Skip to main content
SpringerLink
Log in

Deficiencies of the MHC Class I Antigen Processing and Presentation Machinery in Tumor Cells

  • Conference paper
Book cover Symposium in Immunology VI

  • 41 Accesses

Abstract

The major histocompatibility complex (MHC) class I genes, which are composed of a polymorphic heavy chain noncovalently linked with ß2-microglobulin (ß2-m; Bjorkman et al.1987), play a key role in numerous immunological processes involving the presentation of “foreign” antigens for recognition by the CD8-positive cytotoxic T lymphocytes (CTLs; Zinkernagel and Doherty 1979). This suggests that (1) cytotoxic T cells can monitor genetic changes and that (2) the MHC class I system provides an enormous diversity in potential antigenic peptide presentation including recognition of tumor cells by autologous CTL in man and animals (Boon et al. 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackrill AM, Blair GE (1988) Regulation of the major histocompatibility class I gene expression at the level of transcription in highly oncogenic adenovirus transformed rat cells. Oncogene 3: 483–487

    PubMed  CAS  Google Scholar 

  • Androlewicz MJ, Ortmann B, Van Endert PM, Spies T, Cresswell P (1993) Characteristics of peptide and major histocompatibility complex class-I J3-microglobulin binding to the transporters associated with antigen-processing (tapi and tape). Proc Natl Acad Sci USA 91: 12716–12720

    Article  Google Scholar 

  • Arnold DJ, Driscoll M, Androlewicz M, Hughes E, Cresswell P, Spies T (1992) Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature 360: 171–174

    Article  PubMed  CAS  Google Scholar 

  • Attaya M, Jameson S, Martinez E, Hermel E, Aldrich C, Forman J, Fischer-Lindahl K, Bevan MJ, Monaco JJ (1992) Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature 355: 647–649

    Article  PubMed  CAS  Google Scholar 

  • Barber L, Parham P (1994) The essence of epitopes. J Exp Med 180: 1191–1194

    Article  PubMed  CAS  Google Scholar 

  • Bennet M, Lawrence YY, Stoneman E, Rembecki RM, Mathew PA, Fisher-Lindahl K, Kumar V (1995) Hybrid resistance: “negative” and “positive” signaling of murine natural killer cells. Semin Immunol 7: 121–127

    Article  Google Scholar 

  • Bjorkman PJ, Saper MA, Saraoui B, Bennett WS, Strominger JL, Wiley DC (1987) Structure of the human MHC class I histocompatibility antigens. Nature 329: 512–518

    Article  PubMed  CAS  Google Scholar 

  • Blanchet O, Bourge J-F, Zinszner H, Israel A, Kourilsky P, Dausset J, Degos L, Paul P (1992) Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cells lacking class I antigen expression. Proc Natl Acad Sci USA 89: 3488–3492

    Article  PubMed  CAS  Google Scholar 

  • Boon T, Cerrottini JC, van den Eynde B, van der Bruggen P, van der Pel A (1994) Tumor antigens recognized by T-lymphocytes. Annu Rev Immunol 12: 337–365

    Article  PubMed  CAS  Google Scholar 

  • Brown MC, Driscoll J, Monaco JJ (1991) Structural and serological similarity of MHClinked LMP and proteasome (multicatalytic proteinase) complexes. Nature 353: 355–357

    Article  PubMed  CAS  Google Scholar 

  • Cerundolo V, Kelly A, Elliott T, Trowsdale J, Townsend A (1995) Genes encoded in the major histocompatibility complex affecting the generation of peptides for TAP transport. Eur J Immunol 25: 554–562

    Article  PubMed  CAS  Google Scholar 

  • Ciccone E, Pende D, Viale O, Di Donato C, Orengo AM, Biassoni R, Verdiani S, Amoroso A, Moretta A, Moretta L (1992) Involvement of HLA class I alleles in NK cell-specific function: expression of HLA-Cw3 confers selective protection from lysis by alloreactive clones displaying a defined specifity (specifity 2). J Exp Med 176: 963–971

