• Uwe Wollina
  • Thomas Bocker
  • Elena Castelli


Talgdrüsen entwickeln sich ontogenetisch aus den primitiven Haar-Talgdrüsen-Einheiten der Haarbündel, welche beim Menschen überwiegend aus einem Haupt- und zwei Beihaaren bestehen [66, vgl. 85]. Prinzipiell gelten ähnliche Verhältnisse auch für den Vellushaarfollikel [7]. Aus einem epithelialen Follikelkragen bildet sich die Anlage, aus welcher Talgdrüsen entstehen können [106]. Die funktionelle Intaktheit der Talgdrüsen ist an die physiologische Ausprägung des Haares geknüpft. Kommt es zur sekundären Degeneration der Haarfollikel, bilden sich auch Talgdrüsen zurück [74].


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  1. 1.
    Al-Sarraf M (1994) Head and neck cancer treatment: present status and future direction. In: Banzet P, Holland JF, Khayat D, Weil M (eds) Cancer Treatment — An Update (PP186–190). Springer, Berlin Heidelberg New York Tokyo ParisGoogle Scholar
  2. 2.
    Anttila HSI, Reitamo S, Saurat J-H (1992) Interleukin 1 immunoreactivity in sebaceous glands. Br J Dermatol 127: 585–588PubMedGoogle Scholar
  3. 3.
    Argenyi ZB (1995) Sebaceous epithelioma. In: Hügel H, Kutzner H, Rütten A, (Hrsg) Dermatologisches Schnittseminar am Bodensee (Skripte) (S 43–44). SelbstverlagGoogle Scholar
  4. 4.
    Ashinoff R (1993) Linear nevus sebaceus of Jadassohn treted with the carbon dioxide laser. Pediatr Dermatol 10: 189–191PubMedGoogle Scholar
  5. 5.
    Barth JH, Dawber RPR (1987) Focal naevoid hypotrichosis. Acta Derm Venereol (Stockh) 67: 178–179Google Scholar
  6. 6.
    Bailet JW, Zimmerman MC, Arnstein DP, Wollman JS, Mickel RA (1992) Sebaceous carcinoma of the haed and neck: case report and literature review. Arch Otolaryngol Head Neck Surg 118: 1245–1249PubMedGoogle Scholar
  7. 7.
    Blume U, Ferracin J, Verschoore M, Czernielewski JM, Schaefer H (1991) Physiology of the vellus hair follicle: hair growth and sebum excretion. Br J Dermatol 124: 21–28PubMedGoogle Scholar
  8. 8.
    Bollag W, Holdener EE (1992) Retinoids in cancer prevention and therapy. Ann Oncol 3: 513–526PubMedGoogle Scholar
  9. 9.
    Bouwes Bavinck JN, Kamp JJP van de(1985) Organoid naevus phakomatosis: Schimmelpenning-Feuerstein-Mims syndrome. Br J Dermatol 113: 491–492Google Scholar
  10. 10.
    Braun-Falco O, Plewig G, Wolff HH, (1996) Dermatologie und Venerologie. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  11. 11.
    Braun-Falco O, Thianprasit M (1965) Über die circumscripte senile Talgdrüsenhyperplasie. Arch Klin Exp Dermatol 221: 207–231PubMedGoogle Scholar
  12. 12.
    Brownstein MH (1982) Steatocystoma simplex. A solitary steatocystoma. Arch Dermatol 118: 409–411PubMedGoogle Scholar
  13. 13.
    Burgdorf WHC (1990) Tumors of sebaceous gland differentiation. In: Farmer ER, Hood AF (eds) Pathology of the Skin (pp 615–623). Appleton & Lange, NorwalkGoogle Scholar
  14. 14.
    Busch S, Altmeyer P (1994) Schimmelpenning-Feuerstein-Mims-Syndrom (SFM-Syndrom). Hautarzt 45: 719–724PubMedGoogle Scholar
  15. 15.
