Genetically Modified Fibroblasts Induce Angiogenesis in the Rat Epigastric Island Flap

  • H.-G. Machens
  • J. R. Morgan
  • F. Berthiaume
  • P. Stefanovich
  • A. C. Berger
Conference paper


One of the domains in the field of plastic and reconstructive surgery comprises the transposition or transplantation of tissue to cover defects due to different aetiopathological reasons. In all cases, however, sufficient blood supply to the tissue is mandatory to ensure complete survival of the transported tissue and a successful operation. For hundreds of years, surgeons have tried to support the formation of new blood vessels (i. e., angiogenesis) within the transported tissue (i.e., flap) by different means. Usually the flap was “conditioned” by raising the flap in its wound bed and suturing it back into its place, thus creating a slightly ischemic situation within the flap tissue by surgical division of the nutrient blood vessels except for the supporting vascular pedicle. After 2–3 weeks, the flap had developed enough new nutrient blood vessels on its own to survive after its transfer. This angiogenetic process was named “delay phenomenon.”


Vascular Pedicle Flap Survival Inferior Superficial Epigastric Artery Panniculus Carnosus Sufficient Blood Supply 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • H.-G. Machens
  • J. R. Morgan
  • F. Berthiaume
  • P. Stefanovich
  • A. C. Berger

There are no affiliations available

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