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Neuropeptides, Nerve Growth Factor and Eczema

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New Trends in Allergy IV

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Abstract

Evidence indicates that peripheral nerve fibers play an active regulatory role during eczematous reactions. Many basic features of the inflammatory process are potentially subject to neuropeptidergic modulation, such as vascular changes, cellular trafficking, activation and trophism. Actually, in vivo and in vitro investigations suggest that neuropeptides are part of the complex network of mediators that initiate and maintain the eczematous process in the skin. In general, peptidergic fibers seem to exert a global protective role, but with specific and selective effects in the different phases. Evidence that the inflammatory process induces biochemical changes at a neuronal level has also been obtained. The possible mediators of the neuronal recruitment in the course of the eczematous reaction are still unknown. Nevertheless, nerve growth factor, which is locally increased during inflammatory processes and may induce peptidergic alterations, should be considered as a potential candidate molecule.

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Authors
  1. F. Fantini
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  2. C. Pincelli
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  3. A. Giannetti
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Editor information

Editors and Affiliations

  1. Klinik and Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Germany

    Johannes Ring

  2. Abt. Experimentelle Dermatologie und Allergologie, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Heidrun Behrendt

  3. Hautklinik/Allergieabteilung, Universitäts-Krankenhaus Eppendorf, Martinistraße 53, 20246, Hamburg, Germany

    Dieter Vieluf

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© 1997 Springer-Verlag Berlin Heidelberg

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Fantini, F., Pincelli, C., Giannetti, A. (1997). Neuropeptides, Nerve Growth Factor and Eczema. In: Ring, J., Behrendt, H., Vieluf, D. (eds) New Trends in Allergy IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60419-5_31

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  • DOI: https://doi.org/10.1007/978-3-642-60419-5_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64398-9

  • Online ISBN: 978-3-642-60419-5

  • eBook Packages: Springer Book Archive

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