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Endopeptidase-24.11/common acute lymphoblastic leukaemia antigen CD10 in Schwann cells: Evidence for a role in nerve development and regeneration

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Molecular Signaling and Regulation in Glial Cells

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Abstract

The regulation of peptide-induced responses in the nervous system is believed to occur through the action of cell-surface peptidases. A key enzyme in this process is endopeptidase-24.11 (E-24.11, EC 3.4.24.11, neprilysin), a 90kD cell surface glycoprotein which has the ability to hydrolyze a large number of physiologically active peptides. The enzyme is found in the nervous system and other peripheral organs and has been shown to be present in the surface membrane of many different cell types (for review see ref. 25). Molecular cloning and sequencing of E-24.11 cDNA from mouse, rat, rabbit and human revealed that it is a type II integral membrane protein which displays 90% identity in amino acid sequence between different species (8,12,31,33,34,48). These studies also demonstrated that E-24.11 is identical to the human common acute lymphoblastic leukemia antigen CD 10 (31).

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  1. Department of Biochemistry, Hellenic Pasteur Institute, 127 Vas. Sofias Avenue, 115 21, Athens, Greece

    Rebecca Matsas & Stathis Meintanis

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  1. Rebecca Matsas
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Editors and Affiliations

  1. FB Biologie/Chemie, Universität Osnabrück, Barbarastr. 11, D-49069, Osnabrück, Germany

    Gunnar Jeserich

  2. Max-Planck-Institut für Experimentelle Medizin, Hermann-Reinsstr. 3, D-37075, Göttingen, Germany

    Hans H. Althaus

  3. FB Biologie, Universität Oldenburg, Postfach 2503, D-26111, Oldenburg, Germany

    Christiane Richter-Landsberg

  4. Molekulare Neurobiochemie, Universität Bochum, Universitätsstr. 150, D-44801, Bochum, Germany

    Rolf Heumann

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Matsas, R., Meintanis, S. (1997). Endopeptidase-24.11/common acute lymphoblastic leukaemia antigen CD10 in Schwann cells: Evidence for a role in nerve development and regeneration. In: Jeserich, G., Althaus, H.H., Richter-Landsberg, C., Heumann, R. (eds) Molecular Signaling and Regulation in Glial Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60669-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-60669-4_4

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