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Ionic Regulation in Animals: A Tribute to Professor W.T.W.Potts pp 33–49Cite as

Regulating the Micro-environment of Ion Transporting Epithelia: A Comparative Approach

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Abstract

Epithelia, epidermal or otherwise, that transport significant quantities of ions share a range of common characteristics. They include the presence of polarised surface cells, often with numerous mitochondria, a range of ion pumps and channels and a complex surface architecture. Almost universally research into functional morphology of epithelia concentrates on the cells themselves and rarely delves into the external space that borders the cell’s apical surface. This space is the surface’s micro-environment and the physical and chemical conditions that prevail within it can be described as its micro-climate.

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References

  • Adler, K.B., Holden-Stauffer, W.J. & Repine, J.E. 1990. Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism. J. Clin. Invest. 85: 75–85.

    Article  PubMed  CAS  Google Scholar 

  • Ahuja, S.K. 1970. Chloride cell and mucous cell response to chloride and sulphated enriched media in the gills of Cambusia affines and Catla cata. J. exp. Biol. 173: 231–50.

    CAS  Google Scholar 

  • Al-Bazzaz, F.J. 1994. regulation of Na and CI transport in sheep distal airways. Am. J. Physiol. 267: L193–L198.

    PubMed  CAS  Google Scholar 

  • Barbet, J.P., Chauveau, M., Labbe, S. & Lockhart, A. 1988. Breathing dry air causes acute epithelial damage and inflammation of the guinea pig trachea. J. Appl. Physiol. 64: 1851–1857.

    PubMed  CAS  Google Scholar 

  • Balm, P.H.M., Vanlieshout, E., Lokate, J. & Bonga, S.E.W. 1995. Bacterial lipopolysaccharide (LPS) and interleukin 1 (IL-1) exert multiple physiological effects in the Tilapia oreochromis mossambicus (Teleostei). J. Comp. Physiol. - B, Biochemical, Systemic & Environmental Physiology, 165(2): 85–92.

    Article  CAS  Google Scholar 

  • Barnett, R.R., Akindele, T., Orte, C. & Shephard, K.L. 1996. Eosinophilic granulocytes in the epidermis of tilapia (Oreochromis mossambicus) gill filaments studied in situ. J. Fish Biol, (in press).

    Google Scholar 

  • Blackstock, N. & Pickering, A.D. 1982. Changes in the concentration and histochemistry of epidermal mucous cells during the alevin and fry stages of the brown trout, Salmo trutta. J. Zool. Lond. 197: 463–471.

    Google Scholar 

  • Boucher, R.C., Stutts, M.F., Knowles, R.C., Cantley, L. & Gatzy, J.T. 1986. Na transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J. Clin. Invest. 78: 1245–1252.

    CAS  Google Scholar 

  • Bouhanna, C., Berthon, B., Combettes, L., Claret, M. & Laboisse, C.L. 1994. Role of calcium in carbachol- and neurotensin-induced mucin exocytosis in a human colonic goblet cell line and cross-talk with the cyclic AMP pathway.

    Google Scholar 

  • Breckenridge, L.J. & Almers, W. 1987. Final steps in exocytosis observed in cells with giant secretory granules. Proc. Natl. Acad. Sei. USA 84: 1945–9.

    Article  CAS  Google Scholar 

  • Burden, C.E. 1956. The failure of hypophysectomized Fundulus heteroclitus to survive in freshwater. Biol. Bull. mar. biol. Lat. Woods Hole 110: 8–28.

    Article  CAS  Google Scholar 

  • Burnstock, G. 1986a. Purines as cotransmitters in adrenergic and cholinergic neurones. Prog. Brain Res. 68: 193–203.

    Article  PubMed  CAS  Google Scholar 

  • Burnstock, G. 1986b. The non-adrenergic non-cholinergic nervous system. Arch. Int. Pharmacodyn Terh. 280, 1–15.

    CAS  Google Scholar 

  • Burton, D. & Everard, B.A. 1991. The effect of androgen treatment on the epidermis of post-spawned winter flounder Pseudopleuronectes americanus (Walbaum). J. Fish Biol. 38: 73–80.

    Article  Google Scholar 

  • Carlstedt, I. & Sheehan, J.K. 1989. Structure and macromolecular properties of cervical mucus glycoproteins. Symp. Soc. Exp. Biol. 43: 289–316.

