TLS-CHOP and the Role of RNA-Binding Proteins in Oncogenic Transformation
Many of the genes found to be altered in cancer cells encode proteins with regulatory effects on the pattern of gene expression. Some, like growth factor receptors and adapter molecules, do so indirectly by interfering with signaling pathways that eventually converge on a nuclear target. Others are more directly associated with regulation of gene expressions, being either DNA-binding transcription factors or proximate regulators of transcription factor function.
KeywordsSynovial Sarcoma Transcriptional Machinery Myxoid Liposarcoma Desmoplastic Small Round Cell Tumor Transcriptional Activation Domain
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