    Cohen PR, Cohn SR, Kurzrock R (1991) Association of sebaceous gland tumors and internal malignancy: the Muir-Torre-syndrome. Am J Med 90: 606–613PubMedGoogle Scholar
  16. 16.
    Cohen PR, Kohn SR, Davis DA, Kurzrock R (1995) Muir-Torre syndrome. Dermatol Clin 13: 79–89PubMedGoogle Scholar
  17. 17.
    Daley TD (1993a) Pathology of intraoral sebaceous glands. J Oral Pathol Med 22: 241–245PubMedGoogle Scholar
  18. 18.
    Daley TD (1993b) Intraoral sebaceous hyperplasia. Oral Surg Oral Med Oral Pathol 74: 343–347Google Scholar
  19. 19.
    Daskalopoulou D, Maounis N, Kokalis G, Liodandonaki P, Belezini E (1993) The role of fine needle aspiration cytology in the diagnosis of primary skin tumors. Arch Anat Cytol Pathol 41: 75–81PubMedGoogle Scholar
  20. 20.
    Dent CD, Hunter WE, Svirsky JA (1995) Sebaceous gland hyperplasia. J Oral Maxillofac Surg 53: 936–938PubMedGoogle Scholar
  21. 21.
    De Potter P, Shields CL, Shields JA (1993) Sebaceous gland carcinoma of the eyelids. Int Ophthalmol Clin 33: 5–9PubMedGoogle Scholar
  22. 22.
    Dinnen AM, Mehregan DR (1996) Sebaceous epithelioma: a review of twenty-one cases. J Am Acad Dermatol 34: 47–50Google Scholar
  23. 23.
    Dodge NN, Dobyns WB (1995) Agenesis of the corpus callosum and Dandy-Walker malformation associated with hemimegalencephaly in the sebaceous nevus syndrome. Am J Med Genet 56: 147–152PubMedGoogle Scholar
  24. 24.
    Fernandez N, Torres A (1984) Hyperplasia of sebaceous glands in a linear pattern of papules. Report of four cases. Am J Dermatopathol 6: 237–243PubMedGoogle Scholar
  25. 26.
    Fewkes JL, Cheney ML, Pollack V (1992) Illustrated Atlas of Cutaneous Surgery. Lippincott, Philadelphia/Gower, New YorkGoogle Scholar
  26. 27.
    Fogt F, Tahan SR (1993) Cutaneous hamartoma of adnexa and mesenchyme: a variant of folliculosebaceous cystic hamartoma with vascular-mesenchymal overgrowth. Am J Dermatopathol 15: 73–76PubMedGoogle Scholar
  27. 28.
    Ghadially FN (1961) The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals. Cancer 14: 801–816PubMedGoogle Scholar
  28. 29.
    Gentry Jr WC (1990) Paraneoplastic syndromes. In: Sams WM Jr, Lynch PJ (eds) Principles and practice of dermatology (pp 715–721). Churchill Livingstone, New YorkGoogle Scholar
  29. 30.
    Gollnick H, Orfanos CE (1991) Theoretical aspects of the use of retinoids as anticancer agents. In: Marks R (ed) Retinoids in Cutaneous Malignancy (pp 41–65). Blackwell, OxfordGoogle Scholar
  30. 32.
    Hall NR, Murday VA, Chapman P, Williams MA, Burn J, Finan PJ, Bishop DT (1994) Genetic linkage in Muir-Torre syndrome to the same chromosomal region as cancer family syndrome. Eur J Cancer 30A: 180–182PubMedGoogle Scholar
  31. 33.
    Happle R (1995) Epidermal nevus syndromes. Semin Dermatol 14: 111–121PubMedGoogle Scholar
  32. 34.
    Hartig C, Stieler W, Stadler R (1995) Muir-Torre-Syndrom. Hautarzt 46: 107–113PubMedGoogle Scholar
  33. 35.
    Hashimoto K (1991) Adnexal carcinoma of the skin. In: Friedman RJ, Rigel DS, Kopf AW, Harris MN, Baker D (eds) Cancer of the Skin (pp 209–216). Saunders, PhiladelphiaGoogle Scholar
  34. 37.