    PubMed  CAS  Google Scholar 

  • Cole, P. 1982. Modification of inspired air. In: The Nose, edited by D.F. Proctor & I.B. Anderson, Amsterdam: Elsevier: 351–376.

    Google Scholar 

  • Davis, C.W., Dowell, M.L., Lethem, M. & Van Scott, M. 1992. Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP, ADP, and adenosine. Am. J. Physiol 262 (Cell Physiol. 31): C1313–C1323.

    Google Scholar 

  • Daviskas, E., Gonda, I. & Anderson, S.D. 1991. Local airway heat and water vapour losses. Respir. Physiol. 84: 115–132.

    Article  PubMed  CAS  Google Scholar 

  • De Ruiter, A.J.H. & Mein, C.G. 1982. Testosterone-dependent transformation of nephronic tubule cells into serous and mucous gland cells in stickleback kidneys in vivo and in vitro. Gen. comp. Endocrinol. 47: 70–83.

    Article  PubMed  Google Scholar 

  • Deyrup-Olsen, I., Luchtel, D.L. & Martin, A.W. 1983. Components of mucus of terrestrial slugs (Gastropoda). Am. J. Physiol. 245: R448–R452.

    PubMed  CAS  Google Scholar 

  • Fernandez, J.M., Villalon, M. & Verdugo, P. 1991. Reversible condensation of mast cell secretory products in vitro. Biophys. J. 59: 1022–7.

    Article  PubMed  CAS  Google Scholar 

  • Fletcher, T.C. & White, A. 1973. Lysozyme activity in the plaice (Pleuronectes platessa). Experientia 29: 1283–5.

    Article  PubMed  CAS  Google Scholar 

  • Frizzel, R.A. 1988. Role of absorptive, and secretory processes in hydration of the irway surface. Am. Rev. Respir. Dis. Suppl. 138: S3–S6.

    Google Scholar 

  • Handy, R.D. & Eddy, F.B. 1991. The absence of mucus on the secondary lamellae of unstressed rainbow trout, Oncorhyncus mykiss (Walbaum). J. Fish Biol. 38: 153–5.

    Article  Google Scholar 

  • Hayden, U.L. & Carey, H.V. 1996. Cellular localisation of cystic fibrosis transmembrane regulator protein in pigment and mouse intestine. Cell & Tiss. Res. 283(2): 209–213.

    Article  CAS  Google Scholar 

  • Hayes, J.P., Kuo, H.P., Rohde, J.A.L., Taylor, A.J.N., Barnes, P.J., Chung, K.F. & Rogers, D.F. 1995. Neurogenic goblet cell secretion and bronchoconstriction in guinea pigs sensitised to trimellitic anhydride. Eur. J. Pharmacol. 292(2): 127–134.

    PubMed  CAS  Google Scholar 

  • Helfferich, F. 1962. Ion exchange. New York: McGraw-Hill, 482pp.

    Google Scholar 

  • Hoffstein, S.T., Malo, P.E., Bugelski, P. & Wheeldon, E.B. 1990. Leukotriene D4 (LTD4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium. Exp. Lung Res. 16: 711–725.

    Article  PubMed  CAS  Google Scholar 

  • Hootman, S.R. & Deondarza, J. 1995. Regulation of goblet cell degranulation in isolated pancreatic ducts. Am. J. Physiol. 31(1): G24-G.

    Google Scholar 

  • Hughes, G.M. & Wright, D.E. 1970. A comparative study of the ultrastructure of the water-blood pathway in the secondary lamellae of teleost and elasmobranch fishes - benthic forms. Z. Zellforsch. mikrosk. Anat. 104: 478–93.

    Article  PubMed  CAS  Google Scholar 

  • Iger, Y., Balm, P.H.M. & Bonga, S.E.W. 1994. Cellular responses of the skin and changes in plasma Cortisol levels of trout (Oncorhynchus mykiss) exposed to acidified water. Cell & Tissue Res. 278(3): 535–542.

    Article  CAS  Google Scholar 

  • Iger, Y., Balm, P.H.M., Jenner, H.A. & Bonga, S.E.W. 1995. Cortisol induces stress-related changes in the skin of Rainbow trout (Oncorhynchus mykiss). Gen. & Comp. End. 97(2): 188–198.

