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E2A-Pbx1 Induces Growth, Blocks Differentiation, and Interacts with Other Homeodomain Proteins Regulating Normal Differentiation

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Chromosomal Translocations and Oncogenic Transcription Factors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 220))

Abstract

Arrested differentiation is a hallmark of progenitor cell leukemias as well as many other types of human cancer. It is hypothesized that such progenitor cell cancers express oncoproteins that block differentiation. The E2A-Pbx1 oncoprotein that results from the t(1;19) chromosomal translocation of childhood pre-B cell acute lymphoblastic leukemia (pre-B ALL) is a fascinating oncoprotein because it blocks differentiation and physically interacts with homeodomain proteins, which are effectors of normal differentiation. These properties suggest the attractive hypothesis that E2A-Pbx1 blocks pre-B cell differentiation by interfering with the ability of other homeodomain proteins to orchestrate terminal B cell differentiation.

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Authors and Affiliations

  1. Department of Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA, 92093-0612, USA

    M. P. Kamps

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  1. M. P. Kamps
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Editors and Affiliations

  1. The Wistar Institute, 3601 Spruce Street, 19104-4268, Philadelphia, Pennsylvania, USA

    Frank J. Rauscher III Ph.D. (Associate Professor Chair, Molecular Genetics Program) (Associate Professor Chair, Molecular Genetics Program)

  2. Division of Oncovirology, BCC 239 Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, California, USA

    Peter K. Vogt Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Kamps, M.P. (1997). E2A-Pbx1 Induces Growth, Blocks Differentiation, and Interacts with Other Homeodomain Proteins Regulating Normal Differentiation. In: Rauscher, F.J., Vogt, P.K. (eds) Chromosomal Translocations and Oncogenic Transcription Factors. Current Topics in Microbiology and Immunology, vol 220. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60479-9_2

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  • DOI: https://doi.org/10.1007/978-3-642-60479-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64424-5

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