Peliosis Hepatis, Rodents

  • Peter Bannasch
  • Klaus Wayss
  • Heide Zerban
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Macroscopically, peliosis hepatis is best visible at the surface of the liver. The lesion is seen as blood-filled, thin-walled cavities projecting above the liver surface (Fig. 127). The blood-filled spaces stand out clearly as dark areas against the otherwise brown liver tissue. Large peliotic lesions may also be identified at the cut surface. Frequently, however, it is extremely difficult or even impossible to detect peliosis with the naked eye after the animal has died spontaneously under conditions with a weak blood supply to the liver. When the liver is removed from anesthetized animals after laparotomy, peliosis is readily visible only as long as the liver is connected with the blood circulation, but usually becomes invisible when the blood is lost during removal of the organ.

Synonyms

Blood cyst angiectasis phlebectetic or sinusoidal peliosis hepatis parenchymal peliosis hepatis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bagheri SA, Boyer L (1974) Peliosis hepatis associated with androgenic-anabolic steroid therapy. A severe form of hepatic injury. Ann Int Med 81:610–618PubMedGoogle Scholar
  2. Baläzs M (1988) Sinusoidal dilatation of the liver in patients on oral contraceptives. Electron microscopical study of 14 cases. Exp Pathol 35:231–237PubMedGoogle Scholar
  3. Bannasch P, Zerban H (1990) Tumours of the liver. In: Turusov VS, Mohr U (eds) Pathology of tumours in laboratory animals, vol I: tumours of the rat, 2nd edn. IARC, Lyon, pp 199–240 (IARC scientific publications no 99)Google Scholar
  4. Bannasch P, Mayer D, Hacker HJ (1980) Hepatocellular glycogenesis and hepatocarcinogenesis. Biochim Biophys Acta 605:217–245PubMedGoogle Scholar
  5. Bannasch P, Bloch M, Zerban H (1981) Spongiosis hepatis. Specific changes of perisinusoidal liver cells induced in rats by N-nitrosomorpholine. Lab Invest 44:252–264PubMedGoogle Scholar
  6. Björk O, Eklöf O, Willi U, Ähström L (1985) Veno-occlusive disease and peliosis of the liver complicating the course of Wilms’ tumour. Acta Radiol Diagn 26:589–597Google Scholar
  7. Czapar CA, Weldon-Linne CM, Moore DM, Rhone DP (1986) Peliosis hepatis in the acquired immunodeficiency syndrome. Arch Pathol Lab Med 110:611–613PubMedGoogle Scholar
  8. Druckrey H, Preussmann R, Ivankovic S, Schmähl D (1967) Organotropic carcinogenic effects of 65 various N-nitroso-compounds on BD rats. Z Krebsforsch 69:103–201PubMedCrossRefGoogle Scholar
  9. Endo H, Murakami T, Nishimoto I, Sekine I, Yokoyama M (1987) Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer. Acta Pathol Jpn 37:795–806PubMedGoogle Scholar
  10. Hadjiolov D, Markow D (1973) Fine structure of heman-gioendothelial sarcomas in the rat liver induced with N-Nitrosodimethylamine. Arch Geschwulstforsch 42:120–126PubMedGoogle Scholar
  11. Herrold KM (1967) Histogenesis of malignant liver tumors induced by dimethylnitrosamine. An experimental study in Syrian hamsters. J Natl Cancer Inst 39:1099–1111PubMedGoogle Scholar
  12. Kühböck J, Radaszkiewicz T, Walek H (1975) Peliosis hepatis, eine Komplikation der Anabolikatherapie. Med Klin 70:1602–1607PubMedGoogle Scholar
  13. Lee KP (1983) Peliosis hepatis-like lesions in aging rats. Vet Pathol 20:410–423PubMedCrossRefGoogle Scholar
  14. Magee PN, Montesano R, Preussmann R (1976) N-nitroso compounds and related carcinogens. In: Searle CE (ed) Chemical carcinogens. ACS Monogr Ser 173:491–625Google Scholar
  15. Maltoni C, Lefemine G (1974) Carcinogenicity bioassays of vinylchloride 1. Research plan and early results. Environ Res 7:387–405CrossRefGoogle Scholar
  16. Mohr U, Haas H, Hilfrich J (1974) The carcinogenic effects of dimethylnitrosamine and nitrosomethylurea in European hamsters (Cricetus cricetus L.). Br J Cancer 29: 359–364PubMedCrossRefGoogle Scholar
  17. Nadell J, Kosek J (1977) Peliosis hepatis. Twelve cases associated with oral androgen therapy. Arch Pathol Lab Med 101:405–410PubMedGoogle Scholar
  18. Nissen ED, Kent DR, Nissen SE (1977) Etiologic factors in the pathogenesis of liver tumors associated with oral contraceptives. Am J Obstet Gynecol 127:61–66PubMedGoogle Scholar
  19. Popper H, Selikoff U, Maltoni C, Squire RA, Thomas LB (1977) Comparison of neoplastic hepatic lesions in man and experimental animals. In: Hiatt HH, Watson JD, Winsten JA (eds) Human risk assessment. Cold Spring Harbor Conference on Cell Proliferation, vol 4: origins of human cancer. Cold Spring Harbor, Cold Spring Harbor Laboratory, pp 1359–1382Google Scholar
  20. Rao MS, Reddy JK (1977) Induction of malignant vascular tumors of the liver in guinea pigs treated with 2,2’-dihydroxy-di-n-propylnitrosamine. J Natl Cancer Inst 58:387–392PubMedGoogle Scholar