    Article  CAS  Google Scholar 

  • Kapeleta, M.V., Jimenez-Mallebrera, C., Carnicer-Rodriguez, M.J., Cook. A. & Shephard, K.L. 1996. Production of mucous granules by the terrestrial slug Arion ater L. J. Moll. Stud. 62: 251–256.

    Article  Google Scholar 

  • Kilburn, K.H. 1968. A hypothesis for pulmonary clearance and its implications. Am. rev. Respir. Dis. 98: 449–463.

    PubMed  CAS  Google Scholar 

  • Klinger, J.D., Tandler, B., Liedtke, C.M. & Boat, T.F. 1984. Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium. J. Clin. Invest. 74: 1669–1678.

    Article  PubMed  CAS  Google Scholar 

  • Laurent, P. 1984. Gill internal morphology. In: Hoar, W.S. & Randall, D.J., eds. Fish Physiology, Vol. XA. Orlando FL: Academic Press: 73–183.

    Google Scholar 

  • Maggi, C.A. & Mell, A. 1987. The sensory-efferent function of capsaicin- sensitive sensory neurones. Gen. Pharmacol. 19: 1–43.

    Google Scholar 

  • Man, S.F.P., Adams III, G.K. & Proctor, D.F. 1979. Effects of temperature, relative humidity, and mode of breathing on canine airway secretions. J. Appl. Physiol. 46: 205–210.

    PubMed  CAS  Google Scholar 

  • Marshall, W.S. 1976. Effects of hypophysectomy and ovine prolactin on the epithelial mucus secreting cells of the pacific staghorn sculpin Leptocottus armatus (Teleostei: Cottidae). Can. J. Zool. 54: 1604–9.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, W.S. 1979. Effects of salinity acclimation, prolactin, growth hormone and Cortisol on the mucous cells of Leptocottus armatus (Teleostei: Cottidae). Gen. comp. Endocrinol. 37: 358–68.

    Article  PubMed  CAS  Google Scholar 

  • Martin, A.W. & Deyrup-Olsen, I. 1986. Function of the epithelial channel cells of the body wall of a terrestrial slug, Ariolimax columbianus. J. Exp. Biol. 121: 301–314.

    CAS  Google Scholar 

  • Mattheij, J.A.M. & Stroband, H.W.J. 1971. The effects of osmotic experiments and prolactin on the mucous cells in the skin and the ionocytes in the gills of the teleost Chichlasoma biocellatum. Z. Zellforsch 121: 93–101.

    Article  PubMed  CAS  Google Scholar 

  • McCahon, C.P., Pascoe, D. & McKavanagh, C. 1987. Histochemical observations on the salmonids Salmo salar L. and Salmo trutta L. and the ephemeropterans Baetis rhodani (Pict.) and Ecdyonurus venosus (Fabr.) following a simulated episode of acidity in an upland stream. Hydrobiologia 153: 3–12.

    Article  CAS  Google Scholar 

  • McDonald, D.G. & Wood, C.M. 1993. Branchial mechanisms of acclimation to metals in freshwater fish. In. Rankin, J.C. & Jensen, F.B. (eds.). Fish ecophysiology, Chapman & Hall, London.

    Google Scholar 

  • McDonald, D.G., Wood, C.M., Rhem, R.G., Mueller, M.E., Mount, D.R. and Bergman, H.L. 1991b. Nature and time course of acclimation to aluminium in juvenile brook trout (Salvelinus fontinalis). J. Physiology. Can. J. Fish aquat. Sci., 48, 2006–15.

    Article  CAS  Google Scholar 

  • McFadden, E.R. 1983. Respiratory heat and water exchange: physiological and clinical implications. J. Appl. Physiol. 54: 331–336.

    PubMed  Google Scholar 

  • McFadden, E.R., Pichurko, B.M., Bowman, H.F., Ingenito, E., Burns, S., Dowling, N. & Solway, J. 1985. Thermal mapping of the airways in humans. J. Appl. Physiol. 58: 564–570.

    Article  PubMed  Google Scholar 

  • Merlin, D., Augeron, C., Tien, X.Y., Guo, X., Laboisse, C.L. & Hopfer, U. 1994. ATP-stimulated electrolyte and mucin secretion in the human intestinal goblet cell line HT29-CL.16E. J. Membrane Biol. 137(2): 137–149.