    Article  PubMed  CAS  Google Scholar 

  • Cordon-Cardo C, Fuks Z, Drobnjak M, Moreno C, Eisenbach L, Feldman M (1991) Expression of HLA-A, B, C antigens on primary and metastatic tumor cell populations of human carcinomas. Cancer Res 51: 6372–6380

    PubMed  CAS  Google Scholar 

  • Cromme FV, Meijer CJLM, Snidjers PJF, Uyterlinde U, Kenemans P, Helmerhorst T, Stern PL, van der Brule AJC, Walboomers JJ (1993) Analysis of MHC class I and class II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions. Br J Cancer 67: 1372–1380

    Article  PubMed  CAS  Google Scholar 

  • Cromme FV, Airey J, Heemels MT, Ploegh H, Keating PJ, Stern PL, Meijer CJLM, Walboomers JMM (1994) Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. J Exp Med 179: 335–340

    Article  PubMed  CAS  Google Scholar 

  • Darrow TL, Slingluff CL, Siegler HF (1989) The role of HLA class I antigens in recognition of melanoma cells by tumor specific cytolytic T Iymphocytes. J Immunol 142: 3329–3335

    PubMed  CAS  Google Scholar 

  • Deverson EV, Gow IR, Coadwell WJ, Monaco JJ, Butcher GW, Howard JC (1990) MHC class II region encoding proteins are related to the multidrug resistance family of transmembrane transporters. Nature 348: 738–741

    Article  PubMed  CAS  Google Scholar 

  • Driscoll J, Brown MG, Finley D, Monaco JJ (1993) MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature 365: 262–264

    Article  PubMed  CAS  Google Scholar 

  • D’Urso CM, Wang ZG, Cao Y, Tatake R, Zeff RA, Ferrone S (1991) Lack of HLA class I antigen expression by cultured melanoma FO-1 cells due to a defect in 132.-m gene expression. J Clin Invest 87: 284–292

    Article  PubMed  Google Scholar 

  • Eager K, Williams J, Breiding D, Pans S, Knowles B, Appella E, Ricciardi RP (1985) Expression of histocompatibility antigens H-2K, -D, and -L is reduced in adenovirus 12 transformed mouse cells and is restored by IFN. Proc Natl Acad Sci USA 82: 5525–5529

    Article  PubMed  CAS  Google Scholar 

  • Deficiencies of the MHC Class I Antigen Processing and Presentation… 37

    Google Scholar 

  • Epperson DE, Arnold D, Spies T, Cresswell P, Pober JS, Johnson DR (1992) Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J Immunol 149: 3297–3301

    PubMed  CAS  Google Scholar 

  • Fehling HJ, Swat W, Laplace C, Kühn R, Rajewsky K, Müller U, von Böhmer H (1994) MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265: 1234–1237

    Article  PubMed  CAS  Google Scholar 

  • Ferrone S, Marincola FM (1995) Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol Today 16: 487–494

    Article  PubMed  CAS  Google Scholar 

  • Friedman DJ, Ricciardi RP (1988) Adenovirus type 12 E1A gene represses accumulation of MHC class I mRNAs at the level of transcription. Virol 165: 303–305

    Article  CAS  Google Scholar 

  • Früh K, Ahn K, Djaballah H, Sempé P, van Endert PM, Tampé R, Peterson PA, Yang Y (1995) A viral inhibitor of peptide transporters for antigen presentation. Nature 375 415–418

    Article  PubMed  Google Scholar 

  • Gaczynska M, Rock KL, Goldberg AL (1993) Interferon-gamma and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365: 264–267

    Article  PubMed  CAS  Google Scholar 

  • Garrido F, Cabrera T, Concha A, Glew S, Ruiz-Cabello F, Stern PL (1993) Natural history of HLA expression during tumour development. Immunol Today 14 491–499

    Article  PubMed  CAS  Google Scholar 

  • Glynne R, Powis SH, Beck S, Kelly A, Kerr LA, Trowsdale J (1991) A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC. Nature 353: 357–360

    Article  PubMed  CAS  Google Scholar 

  • Goldberg AL (1995) Functions of the proteasome: the lysis at the end of the tunnel. Science 268: 522–523

    Article  PubMed  CAS  Google Scholar 

  • Goldberg AL, Rock KL (1992) Proteolysis, proteasomes and antigen presentation. Nature 357 375–379

