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Ontogeny of Human Natural and Acquired Immunity

  • Chapter
Reproductive Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 222))

Abstract

In many species, the integrity of the body against bacterial and viral infections is preserved during perinatal life by the development of specialized organs and differentiation of a variety of immunological competent cells together with the temporary acquisition of maternally derived antibodies. The ontogeny of the immune system is a complex process that requires the maturation of many cells with different biological functions and the synthesis of a large number of proteins acting, for example, as ligands, receptors, transport, or lytic molecules.

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References

  • Abo T, Cooper MD, Bach CM(1982) Postnatal expansion of the natural killer and killer cell populations in humans identified by the monoclonal NHK-1 antibody. J Exp Med 155:321–326

    PubMed  CAS  Google Scholar 

  • Adams JC, Watt FM(1993) Regulation of development and differentiation by the extracellular matrix. Development 117:1183–1198

    PubMed  CAS  Google Scholar 

  • Adinolfi M(1965) Anti-I antibodies in normal human newborn infants. Immunology 9:43–52

    PubMed  CAS  Google Scholar 

  • Adinolfi M(1972) Ontogeny of components of complement and lysozyme. Ciba Found Symp, pp 65 - 81

    Google Scholar 

  • Adinolfi M(1974) The development of lymphoid tissues and immunity. In:Davis J A, Dobbing J(eds) Scientific foundation of paediatrics. Heineman, New York, pp 333–348

    Google Scholar 

  • Adinolfi M(1976) Inhibition of mitosis of maternal lymphocytes by fetal cells. Lancet i:97

    Google Scholar 

  • Adinolfi M(1977) Human complement:onset and site of synthesis during fetal life. Am J Dis Child 131:1015–1023

    PubMed  CAS  Google Scholar 

  • Adinolfi M(1981a) The development of lymphoid tissues and immunity. In:Davis JA, Dobbing J(eds) Scientific foundations of paediatrics. Heinemann, London, pp 525–544

    Google Scholar 

  • Adinolfi M(1981b) Ontogeny of complement, lysozyme and lactoferrin in man. In:Lambert HP, Wood CBC(eds) Immunological aspects of infections in the fetus and newborn. Academic, London, pp 19 –52

    Google Scholar 

  • Adinolfi M(1982) Two aspects of the materno-fetal relation:the immunosuppressive role of a-fetoprotein and the transfer of lymphocytes across the placenta. In:Shulman S, Doudero F, Nicotra M(eds) Immunological factors in human reproduction, Serono symposia 45. Academic, London, pp 199–219

    Google Scholar 

  • Adinolfi M(1988) New and old aspects of the ontogeny of immune responses. In Stem CMM(ed) Immunology of pregnancy and its disorders. Kluwer Academic, New York, pp 33–59

    Google Scholar 

  • Adinolfi M(1993a) Ontogeny and phylogeny of complement. In:Cooper EL, Nisbet-Brown E(eds) Developmental immunology. Oxford University Press, Oxford, pp 290–314

    Google Scholar 

  • Adinolfi M(1993b) Infectious diseases in pregnancy, cytokines and neurological impairment:an hypothesis. Dev Med Child Neurol 35:549–558

    Google Scholar 

  • Adinolfi M, Beck S(1976) Human complement C7 and C9 in fetal and newborn sera. Arch Dis Child 50:562–564

    Google Scholar 

  • Adinolfi M, Glynn A(1979) The interaction of antibacterial factors in breast milk. Dev Med Child Neurol 21:808–819

    PubMed  CAS  Google Scholar 

  • Adinolfi M, Lehner T(1988) C9 and factor B as acute phase proteins and their diagnostic and prognostic value in disease. Exp Clin Immunogenet 5:123–132

    PubMed  CAS  Google Scholar 

  • Adinolfi M, Wood C(1969) Ontogenesis of immunoglobulins and components of complement in man. In:Immunology and development. Spastics International Medical, London, pp 27–61

    Google Scholar 

  • Adinolfi M, Gardner B, Wood CBS(1968) Ontogenesis of two components of human complement. β 1 E and β1C-1A globulins. Nature 319:189–191

    Google Scholar 

  • Adinolfi M, Martin W, Glynn A(1971) Ontogenesis of lysozyme in man and other mammals. In:Peeters H(ed) Protides of the biological fluids. Proceedings of the 18th colloquium, Bruges, 1970. Pergamon, New York, pp 91–93

    Google Scholar 

  • Adinolfi M, Cheetham M, Lee T, Rodin A(1988) Ontogeny of human complement receptors CR1 and CR3:expression of these molecules on motocytes and neutrophils from maternal, newborn and fetal samples. Eur J Immunol 18:565–569

    PubMed  CAS  Google Scholar 

  • Aho K, Palosuo T, Andersson M, Turunen H, Terho P, Vesikari T, Leinikki P(1987) Raised acute-phase glycoprotein and IgM levels in cord serum. Gynecol Obstet Invest 24:50–55

    PubMed  CAS  Google Scholar 

  • Alford CA Jr(1965) Studies on antibody in congenital rubella infection. I. Physico-chemical and immunologic investigation of rubella neutralizing antibody. Am J Dis Child 110:455–463

    PubMed  CAS  Google Scholar 

  • Alford CA, Schaefer J, Blankenship WJ, Straumljord JV, Cassidy G(1967) A correlative immunologic, microbiologic and clinical approach to the diagnosis of acute and chronic infections in newborn infants. N Engl J Med 277:437–449

    PubMed  CAS  Google Scholar 

  • Alt FW, Blackwell TK, Yancopoulos GD(1987) Development of the primary antibody repertoire. Nature 328:1079–1087

    Google Scholar 

  • Alt FW, Oltz Em, Young F, Gorman J, Taccioli G, Chen J(1992) VDJ recombination. Immunol Today 13:306–314

    PubMed  CAS  Google Scholar 

  • Andersson U(1985) Development of B lymphocyte function in childhood. Acta Paediatr Scand 74:568–573

    PubMed  CAS  Google Scholar 

  • Andersson U(1987) Regulation of antibody synthesis in the neonate. In:Burgio GR, Hayson LA, Ungazio AG(eds) Immunology of the neonate. Springer, Berlin Heidelberg New York, pp 37–50

    Google Scholar 

  • Andersson U, Bird AG, Britton S(1981) Humoral and cellular immunity in humans studied at the cell level from birth to two years of age. Immunol Rev 57:5–37

