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Genetic and Molecular Biology Techniques for the Assessment of Vascular Disease

  • Chapter
Diagnostics of Vascular Diseases

Abstract

The health of the circulatory system depends largely on proper functioning of the heart and the vessel wall. The cells in the vessel wall, in particular smooth muscle and endothelial cells, respond to humoral factors, such as growth factors, hormones, and cytokines, and interact with adjacent cells and with their extracellular matrix. Changes in these interactions may cause dysfunctioning of the vascular cells resulting in, among other things, arteriosclerosis, hypertension, thrombosis, or vascular leakage. In comparison with coagulation factors and lipoproteins, which are constituents of plasma and can be determined in the peripheral blood, the functioning of the vessel wall cells is less easy to evaluate from plasma or serum samples. Only a limited number of secretion products, usually from the endothelium, can be assayed in the blood, e.g., von Willebrand factor, tissue-type plasminogen activator, endothelin, and plasminogen activator inhibitor-1.

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Authors
  1. M. P. M. de Maat
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  2. P. H. A. Quax
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  3. V. W. M. van Hinsbergh
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Editors and Affiliations

  1. Kardiologische Gemeinschaftspraxis, Saalbaustraße 27, 64283, Darmstadt, Germany

    Peter Lanzer

  2. Department of Radiology, The University of Chicago Hospitals, 5841 South Maryland Avenue, 60637, Chicago, IL, USA

    Martin Lipton

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© 1997 Springer-Verlag Berlin Heidelberg

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de Maat, M.P.M., Quax, P.H.A., van Hinsbergh, V.W.M. (1997). Genetic and Molecular Biology Techniques for the Assessment of Vascular Disease. In: Lanzer, P., Lipton, M. (eds) Diagnostics of Vascular Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60512-3_20

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  • DOI: https://doi.org/10.1007/978-3-642-60512-3_20

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