    Article  PubMed  CAS  Google Scholar 

  • Goodenow RS, Vogel JM, Linsk RL (1985) Histocompatibility antigens on murine tumors. Science 230: 777–783

    Article  PubMed  CAS  Google Scholar 

  • Gueguen M, Biddison WE, Long EO (1994) T-cell recognition of an HLA-A2 restric-ted epitope derived from a cleaved signal sequence. J Exp Med 180: 1989–1994

    Article  PubMed  CAS  Google Scholar 

  • Hämmerling GJ, Klar D, Pulm W, Momburg F, Moldenhauer G (1987) The influence of MHC class I antigens on tumor growth and metastasis. Biochim Biophys Acta 179: 245–259

    Google Scholar 

  • Heemels MT, Ploegh HL (1994) Substrate-specificity of allelic variants of the tap peptide transporter. Immunity 1: 775–784

    Article  PubMed  CAS  Google Scholar 

  • Henderson RA, Michel H, Sakaguchi K, Shabanowitz J, Appella E, Hunt DF, Engelhard VH (1992) HLA-A2.1 associated peptides from a mutant cell line: a second pathway of antigen presentation. Science 255: 1264–1266

    Article  PubMed  CAS  Google Scholar 

  • Hershko A, Cienchover A (1992) The ubiquitin system for protein degradation. Annu Rev Biochem 61: 761–807

    Article  PubMed  CAS  Google Scholar 

  • Hicklin DJ, Kageshita T, Dellaratta DV, Boccaletti V, Ferrone S (1996) Defects in HLA class I antigen presentation machinery in melanoma cells. (In press)

    Google Scholar 

  • Higgins CF (1994) Introduction: the ABC transporter channel superfamily: an overview. Semin Cell Biol 4:1–5

    Article  Google Scholar 

  • Hill A, Ploegh H (1995) Getting the inside out: The transporter associated with antigen processing and the presentation of viral antigen. Proc Natl Acad Sci USA 92: 341–342

    Article  PubMed  CAS  Google Scholar 

  • Hosken NA, Bevan MJ (1992) An endogenous antigenic peptide bypasses the class I antigen presentation defect in RMA-S. J Exp Med 175. 719–729

    Article  PubMed  CAS  Google Scholar 

  • Kaklamanis L, Townsend A, Doussis-Anagnostopouloou IA, Mortensen N, Harris AL, Gatter KC (1994) Loss of major histocompatibility complex-encoded transporter associated with antigen presentation ( TAP) in colorectal cancer. Am J Pathol 145: 505–509

    PubMed  CAS  Google Scholar 

  • Kaklamanis L, Leek R, Koukourakis M, Gatter KC, Harris AL (1995). Loss of transporter in antigen processing 1 transport protein and major histocompatibility complex class I molecules in primary and metastatic breast cancer. Cancer Res 55 5191–5194

    PubMed  CAS  Google Scholar 

  • Khanna R, Burrows SR, Argaet V, Moss D (1994) Endoplasmic reticulum signal sequence facilitated transport of peptide epitopes restores immunogenicity of an antigen processing defective tumor cell line. Int Immunol 6: 639–645

    Article  PubMed  CAS  Google Scholar 

  • Kovacsovics-Banikowski M, Rock KL (1995) A phagosome to cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267: 243–246

    Article  Google Scholar 

  • Ljunggren HG, Kärre K (1985) Host resistance directed selectively against H-2 defi-cient lymphoma variants: analysis of the mechanism. J Exp Med 1162: 1745–1749

    Article  Google Scholar 

  • Ljunggren HG, Stam NJ, Öhlen C, Neefjes JJ, Hoglund P, Heemels MT, Bastin J, Schumacher TNM, Townsend A, Kärre K, Ploegh HL (1990) Empty MHC class I molecules come out in the cold. Nature 346: 476–480

    Article  PubMed  CAS  Google Scholar 

  • Maudsley DJ, Pound JD (1991) Modulation of MHC antigen expression by viruses and oncogenes. Immunol Today 12: 429–431

