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Parvovirus B19: Nicht nur das Exanthem der Ringelröteln

  • Tino F. Schwarz
Conference paper
Part of the Fortschritte der praktischen Dermatologie und Venerologie book series (DERMATOLOGIE, volume 15)

Zusammenfassung

Das klinische Bild des Erythema infectiosum wurde erstmals im Jahr 1886 von Tschamer beschrieben. 1975 konnte Cossart et al. ein bis dahin unbekanntes Virus, das später als humanes Parvovirus B19 (B19) bezeichnet wurde, im Plasma von Blutspendern nachweisen [8]. 1981 gelang der Nachweis einer kausalen Rolle von B19 in der Auslösung aplastischer Krisen und 1983 wurde gezeigt, daß B19 der Erreger des Erythema infectiosum ist. Seither hat B19 seinen festen Platz in der klinischen Virologie, sowohl in der Diagnostik als auch in der Differentialdiagnose, gefunden [38, 43]. In den letzten Jahren wurde zudem gezeigt, daß B19 nicht nur das Erythema infectiosum und aplastische Krisen verursacht, sondern eine Reihe weiterer, zum Teil schwerer Krankheitsbilder auslösen kann [24, 48, 51]. Über die zugrundeliegenden molekularen Prozesse, welche die Symptomvielfalt dieser Infektion bedingen, gibt es bisher nur wenig Befunde. Wenngleich inzwischen der zelluläre Rezeptor von B19 identifiziert werden konnte [4], so ist weiterhin unklar, wie es beispielsweise zum klassischen Bild des Erythema infectiosum kommt.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

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  • Tino F. Schwarz

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