    Google Scholar 

  • Andre C, Heremans JF, Vaerman JP, Cambiaso CL(1975) A mechanism for the induction of immunological tolerance by antigen feeding:antigen-antibody complexes. J Exp Med 142:1509–1519

    PubMed  CAS  Google Scholar 

  • Arditi E, Nigro N(1957) Ricerche sul comportamento serico nelFimmaturo. Minerva Pediatr 9:921–928

    PubMed  CAS  Google Scholar 

  • Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher H-P, Zinkernagel RM, Tonegawa S(1994) Evidence for a differential avidity model of T cell selection in the thymus. Cell 76:651–663

    PubMed  CAS  Google Scholar 

  • Barbouche R, Forveille M, Fischer A, Avrameas S, Durandy A(1992) Spontaneous IgM autoantibody production in vitro by B lymphocytes of normal human neonates. Scand J Immunol 35:659–667

    PubMed  CAS  Google Scholar 

  • Belmont JW(1995) Insights into lymphocyte development from X-linked immune deficiencies. Trends Genet 11:112–116

    PubMed  CAS  Google Scholar 

  • Bhoopat L, Taylor CR, Hofman FM(1986) The differentiation of antigens of macrophages in human fetal liver. Clin Immunol Immunopathol 41:184–192

    PubMed  CAS  Google Scholar 

  • Bianco C, Patrick R, Nussenzweig V(1970) A population of lumphocytes bearing a membrane receptor for antigen-antibody-complement complexes:I. Separation and characterization. J Exp Med 132:702–720

    PubMed  CAS  Google Scholar 

  • Bierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ(1989) The biologic roles of CD2, CD4, and CD8 in T cell activation. Annu Rev Immunol 7:579–599

    PubMed  CAS  Google Scholar 

  • Billingham RE, Brent L, Medawar PB(1953) Actively acquired tolerance of foreign cells. Nature 172:603–606

    PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Perham P(1990) Structure, function and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem 59:253–288

    PubMed  CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC(1987a) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329:506–512

    CAS  Google Scholar 

  • Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC(1987b) The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512–518

    CAS  Google Scholar 

  • Blackman M, Kappler J, Marrack P(1990) The role of the T cell receptor in positive and negative selection of developing T cells. Science 248:1335–1341

    PubMed  CAS  Google Scholar 

  • Blackwell KT, Alt FW(1989) Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu Rev Genet 23:630–636

    Google Scholar 

  • Boyd RL, Hugo P(1991) Towards an integrated view of thymopoiesis. Immunol Today 12:71–79

    PubMed  CAS  Google Scholar 

  • Boyd RL, Tucek CL, Godfrey DI, Izon DJ, Wilson TJ, Davidson NJ, Bean AGD, Ladyman HM, Ritter MA, Hugo P(1993) The thymic microenvironment. Immunol Today 14:445–454

    PubMed  CAS  Google Scholar 

  • Brambell FWR(1966) The transmission of passive immunity from mother to young and the catabolism of immunoglobulins. Lancet ii:1087–1093

    Google Scholar 

  • Brambell FWR(1970) The transmission of passive immunity from mother to young. North Holland, Amstardam(Frontiers of biology, vol 18 )

    Google Scholar 

  • Brenner MB, McLean J, Dialynas DP, Strominger JL, SMith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS(1986) Identification of a putative second T-cell receptor. Nature 322:145–148

    PubMed  CAS  Google Scholar 

  • Brodsky FM, Guagliardi LE(1991) The cell biology of antigen processing and presentation. Annu Rev Immunol 9:707–744

    PubMed  CAS  Google Scholar 

  • Brown JH, Jardetzky TS, Gorga JC, Stern LJ, Urban RG, Strominger JL, Wiley DC(1993) The three- dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 364:33–39

    PubMed  CAS  Google Scholar 

  • Burmeister WP, Gastinel LN, Simister NE, Blum ML, Bjorkman PJ(1994) Crystal structure of 2.2 A resolution of the MHC-related neonatal Fc receptor. Nature 372:336–343

    PubMed  CAS  Google Scholar 

  • Burnet FM(1962) The role of the thymus and related organs in immunity. Br Med J 2:807–811

    PubMed  CAS  Google Scholar 

  • Burnet FM, Fenner F(1949) The production of antibodies, 2nd edn. Macmillan, London

    Google Scholar 

  • Butler JL, Suzuki T, Kubagawa H, Cooper MD(1987) Humoral immunity in the human neonate. In:Burgio GR, Hanson LA, Ugazio AG(eds) The immunology of the neonate. Springer, Berlin Hei¬delberg New York, pp 27–36

    Google Scholar 

  • Ceppellini R, Bonnard GD, Coppu F, Miggiano VC, Pospisil M, Curtoni ES, Pellegrino M(1971) Mixed leukocyte cultures and HL-A antigens. I. Reactivity of young foetuses, newborns and mothers at delivery. Transplant Proc 3:58–71

    PubMed  CAS  Google Scholar 

  • Chan AC, van Oers NSC, Trans A, Turka L, Law C-L, Ryan JC, Clark EA, Weiss A(1994) Differential expression of ZAP-70 and sky protein tyrosine kinases and the role of this family of protein and tyrosine kinases in TCR signalling. J Immunol 152:4758–4765

    PubMed  CAS  Google Scholar 

  • Chien J-H, Jores R(1995) T cells with B-cell-like recognition properties. Curr Biol 5:1116–1118

    Google Scholar 

  • Chien J-H, Jores R(1995) T cells with B-cell-like recognition properties. Curr Biol 5:1116–1118

    PubMed  CAS  Google Scholar 

  • Chien Y, Davis MM(1993) How ap T-cell receptors “see” peptide/MHC complexes. Immunol Today 14:597–601

    PubMed  CAS  Google Scholar 

  • Clark EA, Ledbetter JA(1994) How B and T cells talk to each other. Nature 367:425–128

    PubMed  CAS  Google Scholar 

  • Clevers H, Alarcon B, Wileman T, Terhorst C(1988) The T cell receptor/CD3 complex:a dynamic protein ensemble. Annu Rev Immunol 6:629–662

    PubMed  CAS  Google Scholar 

  • Clevers HC, Owen MJ(1991) Towards a molecular understanding of T-cell differentiation. Immunol Today 12:86–91

    PubMed  CAS  Google Scholar 

  • Clevers HC, Oosterwegel MA, Georgopoulos K(1993) Transcription factors in early T-cell development. Immunol Today 14:591–596

