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Thromboxane A2 and Other Eicosanoids

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Platelets and Their Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 126))

Abstract

The major product of the metabolism of arachidonic acid in platelets is thromboxane A2 (TXA2) (Hamberg et al. 1975); thus, the main focus of this chapter will be on it. The effects of other eicosanoids that are either synthesized by platelets or impact on platelet function will also be discussed. TXA2 receptors are discussed in greater detail in Chap. 7B. We will provide a brief discussion of alterations in platelet TXA2 receptors in disease states. A comprehensive review of the effects of TXA2 on platelet function was provided by Arita et al. (1989). This review will focus on discoveries made since then.

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Authors
  1. P. V. Halushka
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  2. S. Pawate
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  3. M. L. Martin
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Editors and Affiliations

  1. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 69-73, 14195, Berlin, Germany

    Franz von Bruchhausen

  2. Institut für Klinische Biochemie und Pathobiochemie, Medinzinische Universitätsklinik, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Ulrich Walter

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Halushka, P.V., Pawate, S., Martin, M.L. (1997). Thromboxane A2 and Other Eicosanoids. In: von Bruchhausen, F., Walter, U. (eds) Platelets and Their Factors. Handbook of Experimental Pharmacology, vol 126. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60639-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-60639-7_21

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