Zusammenfassung
Die zur Substitutionstherapie eingesetzten Antithrombinkonzentrate werden aus Humanplasma hergestellt. Seit Einführung des Begriffs Antithrombin wurde mehrere Male versucht, Antithrombin anzureichern, doch erst 1967 stellten Abildgaard und Heimburger zwei Methoden vor, die zu praktischen Ergebnissen führten [1, 2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abildgaard U (1967) Purification of two progressive antithrombins of human plasma. Scand J Clin Lab Invest 19:190
Heimburger N (1967) First Int Symp Tissue Factors in the Hemostasis of the Coagulation-Fibrinolysis System. Firenze, 353
Miller-Andersson M, Borg H, Andersson L-0 (1974) Purification of anti-thrombin III by affinity chromatography. Thromb Res 5:439
Abildgaard U (1978) Personal communication
Schramm W (1983) Erfahrungen mit der Substitution von Antithrombin-III-Konzentraten bei angeborenen und erworbenen Mangelzuständen. Behring Inst Mitt 73:66
Hellgren M, Tengborn L, Abildgaard U (1982) Pregnancy in women with congenital antithrombin III deficiency: experience of treatment with heparin and antithrombin. Gynecol Obstet Invest 14:127
Javelin L (1990) Prophylactic and therapeutic use of antithrombin-III concentrates, in The biology of antithrombins, Sas G., for Library of Congress, Sas G., Editor, 135
Marciniak E, Gockerman JP (1977) Heparin-induced decrease in circulating antithrombin III. Lancet 2:581
Conard J, Horellou MH, van Dresden P, Samama M (1987) Pregnancy and congenital deficiency in antithrombin III or protein C. Thromb Haemost 58:39
Brandt P (1981) Observations during the treatment of antithrombin III deficient women with heparin and antithrombin concentrate during pregnancy, parturition, and abortion. Thromb Res 22:15
Tengborn L, Bengtsson T (1986) Antithrombin III concentrate. Thrombo-prophylaxis during pregnancy in a patient with congenital antithrombin III deficiency. Acta Obstet Gynecol Scand 65:375
Boyer C, Wolf M, Lavergne JM, Haiat A, Declere A, Franco D, Larrieu MJ (1980) Prevention of disseminated intravascular coagulation after LeVeen peritoneovenous shunts by infusions of AT III concentrate, in Proc Sixth Int Congr on Thrombosis of the Mediterranean League against Thromboembolic Disease, Monte Carlo
Büller HR, ten Cate JW (1983) Antithrombin III infusion in patients undergoing peritoneovenous shunt operation: failure in the prevention of disseminated intravascular coagulation. Thromb Haemost 49:128
Schipper HG, Kahlé LH, Jenkins CS, ten Cate JW (1978) Antithrombin Ill-transfusion in disseminated intravascular coagulation. Lancet 1:854
Schipper HG, ten Cate JW (1982) Antithrombin III-transfusion in patients with hepatic cirrhosis. Br J Haematol 52:25
Brandt P, Jespersen J, Gregersen G (1981) Post-partum haemolytic-uraemic syndrome treated with antithrombin III. Nephron 27:15
Büller HR, Weenink AH, Treffers PE, Kahlé LH, Otten HA, ten Cate JW (1980) Severe antithrombin III deficiency in a patient with preeclampsia. Observations on the effect of human AT III concentrate transfusion. Scand J Haematol 25:81
Haak HL, Stolk JC, Gratama JW, van Hulsteyn H, Briet E (1982) Use of antithrombin concentrate in stable diffuse intravascular coagulation. Acta Haematol 68:28
Hellgren M, Hägnevik K, Robbe H, Björk O, Blombäck M, Eklund J (1983) Severe acquired antithrombin III deficiency in relation to hepatic and renal insufficiency and intrauterine fetal death in late pregnancy. Gynecol Obstet Invest 16:107