    Hashimoto K, Kanzaki T (1984) Appendage tumors of the skin: histogenesis and ultrastructure. J Cutan Pathol 11: 365–381PubMedGoogle Scholar
  35. 38.
    Hashimoto K, Mehregan AH, Kumakiri M (1987) Tumors of Skin Appendages. Butterworths, BostonGoogle Scholar
  36. 40.
    Hasebe T, Mukai K, Yamaguchi N, Ishihara K, Kaneko A, Takasaki Y, Shimosato Y (1994) Prognostic value of immunohistochemical staining for proliferating cell nuclear antigen, p53, and c-erbB-2 in sebaceous gland carcinoma and sweat gland carcinoma: comparision with histopathological parameter. Mol Pathol 7: 37–43Google Scholar
  37. 41.
    Hayashi N, Furihata M, Ohtsuki Y, Ueno H (1994) Search for accumulation of p53 protein and detection of human papillomavirus genomes in sebaceous gland carcinoma of the eyelid. Virchows Arch 424: 503–509PubMedGoogle Scholar
  38. 42.
    Honchel R, Halling KC, Schaid DJ, Pittelkow M, Thibodeau SN (1994) Micro satellite instability in Muir-Torre syndrome. Cancer Res 54: 1159–1163PubMedGoogle Scholar
  39. 43.
    Jansen T, Brandl G, Bandmann M, Meurer M (1995) Pachydermoperiostose. Hautarzt 46: 429–435PubMedGoogle Scholar
  40. 44.
    Jerasutus S, Suvanprakorn P, Sombatworapat W (1989) Eruptive vellus hair cyst and steatocystoma multiplex. J Am Acad Dermatol 20: 292–293PubMedGoogle Scholar
  41. 45.
    Jordan DR, McDonald H, Anderson RL (1994) Irridiated homologous aorta in eyelid reconstruction. Part II. Human data. Ophthal Plast Reconstr Surg 10: 227–233PubMedGoogle Scholar
  42. 46.
    Kodsi SR, Bloom KE, Egbert JE, Holland EJ, Cameron JD (1994) Ocular and systemic manifestations of encephalocraniocutaneous lipomatosis. Am J Ophthal 118: 77–82PubMedGoogle Scholar
  43. 47.
    Kücüködük S, Özsan H, Turanli AY, Dine H, Selcuk M (1993) A new neurocutaneous syndrome: nevus sebaceus syndrome. Cutis 51: 437–441PubMedGoogle Scholar
  44. 48.
    Kuflik EG, Gage AA (1990) Cryosurgical Treatment for Skin Cancer. Igaku-Shoin, New York TokyoGoogle Scholar
  45. 49.
    Kumar P, Marks R (1987) Sebaceous gland hyperplasia and senile comedones: A prevalance study in elderly hospitalized patients. Br J Dermatol 117: 231–236PubMedGoogle Scholar
  46. 50.
    Kurokawa I, Mayer-da-Silva A, Gollnick H, Orfanos CE (1988) Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrheic and acne skin. J Invest Dermatol 91: 566–571PubMedGoogle Scholar
  47. 51.
    Lever L, Marks R (1991) Topical retinoid treatment for skin cancer: a review. Skin Pharmacol 4: 125–131PubMedGoogle Scholar
  48. 52.
    Lim RY (1994) Contact Nd:YAG laser excision of rhinophyma. W V Med J 9: 62–63Google Scholar
  49. 53.
    Luderschmidt C, Plewig G (1985) Circumscribed sebaceous gland hyperplasia: autoradiographic and histoplanometric studies. J Invest Dermatol 70: 207–209Google Scholar
  50. 54.
    Matsumoto CS, Nakatsuka K, Matsuo K, Yatsuka H, Monzen Y (1995) Sebaceous carcinoma responds to radiation therapy. Ophthalmologica 209: 280–283PubMedGoogle Scholar
  51. 55.
