Abstract
Peripheral blood basophils from patients with atopic eczema stimulated with the staphylococcal enterotoxins (SE) A, B, D, E and toxic shock syndrome toxin i (TSST-i) secreted significantly higher amounts of histamine and leukotriene C4 (LTC4) than healthy controls. Furthermore, priming experiments with IL-3, IL-8 and GM-CSF followed by stimulation with enterotoxins showed additional histamine and LTC4 release in the group of atopic eczema patients. Histamine and leukotriene generation from atopic basophils stimulated with staphylococcal enterotoxins may indicate a role of these toxins as possible allergens in at least a subgroup of patients with atopic eczema.
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References
Ring J, Abeck D, Neuber K. Atopic eczema: role of microorganisms on the skin surface. Allergy 1992; 47: 265–269
Leung DYM, Harbeck R, Bina P, Reiser RF, Yang E, Yang DA, Norris DA, Hanifìn JK, Sampson HA. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic der¬matitis. J Clin Invest 1993; 92: 1374–1380
Neuber K, Steinrücke K, Ring J. Staphylococcal enterotoxin B affects in vitro IgE synthesis, inter¬feron, interleukin-4 and interleukin-5 production in atopic eczema. Int Arch Allergy Immunol 1995; 107: 179–182
Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol (Stockh) 1980; 92: 44–47
Krüger S, Neuber K, Gruseck E, Ring J, Abeck D. Pityrosporum ovale extracts increase interleukin-4, interleukin-10 and IgE synthesis in patients with atopic eczema. Acta Derm Venereol (Stockh) 1995; 75: 357–360
Ruzicka T, Ring J. Role of inflammatory mediators in atopic eczema. In: handbook of atopiceczema. Eds.: ruzicka T, Ring J, Przybilla B. Berlin: Springer, 1991; p 245–255
de Weck AL, Dahinden CA, Bischoff S. Cytokines in the proceedings of the XVth congress of the European Academy of Allergology and Clinical Immunology. Eds.: Godard P, Bousquet J, Michel FB. Park Ridge: The Parthenon Publishing Group. 1992; p 67–74
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Neuber, K., Wehner, J., Hakansson, K., Ring, J. (1997). Staphylococcus aureus Enterotoxins Induce Histamine and Leukotriene Release in Patients with Atopic Eczema. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_35
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DOI: https://doi.org/10.1007/978-3-642-60419-5_35
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