Since the first edition of this book was published in 1991, the field of xenotransplantation has enjoyed a striking and gratifying rate of progress. This reflects in part the high level of enthusiasm among those in the field of transplantation for the idea that xenotransplantation may finally be approaching clinical application. This progress also reflects a change in the approach to inquiry in this field. The empirical approach, testing therapeutic agents singly or in combination for effects on graft survival, has been supplanted by attention to research design, focusing on the immunologic and other biological hurdles to xenotransplantation. Although this rapidly evolving field has not yet progressed to clinical reality, it would surprise none of us if this goal was soon achieved.
KeywordsCellular Immune Response Complement Regulatory Protein Hyperacute Rejection Xenograft Rejection Xenogeneic Cell
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