    Article  CAS  Google Scholar 

  • Mills, C.L., Dorin, J.R., Davidson, D.J., Porteus, D.J., Alton, E.W.F.W., Dormer, R.L. and McPherson, M.A. 1995. Decreased beta-adrenergic stimulation of glycoprotein secretion in CF mice submandibular glands - reversal by the methylxanthine, IBMX. Bioch. & Biophys. Res. Comm. 215(2): 674–681.

    Article  CAS  Google Scholar 

  • Mittal, A.K., Fujimori, O., Ueda, H. & Yamada, K. 1995. Carbohydrates in the epidermal mucous cells of a freshwater fish Mastacembelus pancalus (Mastacembelidae, Pisces) as studied by electron-microscopic sytochemical methods. Cell Tissue Res. 280: 531–539.

    Article  CAS  Google Scholar 

  • Monck, J.R., Oberhauser, A.F., Alvarez de Toledo, G. & Fernandez, J.M. 1991. Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore? Biophys. J. 59: 39–47.

    Article  PubMed  CAS  Google Scholar 

  • Muniz, LP. & Leivestad, H. 1980. Toxic effects of aluminium on the brown trout, Salmo trutta L. In: Drablos, D. & Tollan, A., eds. Ecological Impact of Acid Precipitation. Oslo, Norway, SNSF project: 320–21.

    Google Scholar 

  • Nathanson, I., Widdicombe, J.H. & Nadel, J.A. 1983. Effects of amphotericin B on ion and fluid movement across dog tracheal epithelium. J. Appl. Physiol. 55: 1257–1261.

    PubMed  CAS  Google Scholar 

  • Nicholl, C.S. & Bern, H.A. 1971. On the actions of prolactin among the vertebrates: is there a common denominator? In: Wolstenholme, G.E.W. & Knight, J. (eds.) Ciba Foundation Symposium on Lactogenic Hormones. London: Churchill-Livingstone: 299–324.

    Google Scholar 

  • Nilsson, S. 1984. Innervation and pharmacology of the gills. In Fish Physiology, Vol. XA (eds. W.S. Hoar & D.J. Randall), Academic Press, Orlando, FL: 185–227.

    Google Scholar 

  • Ogawa, M. 1970. Effects of prolactin on the epidermal mucous cells of the goldfish, Carassius auratus L. Can. J. Zool. 48: 501–3.

    Article  PubMed  CAS  Google Scholar 

  • O’Grady, P. 1991. Pharmacology and therapeutic applications of the quinoline antibiotic flumequine in salmonid fish. PhD thesis, University College, Galway, National University of Ireland.

    Google Scholar 

  • Ojha, J. & Munshi, J.S.D. 1974. Histochemical and histophysiological observations on specialised branchial glands of a freshwater mud-eel Macrognathus aculeatum (Bloch) (Mastacembelidae: Pisces). Mikroskopie 30: 1–16.

    PubMed  CAS  Google Scholar 

  • Olivereau, M. & Lemoine, A.M. 1971. Action de la prolactire cheq l’anguille intacte et hypophysecsomisee. Z. vergl. Physiol. 73: 34–43.

    Article  Google Scholar 

  • Olver, R.E., Davis, B., Marin, M.G. & Nadel, J.A. 1975. Active transport of Na+ and CI- across the canine tracheal epithelium in vivo. Am. Rev. Respir. Dis. 112: 811–815.

    PubMed  CAS  Google Scholar 

  • Peatfield, A.C. & Richardson, P.S. 1983. Evidence for non-cholinergic, non- adrenergic nervous control of mucus secretion into the cat trachea. J. Physiol. 342: 335–345.

    PubMed  CAS  Google Scholar 

  • Pickering, A.D. 1976. Synthesis of an acetyle neuraminic acid from 14C glucose by the epidermis of the brown trout, Salmo trutta L. Comp. Biochem. Physiol. 54B: 325–8.

    Google Scholar 

  • Pickering, A.D. & Macey, D.J. 1977. Structure histochemistry and the effect of handling on the mucous cells of the epidermis of the char Salvelinus alpinus (L.). J. Fish Biol. 10: 505–12.

    Article  Google Scholar 

  • Pickering, A.D. & Richards, R.H. 1980. Factors influencing the structure, function and biota of the salmonid epidermis. Proc. R. Soc. Edin. 79B: 93–104.