    PubMed  CAS  Google Scholar 

  • Colten HR(1973) Biosynthesis of the fifth component of complement(C5) by human fetal tissues. Clin Immunol Immunopathol 1:346–352

    PubMed  CAS  Google Scholar 

  • Colten HR(1976) Biosynthesis of complement. Adv Immunol 22:67–118

    PubMed  CAS  Google Scholar 

  • Conley ME(1994) X-linked immunodeficiencies. Curr Opin Genet Dev 4:401–06

    PubMed  CAS  Google Scholar 

  • Cooper NR, Moore MD, Nemerow GR(1988) Immunology of CR2, the lymphocyte receptor for Ep-95 stein-Barr virus and the C3d complement fragment. Annu Rev Immunol 6:85–113

    PubMed  CAS  Google Scholar 

  • Cowan JM, Ammann AJ, Wara DW, Howie VM, Schultz L, Doyle N, Kaplan M(1978) Pneumococcal polysaccharide immunization in infants and children. Pediatrics 62:721–727

    PubMed  CAS  Google Scholar 

  • Crabtree GR(1989) Contingent genetic regulatory events in T lymphocyte activation. Science 243:355–360

    PubMed  CAS  Google Scholar 

  • Crome P, Moffatt B, Adinolfi M(1971) HLA-antigens in human foetuses. In:Peeters H(ed) Protides of the biological fluids.Proceedings of the 18th colloquium, Bruges, 1970. Pergamon, New York, pp 55–61

    Google Scholar 

  • De Muralt G(1962) La maturation des immuno-globulines chez 1’homme. Vox Sang 7:513–525

    Google Scholar 

  • Desiderio SV(1993) Organization and assembly of immunoglobulin genes. In:Cooper EL, Nisbet-Brown E(eds) Developmental immunology. Oxford University Press, Oxford, pp 129–152

    Google Scholar 

  • Dobson NJ, Lambris JD, Ross GD(1981) Characteristics of isolated erythrocyte complement receptor type one(CR1, C4b-C3b receptor) and CR1 specific antibodies. J Immunol 126:693–698

    PubMed  CAS  Google Scholar 

  • du Pan RM, Wenger P, Koechli S, Scheidegger JJ, Roux T(1959) Etude de passage de la γ-globuline marquee a travers le placenta humain. Clin Chim Acta 4:110–115

    Google Scholar 

  • Eddy EM, Clark JM, Gong D, Fenderson BA(1981) Origin and migration of primordial germ cells in mammals. Gamete Res 4:333–362

    Google Scholar 

  • Epstein WV(1965) Specificity of macroglobulin antibody synthesised by the normal human fetus. Science 148:1591–1592

    PubMed  CAS  Google Scholar 

  • Fearon DT, Wong WW(1983) Complement ligand-receptor interactions that madiate biological responses. Annu Rev Immunol 1:243–271

    PubMed  CAS  Google Scholar 

  • Fedra VJ(1962) Placental transfer of antibodies in man. Am J Obstet Gynecol 84:1756–1760

    Google Scholar 

  • Fireman P, Zuchowski DA, Taylor PM(1969) Development of human complement system. J Immunol 103:25–31

    PubMed  CAS  Google Scholar 

  • Fishel CW, Pearlman DS(1961) Complement components of paired mother-cord sera. Proc Soc Exp Biol Med 107:695–699

    PubMed  CAS  Google Scholar 

  • Fowlkes BJ, Pardoll DM(1989) Molecular and cellular events of T cell development. Adv Immunol 44:207–264

    PubMed  CAS  Google Scholar 

  • Gardner B, Adinolfi M(1968) Serological and physicochemical characteristics of antibodies against Listeria monocytogenes in normal human sera. Guys Hosp Rep 117:19–30

    PubMed  CAS  Google Scholar 

  • Gascoigne NRJ, Chien Y, Becker DM, Kavaler J, Davis MM(1984) Genomic organization and sequence of T-cell receptor β-chain constant and joining-region genes. Nature 310:387–391

    PubMed  CAS  Google Scholar 

  • Germain RN(1994) MHC-dependent antigen processing and peptide presentation:providing ligands for T lymphocyte activation. Cell 76:287–299

    PubMed  CAS  Google Scholar 

  • Germain RN, Margulies DH(1993) The biochemistry and cell biology of antigen processing and pre¬sentation. Annu Rev Immunol 11:403–50

    PubMed  CAS  Google Scholar 

  • Gitlin D(1974) Protein transport across the placenta and protein turnover between amniotic fluid, maternal and fetal circulations. In:Moghissi KS, Hatze ESE(eds) The placenta:biological and clinical aspects. Thomas, Springfield, pp 151–191

    Google Scholar 

  • Gitlin D, Kumate J, Urrusti J, Morlaes C(1964) The selectivity of the human placenta in the transfer of plasma proteins from mother to fetus. J Clin Invest 43:1938–1951

    PubMed  CAS  Google Scholar 

  • Glynn AA, Martin W, Adinolfi M(1970) Levels of lysozyme in human foetuses and newborns. Nature 225:77–78

    PubMed  CAS  Google Scholar 

  • Godfrey DI, Zlotnik A(1993) Control points in early T-cell development. Immunol Today 14:547–553 Goodnow CC, Adelstein S, Basten A(1990) The need for central and peripheral tolerance in the B cell repertoire. Science 248:1373–1379

    Google Scholar 

  • Goodnow CC, Brink R, Adams E(1991) Breakdown of selftolerance in anergic B lymphocytes. Nature 352:532–536

    PubMed  CAS  Google Scholar 

  • Griffiths-Chu S, Patterson JAK, Berger CL, Edelson RC, Chu AC(1984) Characterization of immature T cell subpopulations in neonatal blood. Blood 64:296–300

    PubMed  CAS  Google Scholar 

  • Groettrub M, Ungewiss K, Azogni O, Palacios R, Owen MY, Hayday AC, von Boehmes H(1993) A novel disulfide-linked heterodimer on pre-T-cells consists of the T cell receptor β chain and 33 kd glycoprotein. Cell 75:283–294

    Google Scholar 

  • Grubb R, Laurell AB(1956) Hereditary serological human serum groups. Acta Pathol Microbiol Scand 39:390–398

    PubMed  CAS  Google Scholar 

  • Hamet I, Erkeller-Tuksel F, Lydyard P, Deneys V, DeBruyere M(1992) Developmental and maturational changes in human blood lymphocyte populations. Immunol Today 13:215–218

