Lupus anticoagulants are a heterogeneous group of autoantibodies directed against hemostatically active phospholipids and phospholipid-protein complexes. The presence of lupus anticoagulants can predispose to thrombosis and recurrent abortion. Both arterial and venous thrombosis have been described. Reduced anticoagulant activity of activated protein C has been discussed as a possible pathophysiologic mechanism. Various functional and immunologic tests are available for detecting lupus anticoagulants. The definitive diagnosis of a lupus anticoagulant requires a positive result in two independent functional tests or the simultaneous detection of a lupus anticoagulant in one functional and one immunologic test. Treatment aims at the prevention of thromboembolic complications, so patients should remain on oral anticoagulation until lupus anticoagulant parameters have normalized.
KeywordsSystemic Lupus Erythematosus Oral Anticoagulation Lupus Anticoagulant Anticardiolipin Antibody Immunologic Test
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