    Mayou SC, Benn JJ, Sonksen PH, Black MM (1989) Paraneoplastic rhinophyma and the Leser-Trélat sign. Clin Exp Dermatol 14: 253–255PubMedGoogle Scholar
  52. 56.
    Mehregan AH (1985) The origin of the adnexal tumors of the skin: a viewpoint. J Cutan Pathol 12: 459–467PubMedGoogle Scholar
  53. 57.
    Mehregan AH, Pinkus H (1965) Life history of organoid nevi: special reference to nevus sebaceus of Jadassohn. Arch Dermatol 91: 574–588PubMedGoogle Scholar
  54. 58.
    Mehregan AH, Hashimoto K (1991) Nevus sebaceous and sebaceous tumors, basal cell epithelioma. In: Mehregan AH, Hashimoto K (eds) :Pinkus’ Guide to Dermatohistology (5th edn; pp 523–529, 583–601). Appleton & Lange, NorwalkGoogle Scholar
  55. 59.
    Meier-Gibbsons F, Messmer E (1994) Sebaceous gland adenoma of the palpebral conjunctiva in a patient with Muir-Torre-Syndrome: a case report. Gräfes Arch Clin Exp Ophthalmol 232: 734–736Google Scholar
  56. 60.
    Misago N, Narisawa Y, Takahisa N, Kohda H (1994) Association of nevus sebaceus with an unusual type of „combined nevus“. J Cutan Pathol 21: 76–81PubMedGoogle Scholar
  57. 61.
    Monk BE, Vollum DI (1982) Familial naevus sebaceous. J Roy Soc Med 75: 660–661PubMedGoogle Scholar
  58. 62.
    Montagna W, Yun JS (1972) The glands of Montgomery. Br J Dermatol 86: 126–133PubMedGoogle Scholar
  59. 63.
    Moon SE, Lee YS, Youn JI (1994) Eruptive vellus hair cyst and steatocystoma multiplex in a patient with pachyonychia congenita. J Am Acad Dermatol 30: 375–376Google Scholar
  60. 64.
    Muir EG, Bell AJY, Barlow KA (1967) Multiple primary carcinomata of the colon, duodenum, and larynx associated with keratoacanthoma of the face. Br J Surg 54: 191–195Google Scholar
  61. 65.
    Nakamura S, Toyoda K (1994) A case of giant sebaceoma on the head. J Dermatol 21: 367–369PubMedGoogle Scholar
  62. 66.
    Oberste-Lehn H (1958) Haarordnung bei Mensch und Säugetier. Bericht über die 6. Tagung der Deutschen Gesellschaft für Anthropologie. Musterschmidt Verlag, Göttingen, S 75–82Google Scholar
  63. 67.
    Omura EF (1990) Paraneoplastic syndromes. In: Sams WM Jr, Lynch PJ (eds) Principles and Practice of Dermatology (pp 247–255). Churchill Livingstone, New YorkGoogle Scholar
  64. 68.
    Oranje AP, Przyrembel MD, Meradji M, Loonen MC, Clark JB de (1994) Solomon’s epidermal nevus syndrome (type: linear nevus sebaceus) and hypophosphatemic vitamin D-resistant rickets. Arch Dermatol 130: 1167–1171PubMedGoogle Scholar
  65. 69.
    Orfanos CE, Garbe C (1995) Therapie der Hautkrankheiten. Springer, Berlin Heidelberg New York TokyoGoogle Scholar
  66. 70.
    Palazzi P, Artese O, Paolini A, Cazzato C, Cucchiarelli S, Iezzi D, Amerio P (1996) Linear sebaceous nevus syndrome: report of a patient with unusual associated abnormalities. Pediatr Dermatol 13: 22–24PubMedGoogle Scholar
  67. 71.
    Pickford MA, Hogg FJ, Fallowfield ME, Webster MH (1995) Sebaceous carcinoma of the periorbital and extraorbital regions. Br J Plast Surg 48: 93–96PubMedGoogle Scholar
  68. 72.
