Use of Transgenic Animals as Xenotransplant Donors

  • J. L. Platt
  • J. S. Logan


One factor which has contributed to a recent surge in interest in xenotransplantation is the development of transgenic animals for use as xenotransplant donors. The development of these animals not only reflects a certain measure of technical advance, it also results from a rapid expansion of basic knowledge about the molecular hurdles to the xenotransplantation of organs from lower mammals into humans [1]. This chapter will review some of the ways in which genetic engineering can address the immunologic hurdles to xenotransplantation and in doing so further extend basic knowledge.


Transgenic Animal Human CD59 Paroxysmal Nocturnal Hemoglobinuria Membrane Attack Complex Human Complement 
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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. L. Platt
  • J. S. Logan

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