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E2A-Pbx1 Induces Growth, Blocks Differentiation, and Interacts with Other Homeodomain Proteins Regulating Normal Differentiation

  • M. P. Kamps
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 220)

Abstract

Arrested differentiation is a hallmark of progenitor cell leukemias as well as many other types of human cancer. It is hypothesized that such progenitor cell cancers express oncoproteins that block differentiation. The E2A-Pbx1 oncoprotein that results from the t(1;19) chromosomal translocation of childhood pre-B cell acute lymphoblastic leukemia (pre-B ALL) is a fascinating oncoprotein because it blocks differentiation and physically interacts with homeodomain proteins, which are effectors of normal differentiation. These properties suggest the attractive hypothesis that E2A-Pbx1 blocks pre-B cell differentiation by interfering with the ability of other homeodomain proteins to orchestrate terminal B cell differentiation.

Keywords

Acute Lymphoblastic Leukemia Homeobox Gene Normal Differentiation Cooperative Binding Homeodomain Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. P. Kamps
    • 1
  1. 1.Department of PathologyUniversity of California, San Diego, School of MedicineLa JollaUSA

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