Mullan M, Chartier-Harlin MC (1991) Molecular classification of Alzheimer’s disease. Lancet 337: 1342
Hyman BT, Van Hoesen GW, Damasio AR (1990) Memory-related neural systems in Alzheimer’s disease: an anatomic study. Neurology 40: 1721 – 1730
Jobst KA, Smith AD, Szatmari M, Esiri MM, Jaskowski A, Hindley N, McDonald B, Molyneux AJ (1994) Rapidly progressing atrophy of medial temporal lobe in Alzheimer’s disease. Lancet 343: 829 – 830
KatzmanR, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, Reubing X, Peck A (1988) Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 23: 138 – 144
Khachaturian ZS (1985) Diagnosis of Alzheimer’s disease. Arch Neurol 42: 1097 – 1105
West MJ, Gundersen HJG (1990) Unbiased stereological estimation of the number of neurons in the human hippocampus. J Compar Neurol 296: 1 – 22
West MJ, Coleman PD, Flood DG, Troncoso JC (1994) Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer’s disease. Lancet 344: 769 – 772
Zola-Morgan S, Squire LR, Amarai DG (1986) Human amnesia and the medial temporal region: Enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci 6: 2950 – 2967
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
West, M.J., Coleman, P.D., Flood, D.G., Troncoso, J.C. (1997). Is Alzheimer’s Disease Accelerated Aging? Different Patterns of Age and Alzheimer’s Disease-Related Neuronal Losses in the Hippocampus. In: Hayman, B.T., Duyckaerts, C., Christen, Y. (eds) Connections, Cognition and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60680-9_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-60680-9_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64504-4
Online ISBN: 978-3-642-60680-9
eBook Packages: Springer Book Archive