    Plewig G (1980) Sebaceous trichofolliculoma. J Cutan Pathol 7: 394–403PubMedGoogle Scholar
  69. 73.
    Plewig G, Wolff HH, Braun-Falco O (1982) Steatocystoma multiplex: anatomic réévaluation, electron microscopy and autoradiography. Arch Dermatol Res 272: 363–380PubMedGoogle Scholar
  70. 74.
    Prinzhorn F (1920/21) Die Haut und die Rückbildung der Haare beim Nackthunde. Jenaische Z Naturwiss 57/NF 50: 143–198Google Scholar
  71. 75.
    Requena L, Martin L, Renedo G, Arias D, Espinel ML, Castro A de (1993) A facial variant of steatocystoma multiplex. Cutis 51: 449–452PubMedGoogle Scholar
  72. 76.
    Rodriguez-Sains RS (1991) The role of the ophthalmologist in management of skin cancers. In: Friedman RJ, Rigel DS, Kopf AW, Harris MN, Baker D (eds) Cancer of the Skin (pp 589–610). Saunders, PhiladelphiaGoogle Scholar
  73. 77.
    Sanchez-Yus E, Montull C, Valcayo A, Robledo A (1988) Aereolar [sic] sebaceous hyperplasia: a new entity? J Cutan Pathol 15: 62PubMedGoogle Scholar
  74. 78.
    Sato K, Kubota T, Kitai R (1994) Linear sebaceous nevus syndrome (sebaceous nevus of Jadassohn) associated with abnormal neuronal migration and optic glioma: case report. Neurosurgery 35: 318–320PubMedGoogle Scholar
  75. 79.
    Sato K, Shibuya K, Tagucchi H, Kitano Y (1993) Aspiration therapy in steatocystoma multiplex. Arch Dermatol 129: 35–37PubMedGoogle Scholar
  76. 80.
    Sawaya ME, Penneys NS (1991) Immunohistochemical distribution of aromatase and 3B-hydroxysteroid dehydrogenase in human hair follicle and sebaceous gland. J Cutan Pathol 19: 309–314Google Scholar
  77. 81.
    Schmoeckel C (1994) Lexikon und Differentialdiagnose der klinischen Dermatologie. Thieme, Stuttgart New York, S 619–621Google Scholar
  78. 82.
    Schwartz RA, Torre P (1995) The Muir-Torre syndrome: a 25-year retrospect. J Am Acad Dermatol 33: 90–104PubMedGoogle Scholar
  79. 83.
    Spielvogel R, DeVillez RL, Roberts LC (1985) Oral isotretinoin therapy for familial Muir-Torre syndrome. J Am Acad Dermatol 12: 475–480PubMedGoogle Scholar
  80. 84.
    Steffen C, Ackerman AB (1994) Neoplasms with Sebaceous Differentiation. Lea & Febiger, PhiladelphiaGoogle Scholar
  81. 85.
    Strauss JS, Pochi PE (1968) Histology, histochemistry and electron microscopy of sebaceous glands in man. In: Gans 0, Steigleder GK (Hrsg) Normale und pathologische Anatomie der Haut. (Handbuch der Haut- und Geschlechtskrankheiten. J. Jadassohn Ergänzungswerk. Bd 1/1, S 217–218). Springer, Berlin Heidelberg New YorkGoogle Scholar
  82. 86.
    Tarkhan II. Domingo J (1985) Metastasizing eccrine porocarcinoma developing in a sebaceous nevus Jadassohn. Arch Dermatol 121: 413–415PubMedGoogle Scholar
  83. 87.
    Tazawa T, Fujiwara H, Ito M, Sato Y (1990) Immunohistochemical study on differentiations of carcinomas of the skin using antikeratin monoclonal antibodies. Acta Med Biolog 38: 75–84Google Scholar
  84. 88.
    Templeton SF (1996) Folliculosebaceous cystic hamartoma: a clinical pathologic study. J Am Acad Dermatol 34: 77–81PubMedGoogle Scholar
  85. 89.
