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Mechanisms and Genetics of Autoimmunity

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Book cover The Role of Immune Mechanisms in Cardiovascular Disease

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Abstract

The development of the immune system has been hypothesized to be a threepart process that discards useless cells (death by neglect), retains useful cells (positive selection), and deletes or inactivates dangerous cells (negative selection). Studies in the last few years in mice transgenic for antigen receptors have strongly indicated that this hypothesis is essentially correct (von Boehmer 1994; Nossal 1994). Although substantial information has recently been acquired about the editing process by which self-tolerance is imposed, our understanding of the mechanisms and genetic basis of pathogenic autoimmune syndromes is far from resolved.

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Authors and Affiliations

  1. Immunology Department, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA, 92037, USA

    A. N. Theofilopoulos

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  1. A. N. Theofilopoulos
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Editors and Affiliations

  1. Abteilung für Kardiologie/Pulmologie, Universitätsklinikum Benjamin Franklin der Freien Universität Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Peter Schwimmbeck  & 

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© 1997 Springer-Verlag Berlin Heidelberg

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Theofilopoulos, A.N. (1997). Mechanisms and Genetics of Autoimmunity. In: Schultheiss, HP., Schwimmbeck, P. (eds) The Role of Immune Mechanisms in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60463-8_1

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  • DOI: https://doi.org/10.1007/978-3-642-60463-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61358-9

  • Online ISBN: 978-3-642-60463-8

  • eBook Packages: Springer Book Archive

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