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Matrix and Carrier Materials for Bone Growth Factors: State of the Art and Future Perspectives

  • D. Hutmacher
  • A. Kirsch
  • K. L. Ackermann
  • M. B. Hürzeler

Abstract

In reviewing the scientific literature of hard-tissue repair/generation, it can be concluded that it is worthwhile to evaluate the possibility of obtaining synergistic effects by combining bioresorbable scaffolds with other factors stimulatory to osteogenesis. Theoretically, this can occur at different principal levels. Cytokines, including growth factors such as BMP, the IGFs, TGF-b, PDGF, may be stimulatory to the differentiation of cells of the osteoblastic lineage, thus having the potential to promote an increased recruitment of osteogenic cells. The IGFs, TGF-b, and PDGF are known to stimulate the synthetic capacity of mature osteoblasts. In addition, the FGFs are angiogenic and may thus improve nutrition for a healing bone defect by an early establishment of the vascular bed. At present, the field of growth-stimulatory factors is strongly expanding. Even though the effects on bone of such factors are far from being completely elucidated, it may be expected that some of them will be of clinical relevance in the future. Future developments of de novo biodegradable and bioresorbable carrier and matrix materials treated with growth factors should have the objectives: biointeractive and biomi-metic devices/implants endowed with cell or cell-based signals; a synthetic extracellular matrix for enhanced cell interaction, cell polarization, or remodeling; and a temporal and/or spatial delivery of bioactive agents over short and long time-periods.

Keywords

Bone Morphogenetic Protein Carrier Material Absorbable Collagen Sponge Bioresorbable Scaffold Bone Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • D. Hutmacher
  • A. Kirsch
  • K. L. Ackermann
  • M. B. Hürzeler

There are no affiliations available

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