    Google Scholar 

  • Hammar J A(1921) The new views as to the morphology of the thymus gland and their bearing on the problem of the function of the thymus. Endocrinology 5:543, 731

    Google Scholar 

  • Hammer JA(1936) Die normal-morphologische Thymus-forschung imletzten Vierteljahrhundert. Barth, Leipzig

    Google Scholar 

  • Hanson LA, Adlerberth I, Carlsson B, Dahlgren U, Jalil F, Khan SR, Zaman S, Larsson P, Mellander L, Sheikh AK, Soderstrom T, Wold AES(1987) The ontogeny of the immune response:the role of maternal factors. In:Burgio GR, Hanson LA, Ugazio AG(eds) The immunology of th neonate. Springer, Berlin Heidelberg New York, pp 51–58

    Google Scholar 

  • Harris DT, Schumacher MJ, Locascio J, Besencon FJ, Olson GB, DeLuca D, Shenker L, Bard J, Boyse EA(1982) Phenotypic and functional immaturity of human unbilical cord blood lymphocytes. Proc Natl Acad Sci USA 89:10006–10010

    Google Scholar 

  • Hasek M, Leugerova A, Vojtiskova M(1961) Mechanisms of immunological tolerance. Proceedings of the Prague Symposium, 8–10 Nov 1961. Academic, London

    Google Scholar 

  • Haynes BF(1984) The human thymic microenvironment. Adv Immunol 36:87–142

    PubMed  CAS  Google Scholar 

  • Haynes BF, Martin ME, Kay HH, Kurtzberg J(1988) Early events in human T cell ontogeny:phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues. J Exp Med 168:1061–1080

    PubMed  CAS  Google Scholar 

  • Haynes BF, Denning SM, Singer KH, Kurtzberg J(1989) Ontogeny of T-cell precursors:a model for the initial stages of human T-cell development. Immunol Today 10:87–91

    PubMed  CAS  Google Scholar 

  • Hemmings WA, Williams EW(1976) The attachment of IgG to cell components of the transporting membrances. In:Hemmings WA(ed) Materno foetal transmission of immunoglobulins. Clinical and experimental immunoreproduction, vol 2. Cambridge University Press, Cambridge, pp 91–111

    Google Scholar 

  • Hill A, Ploegh H(1995) Getting the inside out:the transporter associated with antigen processing(TAP) and the presentation of viral antigen. Proc Natl Acad Sci USA 92:341–343

    PubMed  CAS  Google Scholar 

  • Hitzig WH(1959) Uber die transplacentare Ubertragung von Antikorper. Schweiz Med Wochenschr 89:1249–53

    PubMed  CAS  Google Scholar 

  • Hofman FM, Danilovs JA, Taylor CB(1984) HLA-DR(Ia)-positive dendritic-like cells in human fetal nonlymphoid tissues Transplantation 37:590–594

    CAS  Google Scholar 

  • Honjo T(1993) Immunoglobulin genes. Annu Rev Immunol 1:499–528

    Google Scholar 

  • Hood L, Kronenberg M, Hunkapiller T(1985) T cell antigen receptors and the immunoglobulin supergene family. Cell 40:225–229

    PubMed  CAS  Google Scholar 

  • Hugo P, Kappler JW, Marrack PC(1993) Positive selection of TCR αβ thymocytes:is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? Immunol Rev 135:133 –155

    Google Scholar 

  • Hyde RR(1932) The complement deficient guinea pig:a study of an inheritable factor in immunity. Am J Hyg 15:824–836

    Google Scholar 

  • Ito K, Bonneville M, Takagaki Y, Nekanishi N, Kanagawa O, Kucko EG, Tonegawa S(1989) Different T-cell receptors are expressed on thymocytes at different stages of development. Proc Natl Acad Sci USA 86. 631–635

    PubMed  CAS  Google Scholar 

  • Janeway CA(1992) The T cell receptor as a multicomponent signalling machine:CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol 10:645–674

    PubMed  CAS  Google Scholar 

  • Janeway CA, Bottomly K(1994) Signals and signs for lymphocyte responses. Cell 76:275–285

    PubMed  CAS  Google Scholar 

  • Jenkinson EJ, Billington WD, Elson J(1976) Detection of receptors for immunoglobulin on human placenta by EA rosette formation. Clin Exp Immunol 23:456–161

    PubMed  CAS  Google Scholar 

  • Jorgensen JL, Reay PA, Ehrich EW, Davis MM(1992) Molecular components of T cell recognition. Annu Rev Immunol 10:835–873

    PubMed  CAS  Google Scholar 

  • Kansas GS, Dailey MO(1989) Expression of adhesion structures during B-cell development in man. J Immunol 142:3058–3062

    PubMed  CAS  Google Scholar 

  • Kaufman J(1993) Ontogeny and phylogeny of MHC molecules. In:Cooper EL, Nisbet-Brown E(eds) Developmental immunology. Oxford University Press, Oxford, pp 53–84

    Google Scholar 

  • Kearse KP, Roberts JD, Wiest CL, Singer A(1995) Developmental regulation of ap T cell antigen receptor assembly in immature CD4 + CD8+ thymocytes. Bioessays 17:1049–1054

    PubMed  CAS  Google Scholar 

  • Kincade PW(1993) Cell adhesion mechanisms utilized for lymphoporesis. In:Shimizu(ed) Lymphocyte adhesion molecuses. Texas:Landes, Austin, pp 249–279

    Google Scholar 

  • Klein J(ed)(1986) Natural history of the major histocompatibility complex. Wiley, New York

    Google Scholar 

  • Klockars M, Reitamo S, Adinolfi M(1977) Ontogeny of human lysozyme. Distribution in fetal tissues. Biol Neonate 37:243 –249

    Google Scholar 

  • Kronenberg M, Brines R(1993) Developmental control of T cell antigen receptor gene rearrangement and expression. In:Cooper EL, Nisbet-Brown E(eds) Developmental immunology. Oxford university Press, Oxford, pp 153–173

    Google Scholar 

  • Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamkl SS, Sobel RA, Weiner HL, Kobari N, Glimcher LH(1995) B7-1 and B7-2 costimulatory molecules activate differentially the Thl/Th2 developmental pathways:application to autoimmune disease therapy. Cell 80:707–718

    PubMed  CAS  Google Scholar 

  • Kudo A, Melchers F(1987) A second gene, Vpre-B in the γ5 locus of the mouse which appears to be selectivley expressed in pre-B lymphocytes. EMBO J 6:2267–2272

