Natural Antibody Polymorphism and Anti-Galα1–3Gal Antibodies

  • T. D. H. Cairns
  • J. Lee
  • L. C. Goldberg
  • B. E. Samuelsson
  • D. H. Taube

Abstract

The best characterized natural antibodies are anti-carbohydrate antibodies. Landsteiner described blood group A and B isoagglutinins in 1900 [1], but the original, earlier descriptions of natural antibodies were of heterophile agglutinins [2], some of which were cross-absorbable between species. Landsteiner [3] observed that species in which the target antigen of a heterophile agglutinin was absent would have naturally occurring agglutinins specific for that antigen, much as he had described individuals within a species as having A or B isoagglutinins whenever blood group A or B was absent. He regarded the presence of antigen within a species as following genera or families (although not exclusively), and the presence of heterophile agglutinin as doing likewise in a reciprocal fashion.

Keywords

Natural Antibody Rabbit Erythrocyte Terminal Linkage Natural Human Antibody Link Galactose Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • T. D. H. Cairns
  • J. Lee
  • L. C. Goldberg
  • B. E. Samuelsson
  • D. H. Taube

There are no affiliations available

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