Aspects of Remyelination by Endogenous and Transplanted Glial Cells in Regenerating Goldfish Visual System
Studies in this laboratory have established that following a crush to goldfish optic nerve, Schwann cells of unknown origin invade the lesion, forming a band of peripheral-type myelin neatly demarcated from the new central-type myelin formal distal to the lesion (7,8). Furthermore, it is clear that such a phenomenon does not take place outside the optic nerve; indeed, neither the lesioned optic tract nor the lesioned spinal cord becomes colonised by Schwann cells, and across both these lesions there is a complete restoration of CNS environment (8,9). In this article, I shall ask what this regional pattern means: is Schwann cell invasion dependent only on there being a local source for these cells, or do astrocyte populations from different regions of CNS differ in their permissiveness to Schwann cell colonisation of damaged CNS tissue?
KeywordsRegeneration CNS astrocytes Schwann cells myelination immunochemistry
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