    CAS  Google Scholar 

  • Lanier LL, Le AM, Cirin CI, Loken MR, Phillips JH(1986) The relationship of CD16(Leu-ii) and Leu- 19(NHK-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 136:4480–4485

    PubMed  CAS  Google Scholar 

  • Lanzavecchia A(1985) Antigen-specific interaction between T and B cells. Nature 314:537–539

    PubMed  CAS  Google Scholar 

  • Lanzavecchia A(1988) Clonal sketches of the immune response. EMBO J 7:2945–2951

    CAS  Google Scholar 

  • Lassila O(1981) Embryonic differentiation of lymphoid stem cells. Dev Comp Immunol 5:403–414

    PubMed  CAS  Google Scholar 

  • Lawler SD, Ukaljiofa EO, Reeves BR(1975) Interaction of maternal and neonates cells in mixed lym¬phocyte culture. Lancet ii:1185–1187

    Google Scholar 

  • Lederberg J(1959) Genes and antibodies:do antigens bear instructions for antibody specificity or do they select cell lines that arise by mutation? Science 129:1649–1653

    PubMed  CAS  Google Scholar 

  • LeDouarin NM, Jotereau FV(1975) Tracing of cells of the avain thymus through embryonic life in interspecific chimeras. J Exp Med 142:17–40

    PubMed  Google Scholar 

  • Lee CYG, Hwang LY, Beesly RP, Chen SH, Lee TY(1983) Immunogenicity of hepatitis B virus vaccine in healthy Chinese infants. J Infect Dis 148:526–529

    PubMed  CAS  Google Scholar 

  • Levinson AI, Dalai NF, Haidar M, Tar L, Orlow M(1987) Prominent IgM rheumatoid factor production by human cord blood lymphocytes stimulated in vitro with Staphyloccus aureus cowan I. J Immunol 139:2237–2241

    PubMed  CAS  Google Scholar 

  • Lewis SM(1994) The mechanisms of V(D)J rejoining:lessons from molecular, immunological, and comparative analysis. Adv Immunol 56:27–149

    PubMed  CAS  Google Scholar 

  • Lieber MR(1992) The mechanism of V(D)J recombination:a balance of diversity, specificity, and stabihty. Cell 70:873–876

    PubMed  CAS  Google Scholar 

  • Lin W-C, Desiderio S(1993) Regulations of V(D)J recombination activator protein RAG-2 by phos¬phorylation. Science 260:953–959

    PubMed  CAS  Google Scholar 

  • Linnet-Jepsen P, Galatius-Jensen F, Hauge M(1958) On the inheritance of Gm serum group. Acta Genet 8:164–196

    PubMed  CAS  Google Scholar 

  • Lo D, Sprent J(1986) Identity of cells that imprint H-2 restricted T cell specificity in the thymus. Nature 319:672–675

    PubMed  CAS  Google Scholar 

  • Lydyard PM, Quartey-Papafio R, Broker B, MacKenzie L, Jonquan J, Blaschek MA, Steele J, Petrou M, Collins P, Isenberg D, Youinou PY(1990) The antibody repertorire in early human B cells. Scand J Immunol 31:33–43

    PubMed  CAS  Google Scholar 

  • Maccario R, Burgio GR(1987) T and NK lymphocyte subpopulations in the neonate. In:Burgio GR, Hanson LA, Ugazio AG(eds) The immunology of the neonate. Springer, Berlin Heidelberg New York, pp 120–129

    Google Scholar 

  • Marrack P, Kappler J(1987) The T cell receptor. Science 238:1073–1087

    PubMed  CAS  Google Scholar 

  • Marrack P, Kappler JW(1983) How the immune system recognizes the body. Science 222:49–55

    Google Scholar 

  • Marx J(1995) The T cell receptor begins to reveal its many facets. Science 267:459–460

    PubMed  CAS  Google Scholar 

  • Matre R, Tonder O, Endresen C(1975) Fc receptors in human placenta. Scand J Immunol 4:741–745

    PubMed  CAS  Google Scholar 

  • McCracken GHy Shinefield HR(1965) Immunoglobulin concentrations in newborn infants with congenital cytomegalic inclusion disease. Pediatrics 36:933–937

    Google Scholar 

  • McVay LD, Carding SR, Bottomly K, Haydoy AC(1991) Regulated expression and structure of T cell Receptor γ/δ transcripts in human thymic ontogeny. EMBO J 1:83–91

    Google Scholar 

  • Medivinsky A, Dzierzak E(1996) Definitive haematopoiesis is autonomously initiated by the AMG region. Cell 86:897–906

    Google Scholar 

  • Miceli MC, Parnes JR(1993) Role of CD4 and CD8 in T cell activation and differentiation. Adv Immunol 53:59–122

    PubMed  CAS  Google Scholar 

  • Miller JFAP(1961a) Analysis of the thymus influence in leukaemogenesis. Nature 191:248–249

    CAS  Google Scholar 

  • Miller JFAP(1961b) Immunological function of the thymus. Lancet ii:748–749

    Google Scholar 

  • Miller JFAP(1994) The thymus:maestro of the immune system. Bioessays 16:509–513

    PubMed  CAS  Google Scholar 

  • Miller JFAP, Morahan G(1992) Peripheral T cell tolerance. Anna Rev Immunol 10:51–70

    CAS  Google Scholar 

  • Miyakawa Y, Yamada A, Kosaka K, Tsuda F, Mayumi M(1981) Defective immune-adhernce(C3b) receptor on erythrocytes from patients with systemic lupus erythematosus. Lancet ii:494–497

    Google Scholar 

  • Möller G(1988) Do suppressor T cells exist? Scand J Immunol 27:247–250

    PubMed  Google Scholar 

  • Mollison PL(1951) Blood transfusion in clinical medicine. Blackwell, Oxford

    Google Scholar 

  • Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaiannou VE(1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869–877

    PubMed  CAS  Google Scholar 

  • Moore MAS, Metcalf D(1970) Ontogeny of the haemopoietic system:yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo. Br J Haematol 18:279–296

    PubMed  CAS  Google Scholar 

  • Moore MAS, Owen JJT(1967) Experimental studies on the development of the thymus. J Exp Med 126:715–726

    PubMed  CAS  Google Scholar 

  • Mossman TR, Cottman RL(1989) Th 1 and Th 2 cells:different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173

