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Removal of Natural Antibodies by Immunoadsorption: Results of Experimental Studies

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Xenotransplantation

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Abstract

The clinical application of xenotransplantation from swine into humans will likely require the use of effective and well-tolerated techniques for antibody removal. This assumption is based upon the growing body of scientific evidence which implicates xenoreactive antibody binding and activation of the comple ment cascade as central events in the process of hyperacute xenograft rejection [1, 2]. Although transgenic approaches are presently being employed to engineer porcine organs which are inherently resistant to human antibody-dependent, complement mediated damage (i.e., expression of human regulators of complement activation; αGal1–3Gal “knockout” swine), it is more than likely that removal of pre-existing xenoreactive antibodies will be necessary in the pretransplant period. In addition, it may be necessary to remove antibodies from the xenograft recipient after transplantation on a regular basis until a process of graft adaptation or accomodation takes place.

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Authors
  1. J. R. Leventhal
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Editors and Affiliations

  1. Immunologist (Surgery), Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, 02129, Boston, Massachusetts, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  2. Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA

    David K. C. Cooper M.A., M.D., Ph.D., M.S., F.R.C.S. (Associate Member, Scientific Staff) (Associate Member, Scientific Staff)

  3. Department of Nephrology, Odense University Hospital, 5000, Odense, Denmark

    Ejvind Kemp M.D. (Professor and Head) (Professor and Head)

  4. Departments of Surgery, Pediatrics and Immunology, Duke University Medical Center, Durham, NC, 27710, USA

    Jeffrey L. Platt M.D. (Joseph W. and Dorothy W. Beard Professor) (Joseph W. and Dorothy W. Beard Professor)

  5. Department of Surgery, University of Cambridge, Cambridge, CB22QQ, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

  6. Imutran Laboratories, Cambridge, UK

    David J. G. White M.A., Ph.D., M.R.C.Path (Immunologist and Lecturer, Director of Research and Development) (Immunologist and Lecturer, Director of Research and Development)

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© 1997 Springer-Verlag Berlin Heidelberg

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Leventhal, J.R. (1997). Removal of Natural Antibodies by Immunoadsorption: Results of Experimental Studies. In: Cooper, D.K.C., Kemp, E., Platt, J.L., White, D.J.G. (eds) Xenotransplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60572-7_26

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  • DOI: https://doi.org/10.1007/978-3-642-60572-7_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64460-3

  • Online ISBN: 978-3-642-60572-7

  • eBook Packages: Springer Book Archive

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