    Article  PubMed  CAS  Google Scholar 

  • Michalek MT, Grant EP, Gramm C, Goldberg AL, Rock KL (1993) A role for the ubiquitin-dependent proteolytic pathway in MHC class I restricted antigen presentation. Nature 363: 552–554

    Article  PubMed  CAS  Google Scholar 

  • Momburg F, Ziegler A, Harpprecht J, Möller P, Moldenhauer G, Hämmerling GJ (1989) Selective loss of HLA-A or HLA-B antigen expression in colon carcinoma. J Immunol 142: 352–358

    PubMed  CAS  Google Scholar 

  • Momburg F, Ortiz-Navarette V, Neefjes J, Goulmy E, van de Wal Y, Spits H, Powis SJ, Butcher GW, Howard JC, Walden P, Hämmerling GJ (1992) Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature 360: 174–177

    Article  PubMed  CAS  Google Scholar 

  • Momburg F, Roelse J, Hämmerling GJ, Neefjes JJ (1994) Peptide size selection by the major histocompatibility complex encoded peptide transporter. J Exp Med 179: 1613–1623

    Article  PubMed  CAS  Google Scholar 

  • Monaco JJ, Cho S, Attaya M (1990) Transport protein genes in the murine MHC: possible implications for antigen processing. Science 250: 1723–1726

    Article  PubMed  CAS  Google Scholar 

  • Müller KM, Ebensberger C, Tampé R (1994) Nucleotide binding to the hydrophilic C-terminal domain of the transporter associated with antigen processing TAP. J Biol Chem 269: 14032–14037

    PubMed  Google Scholar 

  • Natali PG, Nicotra MR, Bigotti A, Venturo I, Marcenaro L, Giacomini P, Russo C (1989) Selective changes in the expression of HLA class I polymorphic determinants in human solid tumors. Proc Natl Acad Sci USA 86: 6719–6723

    Article  PubMed  CAS  Google Scholar 

  • Neefjes JJ, Momburg F, Hämmerling G (1993) Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261: 769–771

    Article  PubMed  CAS  Google Scholar 

  • Ortiz-Navarette V, Seelig A, Gernold M, Frentzel S, Kloetzel JM, Hämmerling GJ (1991) Subunit of the “20S” proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex. Nature 353: 662–664

    Article  Google Scholar 

  • Restifo NP, Esquivel F, Kawakami Y, Yewdell JW, Mule JJ, Rosenberg SA, Bennink JR (1993) Identification of human cancers deficient in antigen processing. J Exp Med 177: 265–272

    Article  PubMed  CAS  Google Scholar 

  • Rivett AJ (1993) Proteasomes: multicatalytic proteinase complexes. Biochem J 291: 1–10

    PubMed  CAS  Google Scholar 

  • Rock KL (1996) A new foreign policy: MHC class I molecules monitor the outside world. Immunol Today 17: 131–137

    Article  PubMed  CAS  Google Scholar 

  • Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78: 761–771

    Article  PubMed  CAS  Google Scholar 

  • Roelse J, Grommé M, Momburg F, Hämmerling GJ, Neefjes JJ (1994) Trimming of TAP-translocated peptides in the endoplasmic reticulum and in the cytosol during recycling. J Exp Med 180: 1591–1597

    Article  PubMed  CAS  Google Scholar 

  • Rotem-Yehudar R, Winograd S, Sela S, Coligan JE, Ehrlich R (1994) Downregulation of peptide transporter genes in cell lines transformed with highly oncogenic adenovirus 12. J Exp Med 180: 477–488

    Article  PubMed  CAS  Google Scholar 

  • Rotem-Yehudar R, Groetrupp M, Soza A, Kloetzel PM, Ehrlich R (1996) LMP-associated proteolytic activities and TAP-dependent peptide transport for class I MHC molecules are suppressed in cell lines transformed by the highly oncogenic adenovirus 12. J Exp Med 183: 499–514

    Article  PubMed  CAS  Google Scholar 

  • Rowe M, Khanna R, Jacob CA, Argaet V, Kelly A, Powis S, Belich M, Croom-Carter D, Lee S, Burrows SR, Trowsdale J, Moss DJ, Rickinson AB (1995) Restoration of endogenous antigen processing in Burkitt’s lymphoma cells by Epstein-Barr virus latent membrane protein-1: coordinate up-regulation of peptide transporters and HLA-class I antigen expression. Eur J Immunol 25: 1374–1384