    Thody AJ, Shuster S (1989) Control and function of sebaceous glands. Physiol Rev 69: 383–416PubMedGoogle Scholar
  86. 90.
    Torre D (1968) Multiple sebaceous tumors. Arch Dermatol 98: 549–552PubMedGoogle Scholar
  87. 91.
    Troy JL, Ackerman AB (1984) Sebaceoma, a distinctive benign neoplasma of adnexal differentiating toward sebaceous cells. Am J Dermatopathol 6: 7–13PubMedGoogle Scholar
  88. 92.
    Tsuji T, Yamauchi R (1994) Areolar sebaceous hyperplasia with a Fordyce’s spot-like lesion. J Dermatol 21: 524–526PubMedGoogle Scholar
  89. 93.
    Valcuen De Cavero F, Castells Rodellas A (1990) Aportación al estudio de los tumores anexiales benignos. Actas Dermo-Sif 81: 99–111Google Scholar
  90. 94.
    Van der Putte P (1994) Apoeccrine glands in nevus sebaceus. Am J Dermatopathol 16: 23–30PubMedGoogle Scholar
  91. 95.
    Verlooy H, Mortelmans L, Schlepers C de Roo (1993) A rare case of sebaceous carcinoma with very malignant characteristics. Clin Nucl Med 18: 425–427PubMedGoogle Scholar
  92. 96.
    Wallace ML, Smoller BR (1996) Immunohistochemistry in diagnostic dermatopathology. J Am Acad Dermatol 34: 163–183PubMedGoogle Scholar
  93. 97.
    Watanabe R, Kawai K, Ito M, Ito K, Ikeda K (1994) Sebacous epithelioma. J Dermatol 21: 35–41PubMedGoogle Scholar
  94. 98.
    Werner S, Stuhlert A, Wollina U (1995) Skrotalzysten bei Sturge-Weber-Syndrom. Z Hautkrankh 70: 31–34Google Scholar
  95. 99.
    Wollina U (1996) Rhinophyma — unusual expression of simple-type keratins and S100A in sebocytes and abundance of VIP recceptor positive dermal cells. Histol Histopathol 11: 111–115PubMedGoogle Scholar
  96. 100.
    Wollina U (1993) Diversity of epithelial skin tumors: thoughts and comments on some basic principles. In: Hecker E, Jung EG, Marks F, Tilgen W (eds) Skin carcinogenesis in man and in experimental models. Recent Results Cancer Res 128: 153–178Google Scholar
  97. 101.
    Wollina U, Lange D, Fuña K, Paus R (1996) Expression of transforming growth factor b isoforms and their receptors during hair growth phases in mice. Histol Histopathol 11: 431–436PubMedGoogle Scholar
  98. 102.
    Wollina U, Paus R, Feldrappe S (1995) Sequential expression of glutathione-S-transferase isoenzymes during anagen hair growth in mice and their relationship to phosphotyrosinase and VIP receptor. Histol Histopathol 10: 39–45PubMedGoogle Scholar
  99. 103.
    Wollina U, Rülke D, Schaarschmidt H (1992) Distribution of calmodulin-immunoreactivity (CaM-IR) and neuroglandular antigen among adnexal tumors of skin. Eur J Dermatol 2: 435–439Google Scholar
  100. 104.
    Wollina U, Schaarschmidt H, Hipler C, Knopf B (1989) Distribution of glycoconjugates in human skin appendages. Acta Histochem 87: 87–93PubMedGoogle Scholar
  101. 105.
    Wollina U, Karte K (1997) Acitretin in diffuse sebaceous gland hyperplasia, photodamaged skin and alopecia. Report of a case with chondroma of the lung. An bras Dermatol (Rio de Janeiro) 72: in pressGoogle Scholar
  102. 106.
    Zimmermann KW (1935) Über einige Formverhältnisse der Haarfollikel des Menschen. Z Mikrosk-Anat Forsch 38: 503–553Google Scholar

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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Uwe Wollina
  • Thomas Bocker
  • Elena Castelli

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