    Google Scholar 

  • Müller-Eberhard HJ(1975) The complement system. In:Putnam FW(ed) The plasma proteins, vol 1. Academic, New York, pp 394–432

    Google Scholar 

  • Miiller-Eberhard HJ(1986) The membrane attack complex of complement. Annu Rev Immunol 4:503–528

    Google Scholar 

  • Murgita RA, Tomasi TB(1975a) Suppression of the immune response by a-fetoprotein. I. The effect of mouse a-fetoprotein on the primary and secondary antibody responses. J Exp Med 141:269–286

    CAS  Google Scholar 

  • Murgita RA, Tomasi TB(1975b) Suppression of the immune response by a-fetoprotein. II. The effect of mouse a-fetoprotein on mixed lymphocyte activity and mitogen-induced lymphocyte transformation. J Exp Med 141:440–452

    CAS  Google Scholar 

  • Nikolic-Zugic J, Bevan M(1990) Role of Self-peptides in positively selecting the T cell repertoire. Nature 344:65–67

    PubMed  CAS  Google Scholar 

  • Nossal GJV(1983) Cellular mechanisms of immunological tolerance. Annu Rev Immunol 1:33–62

    PubMed  CAS  Google Scholar 

  • Nossal GJV(1994) Negative selection of lymphocytes. Cell 76:229–239

    PubMed  CAS  Google Scholar 

  • Nossal GJV, Pike BL(1980) Clonal anergy:persistence in tolerance mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen. Proc Natl Acad Sci USA 77:1602–1608

    PubMed  CAS  Google Scholar 

  • Oettinger MA(1992) Activation of V(D)J recombination by RAG1 and RAG2. TIG 8:413–416

    PubMed  CAS  Google Scholar 

  • Oettinger MA, Schatz DG, Gorka C, Baltimore D(1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517–1523

    PubMed  CAS  Google Scholar 

  • Olding LB, Oldstone MBA(1976) Thymus-derived peripheral lymphocytes from human newborns inhibit division of their mother’s lymphocytes. J Immunol 116:682–686

    PubMed  CAS  Google Scholar 

  • Olding LB, Bernishke K, Oldstone MBA(1974) Inhibition of mitosis of lymphocytes from human adults by lymphocytes from human newborns. Clin Immunol Immunopathol 3:79–84

    PubMed  CAS  Google Scholar 

  • Osier AG, Sandberg AL(1973) Alternate complement pathways. Prog Allergy 17:51–92

    Google Scholar 

  • Owen JJT, Jenkinson EJ(1981) Embryology of the lymphoid system. Prog Allergy 29:1–34

    PubMed  CAS  Google Scholar 

  • Owen MJ(1993) T-cell differentiation under control. Curr Biol 3:780–782

    PubMed  CAS  Google Scholar 

  • Owen MJ, Crumpton MJ(1987) The role of class I and II antigens in T cell recognition. Br Med Bull 43:228–240

    PubMed  CAS  Google Scholar 

  • Owen RD(1945) Immunological consequences of vascular anastomoses between bovine twins. Science 102:400–401

    PubMed  CAS  Google Scholar 

  • Parker DC(1993) T cell-dependent B-cell activation. Annu Rev Immunol 11:331–360

    PubMed  CAS  Google Scholar 

  • Paul WE, Seder RA(1994) Lymphocyte responses and cytokines. Cell 76:241–251

    PubMed  CAS  Google Scholar 

  • Phillips JH, Hori T, Nagler A, Bhat N, Spits H, Lanier LL(1992) Ontogeny of human natural killer(NK) cells:fetal NK cells mediate cytolytic function and express cytoplasmic CD3E, s8 proteins. J Exp Med 175:1055 –1066

    Google Scholar 

  • Porcile V(1904) Untersuchungen liber der Herkunft der Plasmazellen in der Leber. Beitr Pathol Anat 36:375–381

    Google Scholar 

  • Propp RP, Alper CA(1968) C3 synthesis in the human fetus and lack of transplacental passage. Science 162:672–673

    PubMed  CAS  Google Scholar 

  • Pullen AM, Marrack P, Kappler JW(1988) The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 355:796–801

    Google Scholar 

  • Pund ER, Von Haam E(1957) Spirochetal and venereal disease. In Anderson WAD(ed) Pathology. Mosby, St Louis, pp 264–266

    Google Scholar 

  • Racadot E(1993) Cord-blood lymphocyte population. Immunol Today 14:189–190

    PubMed  CAS  Google Scholar 

  • Rammensee H-G, Falk K, Rotzschke O(1993) Peptides naturally presented by MHC class I molecules. Annu Rev Immunol 11:213–244

    PubMed  CAS  Google Scholar 

  • Raulet DH, Garman RD, Saito H, Tonegawa S(1985) Developmental regulation of T-cell receptor gene expression. Nature 314:103–107

    PubMed  CAS  Google Scholar 

  • Ravetch JV, Kinet J-P(1991) Fc receptors. Annu Rev Immunol 9:457–492

    CAS  Google Scholar 

  • Ravetch JV, Margulies DH(1994) New tricks for old molecules. Nature 372:323–324

    PubMed  CAS  Google Scholar 

  • Reichlin S(1993) Neuroendocrine-immune interactions. N Engl J Med 329:1246–1253

    PubMed  CAS  Google Scholar 

  • Remington JS, Miller MJ(1966) 19S and 7S antitoxoplasma antibodies in the diagnosis of acute congenital and acquired toxoplasmosis. Proc Soc Exp Biol 121:357–363

    Google Scholar 

  • Ritter MA, Boyd RL(1993) Development in the thymus:it takes two to tango. Immunol Today 14:462–469

    PubMed  CAS  Google Scholar 

  • Rocha B, Vassalli P, Guy-Grand D(1992) The extrathymic T-cell development pathway. Immunol Today 13:449–453

    PubMed  CAS  Google Scholar 

  • Rolink A, Melchers F(1991) Molecular and cellular origins of B lymphocyte diversity. Cell 66:1081–1094 Romagnani S(1989) Cytokines involved in activation, growth and differentiation of human B cells. J Immunol

    Google Scholar 

  • Res 1:41–51

    Google Scholar 

  • Romagnani S, Del Prete GF, Maggi E, Falagiani P, Ricci M(1980) T-cell independence of immunoglobulin synthesis by human peripheral blood lymphocytes stimulated with SpA-containing staphylococci. Immunology 41:921–927

