Molecular Pathogenesis of B Cell Malignancy: the Role of BCL-6
Human malignancies displaying a mature B cell phenotype include non-Hodgkin lymphoma, (NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM). Analogous to most cancer types, the pathogenesis of these malignancies represents a multistep process involving the progressive and clonal accumulation of multiple genetic lesions affecting proto-oncogenes and tumor suppressor genes. However, several important features distinguish the mechanism and type of genetic alterations associated with NHL, CLL, and MM (Table 1).
KeywordsZinc Lymphoma Tyrosine Leukemia Recombination
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- Albagli O, Dhordain P., Deweindt C. et al. (1995) The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins. Cell Growth & Differ. 6:1193– 1198Google Scholar
- Deweindt C, Albagli O, Bernardin F et al. (1995) The LAZ3/BCL6 oncogene encodes a sequence- specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain. Cell Growth & Differ. 6: 1495 – 503Google Scholar
- Gaidano G, Dalla-Favera R (1997) Molecular biology of Lymphomas. In: Principles and Practice of Oncology, DeVita, VT, Hellman, S., Rosenberg SA (eds) JB Lippincott Co (publ) p. 2131 – 2145Google Scholar