Hemostasis in Xenotransplantation

  • B. J. Hunt
  • K. M. Jurd

Abstract

The recent revival of interest in xenotransplantation across discordant species focused initially on immunological aspects of hyperacute rejection. More latterly, research has explored the effects of antibody and complement binding to the endothelial cell. However the ultimate end-point of hyperacute rejection (the xenograft reaction) can be considered to be microvascular thrombosis. Thus hemostasis, the complex system which maintains the fluidity of blood within a vessel, but forms a clot once the vessel wall is breached, is an obligatory component of the xenograft reaction. This chapter will cover a basic understanding of hemostasis and then discuss the relative importance of hemostatic activation in the pig-to-human xenograft reaction.

Keywords

Tissue Factor Heparan Sulphate Tissue Factor Pathway Inhibitor Endothelial Cell Activation Porcine Aortic Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • B. J. Hunt
  • K. M. Jurd

There are no affiliations available

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