Jespersen J, Rasmussen NR, Toftgaard C (1982) Observations during the treatment with antithrombin-III concentrate of a case of tampon-related toxic shock syndrome and disseminated intravascular coagulation. Discrepancies between functional and immunologic determinations of antithrombin. Thromb Res 26:457
Laursen B, Mortensen JZ, Frost L, Hansen KB (1981) Disseminated intravascular coagulation in hepatic failure treated with antithrombin III. Thromb Res 22:701
Mosvold J, Abildgaard U, Jenssen H, Andersen R (1982) Low antithrombin III in acute hepatic failure at term. Scand J Haematol 29:48
Weenink GH, Büller HR, ten Cate JW, Smorenberg-Schoorl ME, Schutte MF, Trefferts PE (1980) Severely impaired hemostasis in a preeclampic patient successfully treated with human AT III concentrate and platelet transfusion, in Studies of Antithrombin III and Human Antithrombin III Concentrate Transfusion. Büller HR, ed. Thesis, Wilhelmina Gasthuis, Amsterdam
Hellgren M, Robbe H, Hägnevik K, Faxelius G (1984) Antithrombin as adjuvant in the treatment of acquired antithrombin deficiency during pregnancy and delivery, IV World Congr Int Soc. The Study of Hypertension in Pregnancy, Amsterdam; Abstr 152
Hellgren M, Javelin L, Hägnevik K, Blombäck M, Medén-Britth G (1984) Antithrombin III concentrate as adjuvant in DIC treatment — a pilot study in 9 severely ill patients. Thromb Res 35:459
Potron G, Leroux B, Droulle C, Santepne B, Poynard A (1983) Efficiency of antithrombin treatment in newborn infants with respiratory distress syndrome. Thromb Haemost 50:48
Smith-Erichsen N, Aasen AO, Kongsgaard UE, Bakka A, Bergan A, Bjerkelund CE, Flatmark A, Moen H, Raedder M, Rosseland A, Röise O, Sivertsen S, Skulberg A, Solheim K, Stadaas JA, Sunde S, Vaagenes P (1996) The effect of antithrombin III substitution therapy on components of the plasma protease systems in surgical patients. Clin Int Care 7:291
Albert J (1992) Effect of antithrombin concentrate on haemostatic variables in critically ill patients. Acta Anaesthesiol Scand 36:745
Inthorn D, Storck M, Jochum M (1991) Antithrombin-III in der Therapie des septischen Organversagens. Ergebnisse einer prospektiven Studie. Intensivmed 28:434
Eigl J (1992) Data on file. Pharmacia & Upjohn AB
Kesteven PJ, Ahmed A, Williams BT, Savidge GF (1985) Antithrombin III concentrates in cardiopulmonary bypass. Thromb Haemost 54:89
Grip L, Blombäck M, Egberg N, Olsson Å, Svane B, Velander M (1995) Antithrombin III supplementation to patients undergoing PTCA for unstable angina pectoris. Thromb Haemost 73:6, 1250, Abstr. 1339
Eriksson B (1997) A double virus-inactivated and highly purified antithrombin III concentrate. Suppl to Schock 7:162, Abstr. 651
Horowitz B, Prince AM, Hamman J, Watklevicz C (1994) Viral safety of solvent-detergent-treated blood products. Blood Coagulation and Fibrinolysis 5 (Suppl 3):21
Lindholm A (1994) Epidemiology of viral infections in the Swedish blood-donor population. Blood Coagulation and Fibrinolysis 5 (Suppl 3): 13
Arnberg H, Ryde L, Widlund L, Vietorisz A (1997) Comparison of pharmacokinetics and tolerability of ATenativ® with solvent/detergent treatment, Gesellschaft für Thrombose- und Hämostaseforschung e.V., Wien
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Javelin, L. (1998). ATenativ® — ein hochreines Antithrombinkonzentrat. In: Weilemann, L.S., Schinzel, H. (eds) Antithrombin — Diagnostik und Therapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60305-1_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-60305-1_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-63635-9
Online ISBN: 978-3-642-60305-1
eBook Packages: Springer Book Archive