    PubMed  CAS  Google Scholar 

  • Rosen FS, Cooper MD, Wedgwood RIP(1995) The primary immunodeficiencies. N Engl J Med 7:431–440

    Google Scholar 

  • Rosenthal P, Rimm I J, Umiel T, Griffin JD, Osathanondh R, Schlossman SF, Nadler LM(1983) On¬togeny of human hematopoietic cells:analysis utilizing monoclonal antibodies. J Immunol 131:323–327

    Google Scholar 

  • Ross GD, Atkinson JP(1985) Complement receptor structure and function. Immunol Today 6:115–119

    CAS  Google Scholar 

  • Roth PE, DeFranco AL(1995) Intrinsic checkpoints for lineage progression. Curr Biol 5:349–352

    PubMed  CAS  Google Scholar 

  • Rother K, Rother U(1986) Biological functions of the complement system. Prog Allergy 39:24–100

    PubMed  CAS  Google Scholar 

  • Ruiz P, Schwarzler C, Gunthert U(1995) CD44 isoforms during differentiation and development. Bio- essays 17:17–24

    CAS  Google Scholar 

  • Ruuskanen O, Pittard WB, Miller K, Pierce G, Sorensen RU, Polmar SH(1980) Staphylococcus aureus cowan I-induced immunoglobulin production in human cord blood lymphocytes. J Immunol 125:411–413

    PubMed  CAS  Google Scholar 

  • Sakaguchi N, Melchers F(1986) ?5, a new light chain-related locus selectively expressed in pre-B lymphocytes. Nature 324:579–582

    Google Scholar 

  • Sansoremo W(1995) A review of the mechanisms of oral tolerance and immunotheraphy. J R Soc Med 88:14–17

    Google Scholar 

  • Sawyer MK, Forman MJ, Kuplic L, Stiehm ER(1971) Developmental aspects of the human complement system. Biol Neonate 19:148–162

    PubMed  CAS  Google Scholar 

  • Schwartz RH(1985) T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 3:237–261

    PubMed  CAS  Google Scholar 

  • Schwartz RH(1989) Acquisition of immunological self-tolerance. Cell 57:1073–1081

    PubMed  CAS  Google Scholar 

  • Shimuzu A, Honjo T(1984) Immunoglobulin class switching. Cell 36:801–803

    Google Scholar 

  • Shinkai Y, Rathbun G, Lam K-P, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM, Alt FW(1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements. Cell 68:855–867

    PubMed  CAS  Google Scholar 

  • Silverstein AM(1964) Ontogeny of immune response. Science 144:1423–1425

    PubMed  CAS  Google Scholar 

  • Silverstein AM, Lukes RJ(1962) Fetal response to antigenic stimulus. I. Plasma-cellular and lymphoid reactions in human fetus to intrauterine infection. Lab Invest 11:918–932

    PubMed  CAS  Google Scholar 

  • Smith RT, Eitzman DV, Catlin MC, Wirtz OE, Miller BE(1964) The development of the immune response. Characterization of the response of the human infant and adult to immunization with Salmonella vaccines. Pediatrics 68:163–183

    Google Scholar 

  • Smith LG, Weissman IL, Heimfeld S(1991) Clonal analysis of haemotopoietic stem cell differentiation in vivo. Proc Natl Acad Sci USA 88:2788–2792

    PubMed  CAS  Google Scholar 

  • Soothill JF, Hayes K, Dudgeon JA(1966) The immunoglobulins in congenital rubella. Lancet i:1385–1386

    Google Scholar 

  • Sottzup-Jensen L, Stepanik TM, Kristensen T et al(1985) Common evolutionary origin of a2-macro-globulin and complement C3 and C4. Proc Natl Acad Sci USA 82:9–13

    Google Scholar 

  • Sprent J(1995) Professional and amateurs. Curr Biol 5:1095–1097

    PubMed  CAS  Google Scholar 

  • Sprent J, Loh D, Gao EK, Rpn Y(1988) T cell selection in the thymus. Immunol Rev 101:173–190

    PubMed  CAS  Google Scholar 

  • Sprent J, Gao E-K, Webb SR(1990) T cell reactivity to MHC molecules:immunity versus tolerance. Science 248:1357–1363

    PubMed  CAS  Google Scholar 

  • Steinman RM(1991) The dendritic cell system and its role in immunogenecity. Annu Rev Immunol 9:271–296

    PubMed  CAS  Google Scholar 

  • Stiehm ER, Amnann AJ, Cherry JD(1966) Elevated cord macroglobulins in the diagnosis of intrauterine infections. N Engl J Med 275:971–977

    PubMed  CAS  Google Scholar 

  • Sties DP, Fudenberg HH(1974) Ontogeny of cellular immunity in the human fetus. Development of responses ot phytohemagglutinin and to allogeneic cells. Cell Immunol 11:257–271

    Google Scholar 

  • Story CM, Mikulska JE, Simister NE(1994) A major histocompatibility complex class I-like Fc receptor cloned from human placenta:possible role in transfer of immunoglobulin G from mother to fetus. J Exp Med 180:2377–2381

    PubMed  CAS  Google Scholar 

  • Strachan T(1987) Molecular genetics and polymorphism of class I HLA antigens. Br Med Bull 43:1–14

    PubMed  CAS  Google Scholar 

  • Strominger JL(1987) Structure of class I and class II HLA antigens. Br Med Bull 43:81–93

    PubMed  CAS  Google Scholar 

  • Stutman O(1985) Ontogeny of T cells. Clin Immunol Allergy 5:191–234

    Google Scholar 

  • Stutman O(1987) T-cell development. In:Burgio GR, Hason LA, Ugazio AG(eds) The immunology of the neonate. Springer, Berlin Heidelberg New York, pp 5–26

    Google Scholar 

  • Swain SL(1995) who does the polarizing? Curr Biol 5:849–851

    Google Scholar 

  • Talmage DW(1969) The nature of the immunological response. In:Adinolfi M(ed) Immunology and development. Spastics International Medical Publications, London, pp 1–26

    Google Scholar 

  • Tedder TF, Fearon DT, Garland GL, Cooper MD(1983) Expression of C3b receptors on human B cells and myelomonocytic cells but not natural killer cells. J Immunol 130:1688–1673

    Google Scholar 

  • Teh H-S, Kisielow P, Scott B, Kishi H, Uematsu Y, Blutmann H, von Boehmer H(1988) Thymic MHC antigens and the mocp T cell receptor determine the CD4/CD8 phenotype of T cells. Nature 335:229–233

