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Ultraviolett-A1-Therapie entzündlicher Hautkrankheiten

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Book cover Handbuch der dermatologischen Phototherapie und Photodiagnostik

Zusammenfassung

Die hochdosierte UVA1-Therapie („high-dose UVA1“) stellt ein neues phototherapeutisches Prinzip zur Behandlung entzündlicher Hauterkrankungen dar, das erstmals 1991 von Krutmann u. Schöpf [21] zur Behandlung der atopischen Dermatitis eingesetzt wurde. Zur hochdosierten UVA1-Therapie werden Bestrahlungsgeräte verwendet, die entweder eine Ganz- oder aber eine Teilkör-perbestrahlung mit UV-Strahlung im langwelligen UVA-Bereich, d.h. UVA1 (>340nm) (s.auch das Kap. L.Endres/R.Breit, Physikalische Grundlagen) in einem Dosisbereich bis zu 130 J/cm2 UVA1 erlauben [27]. Die therapeutische Effektivität der hochdosierten UVA1-Therapie für die atopische Dermatitis wird mittlerweile als gesichert angesehen [19]. Die Identifizierung der photoimmunologischen Wirkmechanismen, die der therapeutischen Effektivität der hochdosierten UVA1-Therapie zugrunde liegen, hat in der Folgezeit zudem zu einer Erweiterung des Indikationsspektrums geführt [18]. Diese Entwicklung deutet darauf hin, daß die hochdosierte UVA1-Therapie sich in den nächsten Jahren zu einem integralen Bestandteil der modernen photodermatologischen Therapie entwickeln könnte. So ist die anfängliche Beschränkung der Durchführung der UVA1-Therapie auf einige ausgewählte Universitäts-Hautkliniken bereits aufgehoben, d.h. die UVA1-Therapie wird nicht mehr nur von der Mehrzahl der Hautkliniken im Inland und zunehmend auch im europäischen Ausland, sondern auch von dermatologischen Praxen mit photodermatologischem Schwerpunkt angeboten.

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Authors
  1. Jean Krutmann
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  2. Helger Stege
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Editors and Affiliations

  1. Hautklinik, Heinrich-Heine-Universität, Moorenstraße 5, D-40225, Düsseldorf, Germany

    Jean Krutmann

  2. Universitätsklinik für Dermatologie, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, A-1090, Wien, Germany

    Herbert Hönigsmann

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© 1997 Springer-Verlag Berlin Heidelberg

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Krutmann, J., Stege, H. (1997). Ultraviolett-A1-Therapie entzündlicher Hautkrankheiten. In: Krutmann, J., Hönigsmann, H. (eds) Handbuch der dermatologischen Phototherapie und Photodiagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60425-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-60425-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64401-6

  • Online ISBN: 978-3-642-60425-6

  • eBook Packages: Springer Book Archive

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