Teleost renal function:regulation by arginine vasotocin and by angiotensins

  • J. A. Brown
  • R. J. Balment
Conference paper

Abstract

Euryhaline teleosts are able to live in or adapt to a wide range of environmental salinities and maintain relatively constant plasma osmolality. Adaptive changes in renal function play an important part in this euryhalinity (along with changes in gill and gut transport). In dilute media, high rates of urine output eliminate the osmotic influx of water at the gills, whereas in media more concentrated than plasma, urine flow rates are generally reduced, reflecting reduced glomerular filtration rates (Rankin, Henderson & Brown, 1983). Physiological control of these changes in renal function is poorly understood but is likely to involve endocrine and paracrine factors/systems. The recently described atrial natriuretic peptides (Takei, 1994) have been reported to be diuretic and natriuretic in rainbow trout and toadfish (Duff & Olson, 1986; Lee & Malvin, 1987). However, the physiological significance of these observations awaits clarification as these studies employed heterologous peptides and it is unclear how the doses employed relate to the recent first description of circulating levels of these peptides in the Japanese eel (Kaiya & Takei, 1996). The pituitary hormones, arginine vasotocin (AVT) or isotocin and the renin-angiotensin system (acting through the active angiotensin peptides) have long been implicated in the adaptive regulation of teleost kidney function, though this lacks clear definition. Investigation of the circumstances in which release of these hormones is initiated or in which local systems are activated is of importance in understanding their involvement in control of physiological function. A multiplicity of approaches has been applied in recent years from which we are beginning to gain insights into the role that AVT and angiotensins play in the control of renal function in fish.

Keywords

Permeability Adenosine Acid Number Arginine Angiotensin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. A. Brown
    • 1
  • R. J. Balment
    • 2
  1. 1.Department of Biological SciencesUniversity of ExeterExeterUK
  2. 2.School of Biological SciencesUniversity of ManchesterManchesterUK

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