    Article  PubMed  CAS  Google Scholar 

  • Ruiz-Cabello F, Klein E, Garrido F (1991) MHC antigens on human tumors. Immunol Letters 29: 181–189

    Article  CAS  Google Scholar 

  • Salcedo M, Momburg F, Hämmerling GJ, Ljunggren HG (1994) Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells. J Immunol 152: 1702–1708

    PubMed  CAS  Google Scholar 

  • Sanda MG, Restifo NP, Walsh JC, Kawakami Y, Nelson WG, Pardoll DM, Simons JW (1995) Molecular characterization of defective antigen processing in human prostate cancer. J Natl Cancer Inst 87: 280–285

    Article  PubMed  CAS  Google Scholar 

  • Schrier PI, Bernards R, Vaessen RTMJ, Houweling A, van der Eb AJ (1983) Expression of class I MHC switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature 305: 771–775

    Article  PubMed  CAS  Google Scholar 

  • Schumacher TNM, Bruijn MLH, Vernie LN, Kast WM, Melief CJM, Neefjes JJ, Ploegh HL (1991) Peptide selection of MHC class I molecules. Nature 350: 703–706

    Article  PubMed  CAS  Google Scholar 

  • Schumacher TNM, Kantesaria DV, Heemels MT, Ashton-Rickardt PG, Shepherd JC, Früh K, Young Y, Peterson PA, Tonegawa S, Ploegh HL (1994) Peptide length and sequence specificity of mouse TAP1/TAP2 translocator. J Exp Med 179: 533–540

    Article  PubMed  CAS  Google Scholar 

  • Seliger B, Höhne A, Knuth A, Bernhard H et al (1996a) Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression. Cancer Res 56: 1756–1760

    PubMed  CAS  Google Scholar 

  • Seliger B, Höhne A, Knuth A, Bernhard H, Ehring B, Tampé R, Huber C (1996b) Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. Clin Cancer Res 2: 1427–1433

    PubMed  CAS  Google Scholar 

  • Shemesh J, Ehrlich R (1993) Aberrant biosynthesis and transport of class I major histocompatibility complex molecules in cells transformed with highly oncogenic human adenoviruses. J Biol Chem 268: 15704–15711

    PubMed  CAS  Google Scholar 

  • Shemesh J, Rotem-Yeduhar R, Ehrlich R (1991) Transcriptional and posttranscriptional regulation of class I major histocompatibility complex genes following infection and transformation with human adenoviruses. J Virol 65: 5544–5548

    PubMed  CAS  Google Scholar 

  • Shepherd JC, Schumacher TNM, Ashton-Rickardt PG, Imaeda S, Ploegh HL, Janeway CA Jr, Tonegawa S (1993) TAPi-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell 74: 577–584

    Article  PubMed  CAS  Google Scholar 

  • Spies T, DeMars RA (1991) Restored expression of the major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature 351: 323–324

    Article  PubMed  CAS  Google Scholar 

  • Spies T, Bresnahan M, Bahram S, Arnold D, Blanck G, Mellins E, Pious D, DeMars R (1990) A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway. Nature 348: 744–747

    Article  PubMed  CAS  Google Scholar 

  • Suh WK, Cohen-Doyle M, Früh K, Wang, K, Peterson PA, Williams DB (1994) Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264: 1322–1326

    Article  PubMed  CAS  Google Scholar 

  • Tanaka K, Isselbacher A, Khoury G, Jay G (1985) Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene. Science 228: 26–33

    Article  PubMed  CAS  Google Scholar 

  • Ting JPY, Baldwin AS (1993) Regulation of MHC gene expression. Curr Opin Immunol 5: 8–16

    Article  PubMed  CAS  Google Scholar 

  • Townsend A, Bodmer H (1989) Antigen recognition by class I-restricted T lymphocytes. Annu Rev Immunol 7: 601–624

