Molecular Pathogenesis of B Cell Malignancy: the Role of BCL-6

  • R. Dalla-Favera
  • A. Migliazza
  • C.-C. Chang
  • H. Niu
  • L. Pasqualucci
  • M. Butler
  • Q. Shen
  • G. Cattoretti
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 246)

Abstract

Human malignancies displaying a mature B cell phenotype include non-Hodgkin lymphoma, (NHL), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM). Analogous to most cancer types, the pathogenesis of these malignancies represents a multistep process involving the progressive and clonal accumulation of multiple genetic lesions affecting proto-oncogenes and tumor suppressor genes. However, several important features distinguish the mechanism and type of genetic alterations associated with NHL, CLL, and MM (Table 1).

Keywords

Zinc Lymphoma Tyrosine Leukemia Recombination 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • R. Dalla-Favera
    • 1
  • A. Migliazza
    • 1
  • C.-C. Chang
    • 1
  • H. Niu
    • 1
  • L. Pasqualucci
    • 1
  • M. Butler
    • 1
  • Q. Shen
    • 1
  • G. Cattoretti
    • 1
  1. 1.Departments of Pathology and Genetics & Development, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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