    Google Scholar 

  • Powell, M.D., Wright, G.M. & Burka, J.F. 1990. Eosinophilic granule cells in the gills of rainbow trout, Oncorhynchus mykiss: evidence of migration? J. Fish Biol. 37: 495–497.

    Article  Google Scholar 

  • Rahmoune, H. & Shephard, K. 1994. Regulation of airway surface liquid on the isolated guinea pig trachea. Pulmonary Pharmacology 7: 265–269.

    Article  PubMed  CAS  Google Scholar 

  • Rahmoune, H. & Shephard, K. 1995. State of airway surface liquid on guinea pig trachea. J. Appl. Physiol. 78(6): 2020–2024.

    PubMed  CAS  Google Scholar 

  • Rammarine, S.I., Hirayama, Y., Barnes, P.J. & Rogers, D.F. 1994. ’Sensory- efferent’ neural control of mucus secretion: characterisation using tachykinin receptor antagonists in ferret trachea in vitro. Brit. J. Pharmacol. 113: 1183–1190.

    Google Scholar 

  • Raphael, G.D., Meredith, S.D., Baraniuk, H.N., Druce, H.M., Banks, S.M. & Kaliner, M.A. 1989. The pathophysiology of rhinitis. II. Assessment of he sources of protein in histamine induced nasal secretions. Am. Rev. Respir, Dis. 139: 791–800.

    CAS  Google Scholar 

  • Riordan, J.R. 1993. The cystic fibrosis transmembrane conductance regulator. Annu. Rev. Physiol. 55: 609–30.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, R.J. & Bullock, A.M. 1980. The skin surface ecosystem of teleost fishes. Proc. R. Soc. Edinb. u: 87–91.

    Google Scholar 

  • Rogers, D.F. 1994. Airway goblet cells - responsive and adaptable front-line defenders. European Resp. J. 7(9): 1690–1706.

    Article  CAS  Google Scholar 

  • Rogers, D.F. 1995. Neurokinin receptors subserving airways secretion. Can. J. Physiol. & Pharmacol. 73(7): 932–939.

    Article  CAS  Google Scholar 

  • Shephard, K.L. 1987a. Ion-exchange phenomena regulate the environment of embryos in the eggs of freshwater fish. Comp. Biochem. Physiol. 88A: 659–62.

    Article  CAS  Google Scholar 

  • Shephard, K.L. 1987b. The influence of water pH on the perivitelline fluid of perch (Perca fluviatilis) eggs. Comp. Biochem. Physiol. 86C: 383–6.

    Google Scholar 

  • Shephard, K.L. 1992a. Studies on the fish-gill microclimate: interactions between gill tissue, mucus and water quality. Env. Biol. Fishes 34: 409–20.

    Article  Google Scholar 

  • Shephard, K.L. 1992b. Studies on the fish-gill microclimate. J. comp. Physiol. 162B: 231–40.

    Google Scholar 

  • Shephard, K.L. 1994. Functions for fish mucus. Rev. Fish Biol & Fisheries 4: 401–429.

    Article  Google Scholar 

  • Shephard, K.L. & Rahmoune, H. 1994. Evaporation-induced changes in airway surface liquid on an isolated guinea pig trachea. J. Appl. Physiol. 76(3): 1156–1165.

    PubMed  CAS  Google Scholar 

  • Stuart, T.A. 1953. Spawning migration reproduction and young stages of loch trout (Salmo trutta L.). Freshwat. Salm. Fish Res. 5: 1–39.

    Google Scholar 

  • Tanaka, T. 1981. Gels. Sci. Am. 244: 124–38.

    CAS  Google Scholar 

  • Tanaka, Y., Yoshida, Y. & Hirano, M. 1995. Precise localisation of VIP-, NPY- and TH-immunoreactivities of cat laryngeal glands. Brain Res. Bull. 36(3): 219–224.

    CAS  Google Scholar 

  • Uvnas, B. & Aborg, C.H. 1977. On the cation exchanger properties or rat mast cell granule and their storage of histamine. Acta. Physiol. Scand. 100: 309–14.

    Article  PubMed  CAS  Google Scholar 

  • Verburgvankemenade, B.M., Weyts, F.A.A., Debets, R. & Flik, G. 1995. Carp macrophages and neutrophilic granulocytes secrete an interleukin-l-like factor. Dev. & Comp. Imm. 19(1): 59–70.

