Hemodynamic and Cardiac Effects of Nisoldipine in Ischemic Left Ventricular Dysfunction
The use of calcium antagonists in patients with left ventricular dysfunction remains a controversial issue, largely because of evidence of reflex neurohormonal activation and of worsening of congestive heart failure symptoms during their administration [1–5]. However, the negative results observed with some calcium antagonists such as nifedipine or diltiazem [4, 5] are balanced by more promising observations with amlodipine and nisoldipine [6, 7]. In these studies, the calcium antagonists were well tolerated and there was evidence of an improvement in left ventricular ejection fraction or diastolic filling as well as in exercise capacity.
KeywordsPlacebo Ischemia Norepinephrine Cardiomyopathy Cardiol
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