  21. Reznik G (1975) The carcinogenic effect of dimethylnitrosamine on the Chinese hamster (Cricetulus griseus). Cancer Lett 1:25–28PubMedCrossRefGoogle Scholar
  22. Reznik G, Mohr U, Kmoch N (1976) Carcinogenic effects of different nitroso-compounds in Chinese hamsters. 1. Dimethylnitrosamine and N-diethylnitrosamine. Br J Cancer 33:411–418PubMedCrossRefGoogle Scholar
  23. Ruebner BH, Watanabe K, Wand JS (1970) Lytic necrosis resembling peliosis hepatis produced by lasiocarpine in the mouse liver. A light and electron microscopic study. Am J Pathol 60:247–271PubMedGoogle Scholar
  24. Schauer A, Kunze E (1976) Tumours of the liver. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol 1, Tumours of the rat, part 2. IARC, Lyon, pp 41–61 (IARC scientific publications no 6)Google Scholar
  25. Schmähl D, Thomas C (1965) Dosis-Wirkungs-Beziehungen bei der Erzeugung von Hämangioendotheliomen der Leber bei Meusen durch Diethylnitrosamin. Z Krebsforsch 66:533–535CrossRefGoogle Scholar
  26. Schmidt H, Ullrich K, von Lengerke HJ, Peters PE (1991) Peliosis hepatis with type 1 glycogen storage disease. J Inherited Metab Dis 14:831–832PubMedCrossRefGoogle Scholar
  27. Scoazec JY, Marche C, Girard PM, Houtmann J, Durand-Schneider AM, Saimot AG, Benhamou JP, Feldmann G (1988) Peliosis hepatis and sinusoidal dilatation during infection by the human immunodeficiency virus (HIV). An ultrastructural study. Am J Pathol 131:38–47PubMedGoogle Scholar
  28. Seawright AA, Francis J (1971) Peliosis hepatis. A specific lesion in St. George’s disease of cattle. Aust Vet J 47:91–99PubMedCrossRefGoogle Scholar
  29. Soe KL, Soe M, Gluud CN (1992) Liver pathology associated with the use of anabolic-androgenic steroids. Liver 12:73–79PubMedGoogle Scholar
  30. Spellberg MA, Mirro J, Chowdhury L (1979) Hepatic sinusoidal dilatation related to oral contraceptives. A study of two patients showing ultrastructural changes. Am J Gastroenterol 72:248–252PubMedGoogle Scholar
  31. Spycher MA, Gitzelmann R (1971) Glycogenesis type I (glu-cose-6-phosphatase deficiency): ultrastructural alterations of hepatocytes in a tumor bearing liver. Virchows Arch [B] Cell Pathol 8:133–142Google Scholar
  32. Takahara S, Ihara H, Ichikawa Y, Nagano S, Fukunishi T, Sonoda T, Shinji Y (1987) Prospective study and long-term follow-up of liver damage in renal transplant recipients. Transplant Proc 19:2221–2224PubMedGoogle Scholar
  33. Takayama S (1968) The histological and autoradiographical studies of mouse liver during the course of carcinogenesis by dimethylnitrosamine. Z Krebsforsch 71:246–254PubMedCrossRefGoogle Scholar
  34. Taxy JB (1978) Peliosis: a morphologic curiosity becomes an iatrogenic problem. Hum Pathol 9:331–340PubMedCrossRefGoogle Scholar
  35. Terracini B, Palestro G, Gigliardi MR, Montesano G (1966) Carcinogenicity of dimethylnitrosamine in Swiss mice. Br J Cancer 20:871–876PubMedCrossRefGoogle Scholar
  36. Thomas LB, Popper H, Berk PD, Selikoff I, Falk H (1975) Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti’s syndrome) to angiosarcoma. N Engl J Med 292:17–22PubMedCrossRefGoogle Scholar
  37. Tomatis L, Magee PN, Shubik P (1964) Induction of liver tumors in the Syrian golden hamster by feeding dimethylnitrosamine. J Natl Cancer Inst 33:341–345PubMedGoogle Scholar
  38. Trainin N (1963) Neoplastic nature of liver “blood cysts” induced by urethan in mice. J Natl Cancer Inst 31:1489–1499PubMedGoogle Scholar
  39. Tuchweber B, Kovacs K, Khandekar JD, Garg BD (1973) Peliosis-like changes induced by phalloidin in the rat liver. A light and electron microscopic study. J Med 4:327–345PubMedGoogle Scholar
  40. Ward JM (1981) Morphology of foci of altered hepatocytes and naturally-occurring hepatocellular tumors in F344 rats. Virchows Arch Pathol Anat 390:339–345PubMedGoogle Scholar
  41. Wayss K, Bannasch P, Mattern J, Volm M (1979) Vascular liver tumors induced in Mastomys (Praomys) natalensis by single or twofold administration of dimethylnitrosamine. J Natl Cancer Inst 62:1199–1207PubMedGoogle Scholar
  42. Wright JA, Marsden AM, Willets JM, Orton TC (1991) Hepatocarcinogenic effect of vinyl carbamate in the C57B1/ lOJ strain mouse. Toxicol Pathol 19:258–265PubMedCrossRefGoogle Scholar
  43. Yanoff M, Rawson AJ (1964) Peliosis hepatis. An anatomic study with demonstration of two varieties. Arch Pathol 77:159–165PubMedGoogle Scholar
  44. Zafrani ES, Cazier A, Baudelot AM, Feldmann G (1984) Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol 114:349–359PubMedGoogle Scholar
  45. Zafrani ES, Degos F, Guigui B, Durand-Schneider AM, Martin N, Flandrin G, Benhamou JP, Feldmann G (1987) The hepatic sinusoid in hairy cell leukemia: an ultrastructural study of 12 cases. Hum Pathol 18:801–807PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Peter Bannasch
  • Klaus Wayss
  • Heide Zerban

There are no affiliations available

Personalised recommendations