    Article  PubMed  CAS  Google Scholar 

  • Townsend A, Öhlén C, Bastin J, Ljunggren HG, Foster L, Kärre K (1989) Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340: 443–448

    Article  PubMed  CAS  Google Scholar 

  • Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A (1990) Sequences encoded in the class II region of the MHC related to the “ABC” superfamily of transporters. Nature 348: 741–744

    Article  PubMed  CAS  Google Scholar 

  • Uebel S, Meyer TH, Kraas W, Kienle S, Jung G, Wiesmüller KH, Tampé R (1995) Requirements for peptide binding to the human transporter associated with antigen-processing revealed by peptide scans and complex peptide libraries. J Biol Chem 270: 18512–18516

    Article  PubMed  CAS  Google Scholar 

  • van Endert PM, Tampé R, Meyer TH, Tisch R, Bach JF, McDevitt HO (1994) A sequential model of peptide binding and transport by the transporters associated with antigen processing. Immunity 1: 491–500

    Article  PubMed  Google Scholar 

  • van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S (1992) TAP]. mutant mice are deficient in antigen presentation, surface class I molecules and CD4 -CD8+ T cells. Cell 71: 1205–1214

    Article  PubMed  Google Scholar 

  • Wei ML, Cresswell P (1992) HLA-A2 molecules in an antigen processing mutant cell contain signal sequence derived peptides. Nature 356: 443–446

    Article  PubMed  CAS  Google Scholar 

  • Wölfel T, Klehmann E, Müller C, Schutt KH, Meyer zum Büschenfelde KH, Knuth A (1989) Lysis of melanoma cells by autologous cytolytic T cell clones: identification of human histocompatibility leukocyte antigen Az as a restriction element for three different antigens. J Exp Med 170: 797–810

    Article  PubMed  Google Scholar 

  • Wölfel T, VanPel A, Brichard V, Schneider J, Seliger B, Meyer zum Büschenfelde KH, Boon T (1994) Two tyrosinase nonapeptides recognized on HLA-A2 melanomas by autologous cytolytic T lymphocytes. Eur J Immunol 24: 759–764

    Article  PubMed  Google Scholar 

  • Wright KL, White LC, Kelly A, Beck S, Trowsdale J, Ting JP-Y (1995) Coordinate regulation of the human TAP1. and LMP2 genes from a shared bidirectional promoter. J Exp Med 181: 1459–1471

    Article  PubMed  CAS  Google Scholar 

  • Yang Y, Früh K, Chambers J, Waters JB, Wu L, Spies T, Petersson PA (1992) Major histocompatibiliy complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules. J Biol Chem 267: 11669–11672

    PubMed  CAS  Google Scholar 

  • Yewdell JW, Bennink JR (1992) Cell biology of antigen processing and presentation to MHC class I molecule restricted T lymphocytes. Annu Rev Immunol 52: 1–123

    Article  CAS  Google Scholar 

  • Zinkernagel RM, Doherty PC (1979) MHC restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 27: 51–177

    Article  PubMed  CAS  Google Scholar 

  • Zweerink HJ, Gammon MC, Utz U, Sauma SY, Harrer T, Hawkins JC, Sirotina A, Hermes JD, Walker BD, Biddison WE (1993) Presentation of endogenous peptides to MHC class I restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells. J Immunol 150: 1763–1771

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. B. Seliger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Huber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Immunologie der Universität Wien, Borschkegasse 8 a, 1090, Wien, Austria

    Martha M. Eibl

  2. Department of Hematology, Johannes Gutenberg Universität, Langenbeckstr. 1, 55101, Mainz, Germany

    Christoph Huber

  3. Abteilung für Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Hugstetter Str. 55, 79106, Freiburg, Germany

    Hans H. Peter

  4. Pädiatrische Pneumologie und Immunologie, Universitäts-Klinikum Rudolf-Virchow, Standort Charlottenburg Heubnerweg 6, 14059, Berlin, Germany

    Ulrich Wahn

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Seliger, B., Huber, C. (1997). Deficiencies of the MHC Class I Antigen Processing and Presentation Machinery in Tumor Cells. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60562-8_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60562-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61755-6

  • Online ISBN: 978-3-642-60562-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation