Transcription Factors of the bHLH and LIM Families: Synergistic Mediators of T Cell Acute Leukemia?
Patients with T cell acute lymphoblastic leukemia (T-ALL) often harbor tumor-specific chromosome translocations in their malignant cells (reviewed by Raimondi 1993). In an effort to understand the etiology of T-ALL, many investigators have sought to identify the genes that are altered as a consequence of these chromosomal defects (Rabbitts 1994). To date these studies have uncovered nine presumptive proto-oncogenes, each of which can be activated in T-ALL cells by aberrant juxtaposition with the T cell receptor sequences on chromosomes 7 or 14 (Hwang and BAER 1995). For instance, the (8;14) (q24;q11) translocation serves to deregulate the MYC gene on chromosome 8 by recombining it with the T cell receptor α/δ chain locus on chromosome 14. The various proto-oncogenes implicated in T-ALL are listed in Table 1, along with the major chromosome translocations that are responsible for their activation.
KeywordsAcute Lymphoblastic Leukemia Amino Acid Motif bHLH Protein bHLH Domain bHLH Motif
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