Abstract
Introduction of ecotropic murine leukemia virus (MuLV) induction loci onto the low-lymphoma, ecotropic MuLV-negative strain, NFS, yielded strains of mice (NFS.V+) that develop a high incidence of hematopoietic neoplasms (1, 2) comprising primarily lymphomas of B cell origin. Histopathologic studies of 645 lymphomas yielded morphologic diagnoses compatible with synonyms provided by the Kiel (3) and REAL (4) classifications of human B lymphomas but applied to the mouse (Table 1). The “Bethesda/Kiel” terminology will be used here. The speculative “LIP/REAL” classification is based on studies suggesting uniting parallels with human neoplasms of these types (e.g., Siminovitch, this volume, for mouse MCL equivalent). MZL, diagnosed only once previously, in NZB (5), were unexpectedly most common in our series, at 36% (Hartley et al., manuscript in preparation)
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Fredrickson TN, Morse HC III, Rowe WP (1984) Spontaneous tumors of NFS mice congenic for ecotropic murine leukemia virus induction loci. JNCI 73: 521 – 524
Fredrickson TN, Hartley JW, Morse HC III, Chattopadhyay SK, Lennert K (1995) Classification of mouse lymphomas. Curr Top Microbiol Immunol 194: 109 – 116
Lennert K, Feller A (1992) Histopathology of non-Hodgkin’s lymphomas, 2d ed. Springer-Verlag, New York
Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, deWolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 5: 1361 – 1392
Yumoto T, Yoshida Y, Yoshida H, Ando K, Matsui K (1980) Prelymphomatous and lymphomatous changes in splenomegaly of New Zealand black mice. Acta Pathol Jpn 30: 171 – 186
Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS, Bradley A (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215 – 221
Purdie CA, Harrison DJ, Peter A, Dobbit L, White S, Howie SEM, Salter DM, Bird CC, Wyllie AH, Hooper ML, Clarke AR (1994) Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene. Oncogene 9: 603 – 609
Kinzler KW, Vogelstein B (1997) Gatekeepers and caretakers. Nature 386: 761 – 762
Ye BH, Cattoretti G, Shen Q, Zhang J, Hawe N, deWaard R, Leung C, Mouri-Shirazi M, Orazi A, Chaganti RSK, Rothman P, Stall AM, Pandolfi P-P, Dalla-Favera R (1997) The BCL-6proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet 16: 161 – 170
Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM (1997) Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 276: 589 – 592
Ye BH, Chaganti S, Chang C-C, Niu H, Corradini P, Chaganti RSK, Dalla-Favera R (1995) Chromosomal translocations cause deregulated BCL6expression by promoter substitution in B cell lymphoma. EMBO J 14: 6209 – 6217
Onizuka T, Moriyama M, Tamochi T, Kuroda T, Kazama A, Kanazawa N, Sato K, Kato T, Ota H, Mori S. BCL-6 gene product, a 92- to 98 kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts. Blood 86:28–37
Rabbitts P, Impey H, Heppell-Parton A, Langford C, Tease C, Lowe N, Bailey D, Ferguson-Smith M, Carter N (1995) Chromosome specific paints from a high resolution flow karyotype of the mouse. Nat Genet 9: 369 – 375
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Morse, H.C. et al. (1999). Novel Aspects of Murine B Cell Lymphomas. In: Melchers, F., Potter, M. (eds) Mechanisms of B Cell Neoplasia 1998. Current Topics in Microbiology and Immunology, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60162-0_31
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DOI: https://doi.org/10.1007/978-3-642-60162-0_31
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