    Article  CAS  Google Scholar 

  • Verdugo, P. 1990. Goblet cell secretion. Ann. Rev. Physiol. 52: 157–176.

    Article  CAS  Google Scholar 

  • Verdugo, P. 1991. Mucus exocytosis. Am. Rev. of Resp. Dis. 144: S33–S37.

    CAS  Google Scholar 

  • Virabhadrachari, V. 1961. Structural changes in the gills intestine and kidney of Etroplus maculatus (Teleostei) adapted to different salinities. Q. J. microsc. Sci. 102: 361–9.

    Google Scholar 

  • Welsh, M.J., Widdicombe, J.H. & Nadel, J.A. 1980. Fluid transport across the canine tracheal epithelium. J. Appl. Physiol. 49: 905–909.

    PubMed  CAS  Google Scholar 

  • Wendelaar Bonga, S.E. 1978. The effects of changes in external sodium, calcium and magnesium concentrations on prolactin cells, skin and plasma electrolytes of Gasterosteus aculeatus. Gen. comp. Endocrinol. 34: 265–75.

    Article  CAS  Google Scholar 

  • Wendelaar Bonga, S.E. & Meis, S. 1981. Effects of external osmolarity, calcium and prolactin on growth and differentiation of the epidermal cells of the cichlid teleost, Sarotherodon mossambicus. Cell Tiss. Res. 221: 109–23.

    Article  CAS  Google Scholar 

  • Westfall, B.A. 1945. Coagulation film anoxia in fishes. Ecology 26: 283–7.

    Article  CAS  Google Scholar 

  • Whitear, M. 1986. The skin of fishes including cyclostomes. In: Bereiter-Hahn, J., Matottsy, A.G. & Richards, K.S., eds. Biology of the Integument, Vol. 2. Berlin: Springer, pp. 8–64.

    Google Scholar 

  • Whitear, M. 1970. The skin surface of bony fishes. J. Zool., Lond. 160: 437–54.

    Article  Google Scholar 

  • Widdicombe, J.H., Welsh, M.J. & Finkbeiner, W.E. 1985. Cystic fibrosis decreases the apical membrane chloride permeability of monolayers cultured from cells of tracheal epithelium. Proc. Nat. Acad. Sci. USA 82: 6167–6171.

    Article  PubMed  CAS  Google Scholar 

  • Widdicombe, J.H. & Widdicombe, J.G. 1995. Regulation of human airway surface liquid. Resp. Physiol. 99: 3–12.

    Article  CAS  Google Scholar 

  • Zaccone, G. 1981. Effect of osmotic stress on the chloride and mucous cells in the gill epithelium of the freshwater teleost, Barbus filamentosus (Cypiriniformes, Pisces). A structural and histochemical study. Acta Histochem. 68: 147–159.

    CAS  Google Scholar 

  • Zhang, Y.L., Doranz, B., Yankaskas, J.R. & Engelhardt, J.F. 1995. Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis. J. Clin. Inv. 96(6): 2997–3004.

    Article  CAS  Google Scholar 

  • Zimmerberg, J., Curran, M., Cohen, F.S. & Brodwick, M. 1987. Simultaneous electrical and optical measurements show that membrane fusion precedes secretory granule during exocytosis of beige mouse mast cells. Proc. Nat. Acad. Sci. USA 84: 1585–9.

    Article  PubMed  CAS  Google Scholar 

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  1. K. L. Shephard

    Present address: LSU, Southampton, S017 1BG, UK

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  1. The Clore Laboratory for Life Sciences, The University of Buckingham, Buckingham, Bucks, MK18 1EG, UK

    K. L. Shephard

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  1. Gatty Marine Laboratory, University of St. Andrews, KY16 8LB, St. Andrews, Fife, Scotland, UK

    Neil Hazon

  2. Department of Biological Sciences, University of Dundee, DD1 4HN, Dundee, Scotland, UK

    F. Brian Eddy

  3. Department of Animal Physiology, University of Nijmegen, 6525 ED, Nijmegen, The Netherlands

    Gert Flik

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Shephard, K.L. (1997). Regulating the Micro-environment of Ion Transporting Epithelia: A Comparative Approach. In: Hazon, N., Eddy, F.B., Flik, G. (eds) Ionic Regulation in Animals: A Tribute to Professor W.T.W.Potts. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60415-7_3

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