Neutralization of the Cytotoxic Effect of Anti-αGal Antibodies with Monoclonal Anti-idiotypic Antibodies
The use of the pig (or other widely divergent species) as a donor of organs for humans is dependent upon the development of a successful method of overcoming the hyperacute rejection (as well as any subsequent immune response) that is mounted in humans against grafted pig organs. The initiating factor in this hyperacute rejection is believed to be the presence of preformed antibodies in the recipient’s serum [1–4]. Recipient xenoreactive antibodies bind target molecules on the vascular endothelial cell surface of the xenografted organ and activate complement, leading to endothelial cell destruction and resulting in interstitial hemorrhage and edema.
KeywordsPK15 Cell Hyperacute Rejection Xenograft Rejection Normal Human Donor Serum Cytotoxicity
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