New Aspects of Peritoneal Pathology

  • M. Morganti
  • L. Tietze
  • B. Amo-Takyi
  • K. Tory
  • D. Budianto
  • U. Henze
  • C. Mittermayer
Conference paper


The peritoneum is a membranous structure consisting of a single layer of mesothelial cells and the subserosal stroma. The visceral peritoneum covers the surface of various organs and continues to the abdominal wall as the parietal peritoneum. This membrane creates a gliding surface, regulates the traffic of molecules and fluid, and plays an important role in some pathological conditions, particularly formation of fibrous adhesions, peritonitis, and implantation of metastatic cancer. The fibrinolytic and antifibrinolytic properties of mesothelial cells are partly regulated by cytokines. Tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β 1 and interleukin (IL)-1β in particular cause a shift toward antifibrinolytic activity. This may contribute to the decreased fibrinolytic activity of serosal biopsies during peritonitis. This observation and its relationship to formation of fibrous adhesion are discussed in detail in Chap. 10 of this volume. The inflammatory response of this membrane is regulated by expression of a variety of cytokines [1]. The cell-cell interaction is partly mediated by expression of inducible and constitutive cell adhesion molecules [2]. The early inflammatory response with edema, vasodilation, and hyperalgesia is probably augmented by mesothelial prostaglandin production (see Chap. 12, this volume). In this chapter, we will focus on the developmental and morphological aspects of the peritoneal membrane and discuss pathological aspects of primary and secondary neoplasms of the peritoneal cavity.


Surfactant Estrogen Adenocarcinoma Aldehyde Hexagonal 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • M. Morganti
  • L. Tietze
  • B. Amo-Takyi
  • K. Tory
  • D. Budianto
  • U. Henze
  • C. Mittermayer

There are no affiliations available

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