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Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System

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Drug Toxicity in Embryonic Development I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 124 / 1))

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Abstract

The vertebrate nervous system arises from a pseudostratified epithelium, the neural plate, that is formed from the dorsal ectoderm of the embryo. Development of the nervous system is marked by a number of morphological events that involve first the induction of “neural tissue”, and then the patterning and refinement of cell fate within this neural tissue. The end result of these morphogenetic events is the generation of topologically defined classes of neurons each with distinct patterns of interconnections and neurotransmitter phenotypes, together with various glial cell types and other accessory cells such as the ependymal cells that line the meninges.

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Authors
  1. J. D. Burrill
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  2. H. Saueressig
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  3. M. Goulding
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Editor information

Editors and Affiliations

  1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA

    Robert J. Kavlock Ph.D. (Director) (Director)

  2. Miami Valley Laboratories, The Procter and Gamble Company, P.O. Box 538707, 45253, Cincinnati, OH, USA

    George P. Daston Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Burrill, J.D., Saueressig, H., Goulding, M. (1997). Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System. In: Kavlock, R.J., Daston, G.P. (eds) Drug Toxicity in Embryonic Development I. Handbook of Experimental Pharmacology, vol 124 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60445-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-60445-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64408-5

  • Online ISBN: 978-3-642-60445-4

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