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Genetic Alterations in Human Tumors

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Genetic Instability and Tumorigenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 221))

Abstract

At the level of the cell, cancer is essentially a genetic disease. Studies from multiple disciplines, including molecular biology, somatic cell genetics, genetic epidemiology, tumor virology, chemical carcinogenesis, and others, have converged over the last few decades to provide many fundamental insights into the genetic basis of cancer. These studies have shown that the genesis of malignant tumors is dependent on the accumulation of a series of DNA alterations that generally occur somatically, but can also be inherited in the germ line. These alterations have a cumulative effect on many important cellular processes that become dysfunctional in cancers, including growth control, differentiation, and interactions of the affected cell with its microenvironment.

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  1. Departments of Pathology, Gynecology and Obstetrics, and Oncology, The Johns Hopkins University School of Medicine, Room 659 Ross Research Building, 720 Rutland Avenue, Baltimore, 21205, MD, USA

    K. R. Cho & L. Hedrick

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  1. K. R. Cho
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  1. Johns Hopkins Hospital, Ross 345, 720 Rutland Avenue, Baltimore, MD, 21205, USA

    Michael B. Kastan M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Cho, K.R., Hedrick, L. (1997). Genetic Alterations in Human Tumors. In: Kastan, M.B. (eds) Genetic Instability and Tumorigenesis. Current Topics in Microbiology and Immunology, vol 221. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60505-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-60505-5_7

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