Detection of Minimal Tumor Cell Populations by FICTION
Sensitive techniques for the detection of minimal tumor cell populations are gaining in importance. In hematological disorders they are required for monitoring residual disease after therapy, detection of minimal bone marrow infiltration by malignant lymphoma cells and exclusion of tumor cell contamination after leukapheresis. The applicability of the combination of immunophenotyping and interphase cytogenetics, the FICTION technique, to detection of minimal tumor cell populations is demonstrated in a case of Hodgkin’s disease.
KeywordsMinimal Residual Disease Chromosome Aberration Acute Lymphatic Leukemia Cytospin Slide Mosome Aberration
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