Abstract
Various structural rearrangements on the short arm of chromosome 6 have been repeatedly reported in therapy-related hematological malignancies, but very rarely as solitary anomaly. Here we report a case of acute nonlymphocytic leukemia (ANLL) after radiochemotherapy for Hodgkin’s disease, with a deletion of chromosome 6 (p21pter). This is the first case of deletion 6p as a solitary chromosomal anormaly reported in therapy-related ANLL. This case strongly supports the nonrandom involvement of chromosome 6p in induced leukemias.
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© 1997 Springer-Verlag Berlin Heidelberg
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Metzke, S., Herold, M., Anger, G., Claussen, U. (1997). Deletion of Chromosome 6p as Primary Karyotypic Anomaly in Secondary Acute Nonlymphocytic Leukemia. In: Büchner, T., Schellong, G., Ritter, J., Creutzig, U., Hiddemann, W., Wörmann, B. (eds) Acute Leukemias VI. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60377-8_5
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DOI: https://doi.org/10.1007/978-3-642-60377-8_5
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