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Safrole – Sassafras Albidum

Chapter
Part of the Adverse Effects of Herbal Drugs book series (HERBAL DRUGS, volume 3)

Abstract

Sassafras albidum (Nutt.) Nees (syn. Sassafras officinale Nees et Eberm.; Sassafras variifolium (Salisb.) Kuntze) belongs to the Lauraceae. Vernacular names include sassafras, saxifrax, ague tree, cinnamon wood, saloop (E.); Fenchelholz (G.); and Bois de Sassafras (F.) [1,2]. Sassafras is native to North America and China [3]. The root with or without bark and the volatile oil are used medicinally [1,2,4]. Because of their sassafras–like odor, which is presumably due to the content of safrole, the following herbal drugs are also called “sassafras”: Atherosperma moschatum Labill. (Australian sassafras), Mespilodaphne sassafras Meister (Brazilian sassafras), and Doryphora sassafras Endl. (New Caledonian sassafras). Brazilian sassafras oil is obtained from Ocotea pretiosa (Nees.) Mez. [4].

Keywords

Fibrous Histiocytoma Root Bark Mycobacterium Smegmatis Hydrobromic Acid Sassafras Albidum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Windholz M (ed) (1983) The Merck Index. 10th Edition. Rahway, NJ: Merck & Co.Google Scholar
  2. 2.
    List PH, Hörhammer L (1979) Hagers Handbuch der Pharmazeutischen Praxis. Vollständige (vierte) Neuausgabe. Sechster Band. Chemikalien und Drogen (R,S) Berlin: Springer-VerlagGoogle Scholar
  3. 3.
    Mitchell J, Rook A (1979) Botanical dermatology. Plants and plant products injurious to the skin. Greengrass: Vancouver, p. 377Google Scholar
  4. 4.
    Hoppe HA (1975) Drogenkunde. Band 1. Angiospermen. 8. Auflage. Berlin: Walter de GruyterGoogle Scholar
  5. 5.
    Sehti ML, Rao GS, Chowdhury BK, Morton JF, Kapadia GJ (1976) Identification of volatile constituents of Sassafras albidum root oil. Phytochemistry 15:1773–1775CrossRefGoogle Scholar
  6. 6.
    Noggle FT, Clark CR, De Ruiter J (1991) Gas Chromatographie and mass spectrometric analysis of samples from a elandestine laboratory involved in the synthesis of ecstacy from sassafras oil. J Chromatogr Sci 29:168–173Google Scholar
  7. 7.
    Noggle FT, Clark CR, De Ruiter J (1991) Gas Chromatographie and mass spectrometric analysis of N-Methyl-l-aryl-2-propanamines synthesized from the substituted allylbenzenes present in sassafras oil. J Chromatogr Sci 29:267–271Google Scholar
  8. 8.
    Chowdhury BK, Sehti ML, Lloyd HA, Kapadia GJ (1976) Aporphine and tetrahydrobenzylisoquinoline alkaloids in Sassafras albidum. Phytochemistry 15:1803–1804CrossRefGoogle Scholar
  9. 9.
    Höke M, Hänsel R (1972) Eine Neuuntersuchung des Lignum Sassafras. Arch Pharm 305:33–39CrossRefGoogle Scholar
  10. 10.
    Sultatos LG (1986) Occurrence of the carcinogen safrole in the food additive file. Fed Proc 45:343Google Scholar
  11. 11.
    Gemballa G (1958) Scientia Pharmaceutica pp.8–14Google Scholar
  12. 12.
    Gershbein LL (1977) Regeneration of rat liver in the presence of essential oils and their components. Fd Cosmet Toxicol 15:173–181CrossRefGoogle Scholar
  13. 13.
    Segelman AB, Segelman FP, Karliner J, Sofia RD (1976) Sassafras and Herb Tea. Potential Health Hazards. JAMA 236:477PubMedCrossRefGoogle Scholar
  14. 14.
    Chaumont JP, Bardey I (1989) In-Vitro Antifungal Activity of Seven Essential Oils. Fitoterapia 60:263–266Google Scholar
  15. 15.
    El-Feraly FS, Cheatham SF, Breedlove RL (1983) Antimicrobial neolignans of Sassafras randaiense roots. J Nat Prod 46:493–498CrossRefGoogle Scholar
  16. 16.
    Moreno OM (1976) Report to RIFM, 7 September; cited in 11Google Scholar
  17. 17.
    Opdyke DLJ, Letizia C (1982) Monographs on fragrance raw materials: Sassafras Oil. Fd Cosmet Toxicol 20:825–826Google Scholar
  18. 18.
    Anonymous (1974) Natural Flavouring Substances. Their Sources, and Added Artificial Flavouring Substances. Council of Europe, Partial Agreement in the Social and Public Health Field. List N(2), no. 424. StrasbourgGoogle Scholar
  19. 19.
    Anonymus (1993) Report on the Operation of the Committee for Proprietary Medicinal Products in 1991 and 1992. Brussels: Commission of the European Communities, p. 49Google Scholar
  20. 20.
    De Smet PAGM (1994) Een alternatieve olie met een luchtje. Pharm Weekbl 129:258Google Scholar
  21. 21.
    Allbright M (1888) A case of poisoning by oil of sassafras. Cincinnati Lancet and Clinic 21:631–632Google Scholar
  22. 22.
    Jacobs MB (1958) Toxicity of Safrole. Am Perfum Aromat 71:57–58Google Scholar
  23. 23.
    Leidy WPh (1958) Safrole – a critical bibliographical review of available literature on the physiological effects of safrole. Am Perfum Aromat 71:61–63Google Scholar
  24. 24.
    Craig JO (1953) Poisoning by the volatile oils in childhood. Arch Dis Child 29:475–483CrossRefGoogle Scholar
  25. 25.
    Grande GA, Dannewitz SR (1987) Symptomatic Sassafras Oil Ingestion. Vet Hum Toxicol 29:147Google Scholar
  26. 26.
    Kläsi J, Roth O (1915) Über einen Fall von Safrolvergiftung. Monatsschr Psych Neurol 38:235–250CrossRefGoogle Scholar
  27. 27.
    Haines Jr JD (1991) Sassafras tea and diaphoresis. Postgraduate Medicine 90, no.4, 75–76Google Scholar
  28. 28.
    Tulipan L (1938) Cosmetic irritants. Arch Dermatol Syph 38:906–917Google Scholar
  29. 29.
    Kapadia GJ, Chung EB, Ghosh B, Shukla YN, Basak SP, Morton JF, Pradhan SN (1978) Carcinogenicity of some folk medicinal herbs in rats. J Natl Cancer Inst 60:683–686PubMedGoogle Scholar
  30. 30.
    Abbott DD, Packman EW, Wagner BM, Harrisson JWE (1961) Chronic oral toxicity of oil of sassafras and safrole. Pharmacologist 3:62Google Scholar

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© Springer-Verlag Berlin Heidelberg 1997

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