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Delivery Systems for Osteoinductive Proteins

Conference paper

Abstract

Bone morphogenetic proteins (BMPs) have been investigated for three decades. The fact that demineralized bone and extracts of demineralized bone are osteoinductive was first shown by Urist [1]. The temporal sequence of bone induction was described by Reddi and co-workers [2]. Of the various growth and differentiative factors known, only the native and recombinant BMPs have shown the ability to singularly induce de novo bone formation both in vitro and in vivo. Their principle function is to induce transformation of undifferentiated mesenchymal cells into chondroblasts and/or osteoblasts.

Keywords

Bone Morphogenetic Protein Fibrin Glue Collagen Matrix Glass Ceramic Collagen Sponge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • G. Hotz

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