Acute Effects of Air Pollutants in Asthma

  • H. Magnussen
  • R. A. Jörres
Conference paper

Abstract

The past few decades have generated increasing concern about the potential health risks due to air pollution. Much of the evidence regarding adverse effects of air pollutants has been derived from experimental exposures to sulphur dioxide (S02), nitrogen dioxide (N02), and ozone in healthy subjects and subjects with asthma. This short review will focus on some specific results obtained by this approach.

Keywords

Combustion Dioxide Ozone Hydrocarbon Histamine 

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References

  1. Bates D., et al.: Asthma attack periodicity: a study of hospital emergency visits in Vancouver. Environ Res (1990) 51–70PubMedCrossRefGoogle Scholar
  2. Bauer MA, et al.: Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis 134 (1986) 1203–1208PubMedGoogle Scholar
  3. Burnett RT, et al.: Effects of low ambient levels of ozone and sulfates on the frequency of respiratory admissions to Ontario hospitals. Environ Res 65 (1994) 172–194PubMedCrossRefGoogle Scholar
  4. Castillejos M., et al.: Effects of ambient ozone on respiratory function and symptoms in Mexico City schoolchildren. Am Rev Respir Dis 145 (1992) 276–282PubMedGoogle Scholar
  5. Cody RP, etal.: he effect of ozone associated with summertime photochemical smog on the frequency of asthma visits to hospital emergency departments. Environ Res 58 (1992) 184–194PubMedCrossRefGoogle Scholar
  6. Devalia LJ, et al.: Effect of nitrogen dioxiode and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation. Lancet 344 (1994) 1668–1671PubMedCrossRefGoogle Scholar
  7. Folinsbee LJ: Does nitrogen dioxide exposure increase airways responsiveness> Toxicol Indust Health 8 (1992) 273–283Google Scholar
  8. Hazucha MJ: Relationship between ozone exposure and pulmonary function changes. J Appl Physiol 62 (1987) 1671–1680PubMedCrossRefGoogle Scholar
  9. Hazucha MJ, et al.: Mechanisms of action of ozone on the human lung. J Appl Physiol 67 (1989) 1535–1541PubMedGoogle Scholar
  10. Horstman DH, et al.: Airway sensitivity of asthmatics to sulfur dioxide. Toxicol Environ Health 2 (1986) 289–298Google Scholar
  11. Horstman DH, et al.: Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am Rev Respir Dis 142 (1990) 1158–1163PubMedGoogle Scholar
  12. Jörres R, Magnussen H: Airways response of asthmatics after a 30 min exposure, at resting ventilation to 0.25 ppm NO2 or 0.5 ppm SO2. Eur Respir J 3 (1990) 132–137PubMedGoogle Scholar
  13. Jörres R, et al.: The effect of 1 ppm nitrogen dioxide on bronchoalveolar lavage cells in normal and asthmatic subjects. Eur Respir J 8 (1995) 416–424PubMedCrossRefGoogle Scholar
  14. Jörres R, et al.: The effect of ozone exposure on allergen responsiveness in subjects with asthma or rhinitis. Accepted for publication in: Am J Respir Crit Care Med, 1995aGoogle Scholar
  15. Kleinman MT, et al.: Effect of 0.2 ppm nitrogen dioxide on pulmonary function and response to bronchoprovocation in asthmatics. J Toxicol Environ Health 12 (1983) 815–826PubMedCrossRefGoogle Scholar
  16. Kreit JW, et al.: Ozone-induced chances in pulmonary function and bronchial responsiveness in asthmatics. J Appl Physiol 66 (1989) 217–222PubMedGoogle Scholar
  17. Lebowitz MD, et al.: Time series analyses of respiratory responses to indoor and outdoor environmental phenomena. Environ Res 43 (1987) 332–341PubMedCrossRefGoogle Scholar
  18. Linn WS, et al.: Respiratory effects of sulfur dioxide in heavily exercising asthmatics. A dose-response study. Am Rev Respir Dis 127 (1983) 278–283PubMedGoogle Scholar
  19. Lioy PJ, et al.: Persistence of peak flow decrement in children following ozone exposures exceeding the National Ambient Air Quality Standard. J Air Pollut Control Assoc. 35 (1985) 1068–1071Google Scholar
  20. Magnussen H, et al.: Relationship between the airway response to inhaled sulfur dioxide, isocapnic hyperventilation and histamine in asthmatic subjects. Int Arch Occup Environ Health 62 (1990) 485–491PubMedCrossRefGoogle Scholar
  21. Magnussen H, et al.: Effect of air pollution on the prevalence of asthma and allergy: lessons from the German reunification. Thorax 48 (1993) 879–881PubMedCrossRefGoogle Scholar
  22. Mohsenin V: Airway responses to 2.0 ppm nitrogen dioxide in normal subjects. Arch Environ Health 43 (1988) 242–246PubMedCrossRefGoogle Scholar
  23. Molfino NA, et al.: Effect of low concentrations of ozone on inhaled allergen responses in asthmatic subjects. Lancet 338 (1991) 199–203PubMedCrossRefGoogle Scholar
  24. Nowak D, et al.: Bias due to non-responding in an epidemiological survey: questionnaire and measurements. Am Rev Respir Dis 145 (1992) A298 (abstract)Google Scholar
  25. Nowak D, et al.: Prevalence and risk factors for airway responsiveness to inhaled sulphur dioxide in an adult population sample. Am J Respir Crit Care Med 151 (1995) A282 (abstract)Google Scholar
  26. Peden DB, et al.: Ozone exposure has both a priming effect on allergeninduced responses and an intrinsic inflammatory action in the nasal airways of perennially allercic asthmatics. Am J Respir Crit Care Med 151 (1995) 1336–1345PubMedGoogle Scholar
  27. Rubinstein I, et al.: Short-term exposure to 0.3 ppm nitrogen dioxide does not potentiate airway responsiveness to sulfur dioxide in asthmatic subjects. Am Rev Respir Dis 141 (1990) 381–385PubMedGoogle Scholar
  28. Sheppard D, et al.: Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis 123 (1981) 486–491PubMedGoogle Scholar
  29. Sheppard D, et al.: Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Environ Res 30 (1983) 412–419PubMedCrossRefGoogle Scholar
  30. Sunyer J, et al.: Air pollution and emergency room admissions for chronic obstructive pulmonary disease: A 5-year study. Am J Epidemiol 137 (1993) 701–705PubMedGoogle Scholar
  31. Tunnicliffe WS, et al.: Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients. Lancet 344 (1994) 1733–1736PubMedCrossRefGoogle Scholar
  32. Walters S, et al.: Temporal association between hospital admissions for asthma in Birmingham and ambient levels of sulphur dioxide and smoke. Thorax 49 (1994) 133–140PubMedCrossRefGoogle Scholar
  33. Weymer AR, et al.: Pre-exposure to ozone does not enhance or produce exercise-induced asthma. Am J Respir Crit Care Med 149 (1994) 1413–1419PubMedGoogle Scholar
  34. Wichmann HE, et al.: Health effects during a smog episode in West-Germany in 1985. Environ Health Perspect 79 (1989)89–99PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • H. Magnussen
  • R. A. Jörres

There are no affiliations available

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