Extrakorporale Photochemotherapie (Photopherese)

  • Robert Knobler
  • Franz Trautinger

Zusammenfassung

1987 wurde erstmals von Edelson et al. [15] über eine neue Therapiemodalität zur Behandlung kutaner T-Zell Lymphome berichtet. Das Verfahren erhielt den Namen Photopherese oder extrakorporale Photochemotherapie (EP) und findet derzeit bei einer zunehmenden Anzahl von Indikationen klinische Anwendung (s. unten). Bei der Photopherese werden Leukozyten aus dem peripheren Blut in Gegenwart des Photosensibilisators 8-Methoxypsoralen (8-MOP) außerhalb des Körpers mit ultrtaviolettem Licht A (UVA) bestrahlt, um anschließend dem patienten rückinfundiert zu werden. Leukozytenseparation und Bestrahlung werden mit einem eigens für diesen Zweck entwickelten Gerät durchgeführt, das aus einer Leukaphereseeinheit und einer Bestrahlungseinheit besteht. Bei einem Behandlungszyklus werden ungefähr 10–15% der gesamten zirkulierenden Leukozyten erreicht. Die Behandlung wird i. allg. an 2 aufeinanderfolgenden Tagen in 4wöchigen Abständen durchgeführt, wobei bei besonderen Indikationen die Intervalle verkürzt werden können.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Robert Knobler
  • Franz Trautinger

There are no affiliations available

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