Molecular Pathogenesis of B Cell Malignancy: the Role of BCL-6
Human malignancies displaying a mature B cell phenotype include non-Hodgkin lymphoma, (NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM). Analogous to most cancer types, the pathogenesis of these malignancies represents a multistep process involving the progressive and clonal accumulation of multiple genetic lesions affecting proto-oncogenes and tumor suppressor genes. However, several important features distinguish the mechanism and type of genetic alterations associated with NHL, CLL, and MM (Table 1).
KeywordsmUltiple Myeloma Chronic Lymphocytic Leukemia Follicular Lymphoma Germinal Center Chromosomal Translocation
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