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Experimental Lung Xenografting

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Book cover Xenotransplantation

Abstract

Lung and heart-lung transplantation are now established as therapeutic interventions for many terminal conditions affecting the pulmonary system. Unfortunately, the growth in supply of donor lungs has lagged behind demand. Paradoxically, our increasing clinical success exacerbates the donor organ shortage by broadening indications for transplantation and increasing referrals of appropriate patients at an earlier stage in their disease. As a consequence, appropriate organs are often not available in time, and many of those accepted for transplant die waiting. One third of cystic fibrosis patients (181 of 544) listed between 1990 and 1994 died before transplantation; similar mortality occurs for patients with other underlying pathology [1]. The most acute need is among patients with congenital heart disease and those with cystic fibrosis, for both of whom a heart-lung bloc or double lung graft represents their best or only viable option, and patients with idiopathic pulmonary fibrosis, whose unpredictable, often fulminant course frequently results in mortality shortly after listing. Patients with these and other end-stage pulmonary disorders might benefit if xenogeneic lungs were available.

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Authors
  1. R. N. Pierson III
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  2. G. Pino-Chavez
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Editor information

Editors and Affiliations

  1. Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 02129, Boston, Massachusetts, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  2. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  3. Department of Nephrology, Odense University Hospital, 5000, Odense, Denmark

    Ejvind Kemp M.D. (Professor and Head) (Professor and Head)

  4. Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Jeffrey L. Platt M.D. (Joseph W. and Dorothy W. Beard Professor) (Joseph W. and Dorothy W. Beard Professor)

  5. Department of Surgery, University of Cambridge, Cambridge, CB22QQ, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

  6. Imutran Laboratories, Cambridge, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

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© 1997 Springer-Verlag Berlin Heidelberg

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Pierson, R.N., Pino-Chavez, G. (1997). Experimental Lung Xenografting. In: Cooper, D.K.C., Kemp, E., Platt, J.L., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60572-7_35

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  • DOI: https://doi.org/10.1007/978-3-642-60572-7_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64460-3

  • Online ISBN: 978-3-642-60572-7

  • eBook Packages: Springer Book Archive

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