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Aspects of Remyelination by Endogenous and Transplanted Glial Cells in Regenerating Goldfish Visual System

  • S. N. Nona
Conference paper

Abstract

Studies in this laboratory have established that following a crush to goldfish optic nerve, Schwann cells of unknown origin invade the lesion, forming a band of peripheral-type myelin neatly demarcated from the new central-type myelin formal distal to the lesion (7,8). Furthermore, it is clear that such a phenomenon does not take place outside the optic nerve; indeed, neither the lesioned optic tract nor the lesioned spinal cord becomes colonised by Schwann cells, and across both these lesions there is a complete restoration of CNS environment (8,9). In this article, I shall ask what this regional pattern means: is Schwann cell invasion dependent only on there being a local source for these cells, or do astrocyte populations from different regions of CNS differ in their permissiveness to Schwann cell colonisation of damaged CNS tissue?

Keywords

Regeneration CNS astrocytes Schwann cells myelination immunochemistry 

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References

  1. 1.
    Berry, M., Rees. L., Hall, S. (1988) Optic axons regenerate into sciatic nerve isografts only in the presence of Schwann cells. Brain Research Bulletin 20, 223–231.PubMedCrossRefGoogle Scholar
  2. 2.
    Blakemore, W.F. (1976) Invasion of Schwann cells into the spinal cord of the rat following local injection of lysolecithin. Neurpathology and Applied Neurobiology 2, 21–39.CrossRefGoogle Scholar
  3. 3.
    Bronner-Fraser, M. and Fraser, S. (1989) Developmental potential of avian trunk neural crest cells in situ. Neuron 3, 755–766.PubMedCrossRefGoogle Scholar
  4. 4.
    Jeserich, G. and Waehneldt, T.V. (1986) Characterization of antibodies against major fish CNS myelin proteins: immunoblot analysis and immunohistochemical localisation of 36kDa and IP2 proteins in trout nerve tissue. Journal of Neuroscience Research 15, 147–158.PubMedCrossRefGoogle Scholar
  5. 5.
    Mansour, H., Asher, R., Dahl, D., Labkovsky, B., Perides, G. and Bignami, A. (1990) Permissive and non-permissive reactive astrocytes: immunofluorescence study with antibodies to the glial hyaluronate-binding protein. Journal of Neuroscience Research 25, 300–311.PubMedCrossRefGoogle Scholar
  6. 6.
    Nona, S.N., Stafford, C.A., Shehab, S.A.S. and Cronly-Dillon, J.R. (1989) Glial fibrillary acidic protein (GFAP) from goldfish: its localisation in visual pathway. Glia 2, 189–200.PubMedCrossRefGoogle Scholar
  7. 7.
    Nona, S.N., Duncan, A., Stafford, C.A., Maggs, A., Jeserich, G. and Cronly-Dillon, J.R. (1992) Myelination of regenerated axons in goldfish optic nerve by Schwann cells. Journal of Neurocytology 21, 391–401.PubMedCrossRefGoogle Scholar
  8. 8.
    Nona, S.N., Stafford, C.A., Duncan, A., Cronly-Dillon, J.R. and Scholes, J. (1994) Myelin repair by Schwann cells in the regenerating goldfish visual pathway: regional patterns revealed by X-irradiation. Journal of Neurocytology 23, 400–409.PubMedCrossRefGoogle Scholar
  9. 9.
    Nona, S.N. and Stafford, C.A. (1995) Glial repair at the site of lesion in regenerating goldfish spinal cord: an immunohistochemical study using species-specific antibody. Journal of Neuroscience Research. In press.Google Scholar
  10. 10.
    Reier, P.J., Stensaas, L.J. and Guth, L. (1983) The astrocytic scar as an impediment to regeneration in the central nervous system. In C.C.Kao, R.P.Bunge and P.J.Reier (eds), Spinal Cord Reconstruction, Raven Press, New York, pp 163–196.Google Scholar
  11. 11.
    Richardson, P.M., McGuiness, V.M. and Aguayo, A.J. (1980) Axons fom CNS neurones regenerate into PNS grafts. Nature 284, 264–265.PubMedCrossRefGoogle Scholar
  12. 12.
    Schwab, M. (1990) Myelin associated inhibitors of neurite growth. Experimental Neurology 109, 2–5.PubMedCrossRefGoogle Scholar
  13. 13.
    Sims, T.J. and Gilmore, S.A. (1989) Interaction between Schwann cells and CNS axons following a delay in the normal formation of central myelin. Experimental Brain Research 75, 513–522.CrossRefGoogle Scholar
  14. 14.
    Sivron, T. and Schwartz, M. (1994) The enigma of myelin- associated growth inhibitors in spontaneously regenerating nervous system. Trends in Neurosciences 17, 277–281.PubMedCrossRefGoogle Scholar
  15. 15.
    Snow, D.M., Lemmon, V., Carrino, D.A., Caplan, A.I. and Silver, J. (1990) Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Experimental Neurology 109, 111–130.PubMedCrossRefGoogle Scholar
  16. 16.
    Stafford, C.A., Shehab, S.A.S., Nona, S.N. and Cronly-Dillon, J.R. (1990) Expression of glial fibrillary acidic protein (GFAP) in goldfish optic nerve following injury. Glia 3, 33–42.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • S. N. Nona
    • 1
  1. 1.Developmental Neurobiology Laboratory, Dept. Optometry &Vision SciencesUMISTManchesterUK

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