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Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation

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Book cover Xenotransplantation

Abstract

Induction of donor-specific tolerance would be desirable and might even be essential to the success of clinical xenotransplantation for several reasons:

  1. 1.

    It would eliminate the risk of acute or chronic rejection. Chronic rejection currently leads to eventual graft loss in a high percentage of allograft recipients, despite recent improvements in immunosuppressive therapy. In view of the frequently greater difficulty that is encountered in attenuating xenoresponses than alloresponses [1], it seems likely that both acute and chronic rejection might be a major limitation to xenogeneic organ transplantation, even if the initial natural antibody-induced hyperacute rejection problem could be overcome.

  2. 2.

    A state of tolerance would obviate the need for chronic imunosuppressive therapy with its attendant risks of opportunistic infection, malignancy and organ toxicity.

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Authors
  1. M. Sykes
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  2. D. H. Sachs
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Editors and Affiliations

  1. Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 02129, Boston, Massachusetts, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  2. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  3. Department of Nephrology, Odense University Hospital, 5000, Odense, Denmark

    Ejvind Kemp M.D. (Professor and Head) (Professor and Head)

  4. Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Jeffrey L. Platt M.D. (Joseph W. and Dorothy W. Beard Professor) (Joseph W. and Dorothy W. Beard Professor)

  5. Department of Surgery, University of Cambridge, Cambridge, CB22QQ, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

  6. Imutran Laboratories, Cambridge, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

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Sykes, M., Sachs, D.H. (1997). Xenogeneic Tolerance Through Hematopoietic Cell and Thymic Transplantation. In: Cooper, D.K.C., Kemp, E., Platt, J.L., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60572-7_38

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  • DOI: https://doi.org/10.1007/978-3-642-60572-7_38

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