    PubMed  CAS  Google Scholar 

  • Tenner AJ, Cooper NR(1981) Identification of types of cells in human peripheral blood that blind Clq. J Immunol 126:1174–1179

    PubMed  CAS  Google Scholar 

  • Thorbecke GJ, Hochwald GM, van Furth R, Miiller-Eberhard HJ, Jacobsent ER(1965) Problems in determining the sites of synthesis of complement reactions. Ciba Found Symp, pp 99 - 114

    Google Scholar 

  • Toivanen P, Uksila J, Leino A, Lassila O, Hirvonen T, Ruuskanen O(1981) Development of mitogen responding T cells and natural killer cells in the human fetus. Immunol Rev 57:89–105

    PubMed  CAS  Google Scholar 

  • Tonegawa S(1983) Somatic generation of antibody diversity. Nature 302:575–581

    PubMed  CAS  Google Scholar 

  • Tonegawa S, Berns A, Bonneville M, Farr A, Ishida I, Ito K, Itohara S, Janeway CA, Kanagawa O, Katsuki M, Kubo R, Lafaille J, Mombaerts P, Murphy D, Nakanishi N, Takagaki Y, Van Kaer L, Berbeek S(1989) Diversity, development, ligands, and probable functions of y5 T cells. Cold Spring Harb Symp Quant Biol LIV:31–44

    Google Scholar 

  • Townsend A, Bodmer H(1989) Antigen recognition by class I restricted T lymphocytes. Annu Rev Immunol 7:601–624

    PubMed  CAS  Google Scholar 

  • Townsend AR, Gotch FM, Davey J(1985) Cytotoxic T cells recognize fragments of the influenza nu- cleoprotein. Cell 42:457–467

    PubMed  CAS  Google Scholar 

  • Traub M(1943) The complement activity of the serum of healthy persons, mothers and newborn infants. J Pathol Bacterial 55:447–452

    Google Scholar 

  • Travers P(1990) One hand clapping. Nature 348:393–394

    PubMed  CAS  Google Scholar 

  • Travers P(1993) Immunological agnosia. Nature 363:117–118

    PubMed  CAS  Google Scholar 

  • Trevorrow VE(1959) Concentration of gamma-globulin in the serum of infants during the first 3 months of life. Paediatrics 24:746–751

    CAS  Google Scholar 

  • Trinchieri G(1989) Biology of natural killer cells. Adv Immunol 47:187–376

    PubMed  CAS  Google Scholar 

  • Trowsdale J(1987) Genetics and polymorphism:class II antigens. Br Med Bull 43:15–36

    PubMed  CAS  Google Scholar 

  • Unanue ER(1984) Antigen-presenting function of the macrophage. Annu Rev Immunol 2:395–428

    PubMed  CAS  Google Scholar 

  • Vahlquist B(1958) The transfer of antibodies from mother to offspring. Adv Pediatr 10:305–325

    Google Scholar 

  • van Furth R, Schuit HRE, Hijmans W(1965) The immunological development of the human fetus. J Exp Med 122:1173–1188

    PubMed  Google Scholar 

  • von Boehmer H(1992) Thymic selection:a matter of life and death. Immunol Today 13:454–458

    Google Scholar 

  • von Boehmer H(1994) Positive selection of lymphocytes. Cell 76:219–228

    Google Scholar 

  • Wade WF, Davoust Y, Salemero J, André P, Watts TH, Combier J-C(1993) Structural compartmen- talisation of MHC class II signaling function. Immunol Today 14:539–546

    PubMed  CAS  Google Scholar 

  • Wasserman P, Alberts E(1940) Complement titre of blood of the newborn. Proc Soc Exp Biol Med 45:563–564

    CAS  Google Scholar 

  • Weiss A(1991) Molecular and genetic insights into T cell antigen receptor structure and function. Annu Rev Genet 25:487–510

    PubMed  CAS  Google Scholar 

  • Weiss A, Bogen B(1991) MHC class II-restricted presentation of interacellular antigen. Cell 64:767–776

    PubMed  CAS  Google Scholar 

  • Weiss A, Littman DR(1994) Signal transduction by lymphocyte antigen receptors. Cell 76:263–274

    PubMed  CAS  Google Scholar 

  • Weissman IL(1994) Developmental switches in the immune system. Cell 76:207–218

    PubMed  CAS  Google Scholar 

  • Wild AE(1973) Transport of immunoglobulins and other proteins from mother to young. In:Dingle JT(ed) Lysosomes in biology and pathology. University of Chicago press, Chicago, pp 495–514

    Google Scholar 

  • Wild AE(1975) Role of the cell surface in selection during transport of proteins from mother to foetus and newly born. Phil Trans R Soc Lond 271B:395–410

    Google Scholar 

  • Wild AE(1981) Endocytic mechanisms in protein transfer across the placenta. Placenta [Suppl] 1:165–186

    Google Scholar 

  • Williams AF, Barclay AN(1988) The immunoglobulin superfamily:domains for cell surface recognition. Annu Rev Immunol 6:381–405

    PubMed  CAS  Google Scholar 

  • Wilson JG, Wong WW, Schur PH, Fearon DT(1982) Mode of inheritance of decreased c3b receptors on erythrocytes of patients with systemic lupus erythematosus. N Engl J Med 307:981–986

    PubMed  CAS  Google Scholar 

  • Wu L, Kincade PW, Shortman K(1993) The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate. Immunol Lett 38:69–75

    PubMed  CAS  Google Scholar 

  • Ziegler K, Unanue ER(1981) Identification of a macrophage antigen-processing event required for I- region-restricted antigen presentation to T-lymphcytes. J Immunol 127:1869–1875

    PubMed  CAS  Google Scholar 

  • Zinkernagel RM, Doherty PC(1974) Restriction of; in vitro T cell medicated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semi-allogenic system. Nature 248:7012–702

    Google Scholar 

  • Zinkernagel RM, Callahan G, Althage A, Cooper S, Klein P, Klein J(1978) On the thymus in the differentiation of H-2 self-recognition by T cells:evidence for dual recognition. J Exp Med 147:882–896

    PubMed  CAS  Google Scholar 

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    M. Adinolfi

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    Lars B. Olding M.D., Ph.D.

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Adinolfi, M. (1997). Ontogeny of Human Natural and Acquired Immunity. In: Olding, L.B. (eds) Reproductive Immunology. Current Topics in Microbiology and Immunology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60614-4_4

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